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Fusion gene ID: 18937 |
FusionGeneSummary for KIN_ITIH5 |
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Fusion gene information | Fusion gene name: KIN_ITIH5 | Fusion gene ID: 18937 | Hgene | Tgene | Gene symbol | KIN | ITIH5 | Gene ID | 22944 | 80760 |
Gene name | Kin17 DNA and RNA binding protein | inter-alpha-trypsin inhibitor heavy chain family member 5 | |
Synonyms | BTCD|KIN17|Rts2 | ITI-HC5|PP14776 | |
Cytomap | 10p14 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA/RNA-binding protein KIN17KIN, antigenic determinant of recA protein homologbinding to curved DNA | inter-alpha-trypsin inhibitor heavy chain H5ITI heavy chain H5inter-alpha (globulin) inhibitor H5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O60870 | Q86UX2 | |
Ensembl transtripts involved in fusion gene | ENST00000379562, ENST00000535925, ENST00000463666, ENST00000543003, | ENST00000256861, ENST00000397146, ENST00000298441, ENST00000446830, ENST00000434980, ENST00000397145, | |
Fusion gene scores | * DoF score | 2 X 4 X 2=16 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KIN [Title/Abstract] AND ITIH5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KIN | GO:0006260 | DNA replication | 12359749 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E2-A1LK-01A | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000379562 | ENST00000256861 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000379562 | ENST00000397146 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000379562 | ENST00000298441 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000379562 | ENST00000446830 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000379562 | ENST00000434980 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000379562 | ENST00000397145 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
Frame-shift | ENST00000535925 | ENST00000256861 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000535925 | ENST00000397146 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000535925 | ENST00000298441 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000535925 | ENST00000446830 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000535925 | ENST00000434980 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
5CDS-intron | ENST00000535925 | ENST00000397145 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-3CDS | ENST00000463666 | ENST00000256861 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000463666 | ENST00000397146 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000463666 | ENST00000298441 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000463666 | ENST00000446830 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000463666 | ENST00000434980 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000463666 | ENST00000397145 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-3CDS | ENST00000543003 | ENST00000256861 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000543003 | ENST00000397146 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000543003 | ENST00000298441 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000543003 | ENST00000446830 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000543003 | ENST00000434980 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
intron-intron | ENST00000543003 | ENST00000397145 | KIN | chr10 | 7825044 | - | ITIH5 | chr10 | 7611747 | - |
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FusionProtFeatures for KIN_ITIH5 |
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Hgene | Tgene |
KIN | ITIH5 |
Involved in DNA replication and the cellular response toDNA damage. May participate in DNA replication factories andcreate a bridge between DNA replication and repair mediated byhigh molecular weight complexes. May play a role in illegitimaterecombination and regulation of gene expression. May participatein mRNA processing. Binds, in vitro, to double-stranded DNA. Alsoshown to bind preferentially to curved DNA in vitro and in vivo(By similarity). Binds via its C-terminal domain to RNA in vitro.{ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372,ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299,ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485,ECO:0000269|PubMed:17045609}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIN_ITIH5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIN_ITIH5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KIN | RPA2, RPA1, METTL22, PCNA, HECW2, DNAJC17, EIF2D, PABPC1, RECQL5 | ITIH5 | BRCA1, BAG4, CHEK2, ESR2, HMMR, NOTCH2, PPM1D, RAD51, RB1CC1, XRCC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIN_ITIH5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIN_ITIH5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |