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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18972

FusionGeneSummary for KLF12_CAMK2G

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF12_CAMK2G
Fusion gene ID: 18972
HgeneTgene
Gene symbol

KLF12

CAMK2G

Gene ID

11278

818

Gene nameKruppel like factor 12calcium/calmodulin dependent protein kinase II gamma
SynonymsAP-2rep|AP2REP|HSPC122CAMK|CAMK-II|CAMKG
Cytomap

13q22.1

10q22.2

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2repcalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2018052320180527
UniProtAcc

Q9Y4X4

Q13555

Ensembl transtripts involved in fusion geneENST00000377669, ENST00000377666, 
ENST00000472022, 
ENST00000351293, 
ENST00000322635, ENST00000394762, 
ENST00000423381, ENST00000322680, 
ENST00000305762, ENST00000372765, 
ENST00000472912, ENST00000444854, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 6 X 4=144
# samples 77
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLF12 [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF12

GO:0000122

negative regulation of transcription by RNA polymerase II

16615998

TgeneCAMK2G

GO:0051259

protein complex oligomerization

20668654


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A7WB-01AKLF12chr13

74518118

-CAMK2Gchr10

75577312

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377669ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-5UTRENST00000377669ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377669ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-5UTRENST00000377666ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377666ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-5UTRENST00000472022ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-intronENST00000472022ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-

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FusionProtFeatures for KLF12_CAMK2G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF12

Q9Y4X4

CAMK2G

Q13555

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alphagene promoter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLF12_CAMK2G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLF12_CAMK2G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KLF12EHMT2, APP, CTBP1, THAP1, DYNLT1, DNMT3L, IDO2, TRIM25CAMK2GCALM1, RRAD, SMAD2, SMAD4, USP19, RCHY1, BCL10, MALT1, MYC, CUL3, HSP90AA1, GRIN1, GRIN2B, STMN1, SIVA1, CAMK2A, TIRAP, ECHS1, DACT2, ARHGAP25, NDUFA8, DDX11, PDLIM5, SBDS, CAPZA2, DBN1, IGBP1, TUBG1, IQGAP1, SYNPO, ANLN, THOC2, FLNA, SMAD3, CAMK2D, RBM42, ZNF488


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLF12_CAMK2G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCAMK2GQ13555DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammasmall moleculeapproved

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RelatedDiseases for KLF12_CAMK2G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLF12C0036341Schizophrenia1CTD_human
HgeneKLF12C0236969Substance-Related Disorders1CTD_human