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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18938

FusionGeneSummary for KIN_KIN

check button Fusion gene summary
Fusion gene informationFusion gene name: KIN_KIN
Fusion gene ID: 18938
HgeneTgene
Gene symbol

KIN

KIN

Gene ID

22944

22944

Gene nameKin17 DNA and RNA binding proteinKin17 DNA and RNA binding protein
SynonymsBTCD|KIN17|Rts2BTCD|KIN17|Rts2
Cytomap

10p14

10p14

Type of geneprotein-codingprotein-coding
DescriptionDNA/RNA-binding protein KIN17KIN, antigenic determinant of recA protein homologbinding to curved DNADNA/RNA-binding protein KIN17KIN, antigenic determinant of recA protein homologbinding to curved DNA
Modification date2018052320180523
UniProtAcc

O60870

O60870

Ensembl transtripts involved in fusion geneENST00000379562, ENST00000535925, 
ENST00000463666, ENST00000543003, 
ENST00000379562, ENST00000535925, 
ENST00000463666, ENST00000543003, 
Fusion gene scores* DoF score2 X 4 X 2=161 X 3 X 1=3
# samples 54
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/3*10)=3.73696559416621
Context

PubMed: KIN [Title/Abstract] AND KIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIN

GO:0006260

DNA replication

12359749

TgeneKIN

GO:0006260

DNA replication

12359749


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB243501KINchr10

7797862

+KINchr10

7801909

-
ChiTaRS3.1BE011287KINchr10

7822668

-KINchr10

7827515

-
ChiTaRS3.1CV376788KINchr10

7827515

+KINchr10

7822668

+
ChiTaRS3.1CV376786KINchr10

7822668

-KINchr10

7827515

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000379562ENST00000379562KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000379562ENST00000535925KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000379562ENST00000463666KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000379562ENST00000543003KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000535925ENST00000379562KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000535925ENST00000535925KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000535925ENST00000463666KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000535925ENST00000543003KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000463666ENST00000379562KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000463666ENST00000535925KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000463666ENST00000463666KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000463666ENST00000543003KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000543003ENST00000379562KINchr10

7797862

+KINchr10

7801909

-
intron-3CDSENST00000543003ENST00000535925KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000543003ENST00000463666KINchr10

7797862

+KINchr10

7801909

-
intron-5UTRENST00000543003ENST00000543003KINchr10

7797862

+KINchr10

7801909

-
intron-intronENST00000379562ENST00000379562KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000379562ENST00000535925KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000379562ENST00000463666KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000379562ENST00000543003KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000535925ENST00000379562KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000535925ENST00000535925KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000535925ENST00000463666KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000535925ENST00000543003KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000463666ENST00000379562KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000463666ENST00000535925KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000463666ENST00000463666KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000463666ENST00000543003KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000543003ENST00000379562KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000543003ENST00000535925KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000543003ENST00000463666KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000543003ENST00000543003KINchr10

7822668

-KINchr10

7827515

-
intron-intronENST00000379562ENST00000379562KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000379562ENST00000535925KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000379562ENST00000463666KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000379562ENST00000543003KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000535925ENST00000379562KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000535925ENST00000535925KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000535925ENST00000463666KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000535925ENST00000543003KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000463666ENST00000379562KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000463666ENST00000535925KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000463666ENST00000463666KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000463666ENST00000543003KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000543003ENST00000379562KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000543003ENST00000535925KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000543003ENST00000463666KINchr10

7827515

+KINchr10

7822668

+
intron-intronENST00000543003ENST00000543003KINchr10

7827515

+KINchr10

7822668

+

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FusionProtFeatures for KIN_KIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIN

O60870

KIN

O60870

Involved in DNA replication and the cellular response toDNA damage. May participate in DNA replication factories andcreate a bridge between DNA replication and repair mediated byhigh molecular weight complexes. May play a role in illegitimaterecombination and regulation of gene expression. May participatein mRNA processing. Binds, in vitro, to double-stranded DNA. Alsoshown to bind preferentially to curved DNA in vitro and in vivo(By similarity). Binds via its C-terminal domain to RNA in vitro.{ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372,ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299,ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485,ECO:0000269|PubMed:17045609}. Involved in DNA replication and the cellular response toDNA damage. May participate in DNA replication factories andcreate a bridge between DNA replication and repair mediated byhigh molecular weight complexes. May play a role in illegitimaterecombination and regulation of gene expression. May participatein mRNA processing. Binds, in vitro, to double-stranded DNA. Alsoshown to bind preferentially to curved DNA in vitro and in vivo(By similarity). Binds via its C-terminal domain to RNA in vitro.{ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372,ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299,ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485,ECO:0000269|PubMed:17045609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIN_KIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIN_KIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIN_KIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIN_KIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource