FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18927

FusionGeneSummary for KIF9_GYG1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF9_GYG1
Fusion gene ID: 18927
HgeneTgene
Gene symbol

KIF9

GYG1

Gene ID

64147

2992

Gene namekinesin family member 9glycogenin 1
Synonyms-GSD15|GYG
Cytomap

3p21.31

3q24

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF9kinesin protein 9glycogenin-1GN-1glycogenin glucosyltransferase
Modification date2018052320180522
UniProtAcc

Q9HAQ2

P46976

Ensembl transtripts involved in fusion geneENST00000335044, ENST00000265529, 
ENST00000444589, ENST00000452770, 
ENST00000352910, ENST00000487440, 
ENST00000425853, ENST00000432493, 
ENST00000425452, 		ENST00000345003, 
ENST00000296048, ENST00000483267, 
ENST00000484197, ENST00000479119, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 4 X 3=60
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF9 [Title/Abstract] AND GYG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-B5-A3S1-01AKIF9chr3

47323985

-GYG1chr3

148741840

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000335044ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000335044ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000335044ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000335044ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000335044ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000265529ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000265529ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000265529ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000265529ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000265529ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000444589ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000444589ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000444589ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000444589ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000444589ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000452770ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000452770ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000452770ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000452770ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000452770ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000352910ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000352910ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000352910ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000352910ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000352910ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000487440ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000487440ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000487440ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000487440ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000487440ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425853ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425853ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425853ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-intronENST00000425853ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-intronENST00000425853ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000432493ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000432493ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-3CDSENST00000432493ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000432493ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
5UTR-intronENST00000432493ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425452ENST00000345003KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425452ENST00000296048KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-3CDSENST00000425452ENST00000483267KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-intronENST00000425452ENST00000484197KIF9chr3

47323985

-GYG1chr3

148741840

+
intron-intronENST00000425452ENST00000479119KIF9chr3

47323985

-GYG1chr3

148741840

+

Top

FusionProtFeatures for KIF9_GYG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF9

Q9HAQ2

GYG1

P46976

Self-glucosylates, via an inter-subunit mechanism, toform an oligosaccharide primer that serves as substrate forglycogen synthase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIF9_GYG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIF9_GYG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF9PRMT6, TRIM37, TRIM27, JAKMIP2, IKZF1, ROPN1, CARD9, EFHC2, LZTS2, SSX2IP, KRTAP10-9, KRTAP10-3, ZBTB8A, FAM188AGYG1GYS1, POM121, TRIM7, GYG2, PRKAA2, PRKAB2, CD6, CMSS1, PPP1R3B, PPP1R3C, PPP1CA, STBD1, ZFP41, ESD, GGT1, GOT2, PGM5, XPO1, GBE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIF9_GYG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIF9_GYG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGYG1C0003811Cardiac Arrhythmia1CTD_human
TgeneGYG1C0017919Glycogen Storage Disease1CTD_human
TgeneGYG1C0151744Myocardial Ischemia1CTD_human
TgeneGYG1C0151786Muscle Weakness1CTD_human;HPO
TgeneGYG1C3150754GLYCOGEN STORAGE DISEASE XV1CTD_human;ORPHANET;UNIPROT
TgeneGYG1C4015452POLYGLUCOSAN BODY MYOPATHY 21ORPHANET;UNIPROT