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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18974

FusionGeneSummary for KLF12_KLF12

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF12_KLF12
Fusion gene ID: 18974
HgeneTgene
Gene symbol

KLF12

KLF12

Gene ID

11278

11278

Gene nameKruppel like factor 12Kruppel like factor 12
SynonymsAP-2rep|AP2REP|HSPC122AP-2rep|AP2REP|HSPC122
Cytomap

13q22.1

13q22.1

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2repKrueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep
Modification date2018052320180523
UniProtAcc

Q9Y4X4

Q9Y4X4

Ensembl transtripts involved in fusion geneENST00000377669, ENST00000377666, 
ENST00000472022, 
ENST00000377669, 
ENST00000377666, ENST00000472022, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 10 X 4=360
# samples 711
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLF12 [Title/Abstract] AND KLF12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF12

GO:0000122

negative regulation of transcription by RNA polymerase II

16615998

TgeneKLF12

GO:0000122

negative regulation of transcription by RNA polymerase II

16615998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE073840KLF12chr13

74615582

+KLF12chr13

74615471

-
ChiTaRS3.1AI342559KLF12chr13

74261776

+KLF12chr13

74261709

-
ChiTaRS3.1BE073834KLF12chr13

74615582

+KLF12chr13

74615471

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377669ENST00000377669KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000377669ENST00000377666KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000377669ENST00000472022KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000377666ENST00000377669KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000377666ENST00000377666KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000377666ENST00000472022KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000472022ENST00000377669KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000472022ENST00000377666KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-intronENST00000472022ENST00000472022KLF12chr13

74615582

+KLF12chr13

74615471

-
intron-3UTRENST00000377669ENST00000377669KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000377669ENST00000377666KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000377669ENST00000472022KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-3UTRENST00000377666ENST00000377669KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000377666ENST00000377666KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000377666ENST00000472022KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-3UTRENST00000472022ENST00000377669KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000472022ENST00000377666KLF12chr13

74261776

+KLF12chr13

74261709

-
intron-intronENST00000472022ENST00000472022KLF12chr13

74261776

+KLF12chr13

74261709

-

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FusionProtFeatures for KLF12_KLF12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF12

Q9Y4X4

KLF12

Q9Y4X4

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alphagene promoter. Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alphagene promoter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLF12_KLF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLF12_KLF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLF12_KLF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLF12_KLF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLF12C0036341Schizophrenia1CTD_human
HgeneKLF12C0236969Substance-Related Disorders1CTD_human
TgeneKLF12C0036341Schizophrenia1CTD_human
TgeneKLF12C0236969Substance-Related Disorders1CTD_human