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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18917

FusionGeneSummary for KIF5B_RET

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF5B_RET
Fusion gene ID: 18917
HgeneTgene
Gene symbol

KIF5B

RET

Gene ID

3799

5979

Gene namekinesin family member 5Bret proto-oncogene
SynonymsHEL-S-61|KINH|KNS|KNS1|UKHCCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

10p11.22

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionkinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chainproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2018052320180527
UniProtAcc

P33176

P07949

Ensembl transtripts involved in fusion geneENST00000302418, ENST00000493889, 
ENST00000355710, ENST00000340058, 
Fusion gene scores* DoF score7 X 7 X 6=29418 X 10 X 7=1260
# samples 1965
** MAII scorelog2(19/294*10)=-0.629816736505416
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(65/1260*10)=-0.954912110471462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF5B [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing (pmid: 22194472)
Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF5B

GO:0042391

regulation of membrane potential

19675065

HgeneKIF5B

GO:0043268

positive regulation of potassium ion transport

19675065

HgeneKIF5B

GO:0047496

vesicle transport along microtubule

28426968

HgeneKIF5B

GO:1903078

positive regulation of protein localization to plasma membrane

19675065

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1HW088349KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS3.1HW088351KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS3.1HW088350KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS3.1HW088352KIF5Bchr10

32306071

-RETchr10

43607546

+
ChiTaRS3.1AB795254KIF5Bchr10

32307243

-RETchr10

43612030

+
ChiTaRS3.1AB795255KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS3.1AB795252KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS3.1AB795253KIF5Bchr10

32307243

-RETchr10

43612030

+
ChiTaRS3.1AB795250KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS3.1AB795249KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS3.1AB795256KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS3.1AB795251KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS3.1AB795257KIF5Bchr10

32306071

-RETchr10

43609927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000302418ENST00000355710KIF5Bchr10

32317355

-RETchr10

43612030

+
In-frameENST00000302418ENST00000340058KIF5Bchr10

32317355

-RETchr10

43612030

+
intron-3CDSENST00000493889ENST00000355710KIF5Bchr10

32317355

-RETchr10

43612030

+
intron-3CDSENST00000493889ENST00000340058KIF5Bchr10

32317355

-RETchr10

43612030

+
In-frameENST00000302418ENST00000355710KIF5Bchr10

32306979

-RETchr10

43612030

+
In-frameENST00000302418ENST00000340058KIF5Bchr10

32306979

-RETchr10

43612030

+
5UTR-3CDSENST00000493889ENST00000355710KIF5Bchr10

32306979

-RETchr10

43612030

+
5UTR-3CDSENST00000493889ENST00000340058KIF5Bchr10

32306979

-RETchr10

43612030

+
In-frameENST00000302418ENST00000355710KIF5Bchr10

32311775

-RETchr10

43612032

+
In-frameENST00000302418ENST00000340058KIF5Bchr10

32311775

-RETchr10

43612032

+
intron-3CDSENST00000493889ENST00000355710KIF5Bchr10

32311775

-RETchr10

43612032

+
intron-3CDSENST00000493889ENST00000340058KIF5Bchr10

32311775

-RETchr10

43612032

+
Frame-shiftENST00000302418ENST00000355710KIF5Bchr10

32306071

-RETchr10

43607546

+
Frame-shiftENST00000302418ENST00000340058KIF5Bchr10

32306071

-RETchr10

43607546

+
intron-3CDSENST00000493889ENST00000355710KIF5Bchr10

32306071

-RETchr10

43607546

+
intron-3CDSENST00000493889ENST00000340058KIF5Bchr10

32306071

-RETchr10

43607546

+
In-frameENST00000302418ENST00000355710KIF5Bchr10

32307243

-RETchr10

43612030

+
In-frameENST00000302418ENST00000340058KIF5Bchr10

32307243

-RETchr10

43612030

+
intron-3CDSENST00000493889ENST00000355710KIF5Bchr10

32307243

-RETchr10

43612030

+
intron-3CDSENST00000493889ENST00000340058KIF5Bchr10

32307243

-RETchr10

43612030

+
Frame-shiftENST00000302418ENST00000355710KIF5Bchr10

32306071

-RETchr10

43609927

+
Frame-shiftENST00000302418ENST00000340058KIF5Bchr10

32306071

-RETchr10

43609927

+
intron-3CDSENST00000493889ENST00000355710KIF5Bchr10

32306071

-RETchr10

43609927

+
intron-3CDSENST00000493889ENST00000340058KIF5Bchr10

32306071

-RETchr10

43609927

+

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FusionProtFeatures for KIF5B_RET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF5B

P33176

RET

P07949

Microtubule-dependent motor required for normaldistribution of mitochondria and lysosomes. Can induce formationof neurite-like membrane protrusions in non-neuronal cells in aZFYVE27-dependent manner (By similarity). Regulates centrosome andnuclear positioning during mitotic entry. During the G2 phase ofthe cell cycle in a BICD2-dependent manner, antagonizes dyneinfunction and drives the separation of nuclei and centrosomes(PubMed:20386726). {ECO:0000250|UniProtKB:Q61768,ECO:0000269|PubMed:20386726}. Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-23268_3258481626DomainKinesin motor
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-22268_3258131626DomainKinesin motor
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-16268_3256381626DomainKinesin motor
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-15268_3255751626DomainKinesin motor
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-232685_928481626Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-222685_928131626Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-162685_926381626Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-152685_925751626Nucleotide bindingNote=ATP
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-2326329_9148481626Coiled coil.
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-2226329_9148131626Coiled coil.
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-1626329_9146381626Coiled coil.
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-1526329_9145751626Coiled coil.
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-2326915_9638481626RegionNote=Globular
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-2226915_9638131626RegionNote=Globular
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-1626915_9636381626RegionNote=Globular
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-1526915_9635751626RegionNote=Globular
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr10:32306979chr10:43612030ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr10:32306979chr10:43612030ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr10:32307243chr10:43612030ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr10:32307243chr10:43612030ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr10:32311775chr10:43612032ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr10:32311775chr10:43612032ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr10:32317355chr10:43612030ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr10:32317355chr10:43612030ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr10:32306979chr10:43612030ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr10:32306979chr10:43612030ENST00000355710+1020636_6577121115TransmembraneHelical
TgeneRETchr10:32307243chr10:43612030ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr10:32307243chr10:43612030ENST00000355710+1020636_6577121115TransmembraneHelical
TgeneRETchr10:32311775chr10:43612032ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr10:32311775chr10:43612032ENST00000355710+1020636_6577121115TransmembraneHelical
TgeneRETchr10:32317355chr10:43612030ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr10:32317355chr10:43612030ENST00000355710+1020636_6577121115TransmembraneHelical


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FusionGeneSequence for KIF5B_RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000355710_chr10_43612030_+_403aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE

>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000340058_chr10_43612030_+_361aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000355710_chr10_43612030_+_403aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000340058_chr10_43612030_+_361aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000355710_chr10_43612032_+_403aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGE

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000340058_chr10_43612032_+_361aa
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD
FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR
LMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000355710_chr10_43612030_+_1209nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAG
AGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCA

>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000340058_chr10_43612030_+_1083nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTC

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000355710_chr10_43612030_+_1209nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAG
AGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCA

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000340058_chr10_43612030_+_1083nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTC

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000355710_chr10_43612032_+_1209nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAG
AGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCA

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000340058_chr10_43612032_+_1083nt
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000355710_chr10_43612030_+_5474nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGT
CAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTG
TATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCA
CAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTG
GCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACAC
CGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACC
ACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCG
CCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAG
AATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTC
AGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCC
TAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCC
CGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCC
CAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCA
GTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCT
AGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTA
TAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGAC
CATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGG
GAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGAC
TTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTG
TGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACA
CGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTT
CAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATT
GCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCC
TTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAA
GTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACC

>In-frame_KIF5B_ENST00000302418_chr10_32317355_-_RET_ENST00000340058_chr10_43612030_+_4016nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAA
TTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTG
AACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTT
TTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCA
GGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAA
ATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGG
GCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCA
GGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGAC
GGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGT

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000355710_chr10_43612030_+_6293nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGCAGCCTGAGGGAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGA
AGTCAGAAGTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGG
AGTTAGCAGCATGTCAGCTTCGTATCTCTCAACATGAAGCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAA
GACAGTTGGAGGAATCTGTCGATGCCCTCAGTGAAGAACTAGTCCAGCTTCGAGCACAAGAGAAAGTCCATGAAATGGAAAAGGAGCACT
TAAATAAGGTTCAGACTGCAAATGAAGTTAAGCAAGCTGTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTA
GTTTGAGAGATGAAGTAGAAGCAAAAGCAAAACTTATTACTGATCTTCAAGACCAAAACCAGAAAATGATGTTAGAGCAGGAACGTCTAA
GAGTAGAACATGAGAAGTTGAAAGCCACAGATCAGGAAAAGAGCAGAAAACTACATGAACTTACGGTTATGCAAGATAGACGAGAACAAG
CAAGACAAGACTTGAAGGGTTTGGAAGAGACAGTGGCAAAAGAACTTCAGACTTTACACAACCTGCGCAAACTCTTTGTTCAGGACCTGG
CTACAAGAGTTAAAAAGAGTGCTGAGATTGATTCTGATGACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATA
ATCTTGAACAGCTCACTAAAGTGCACAAACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAG
AAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAG
AGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATG
GGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAG
TGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCA
TCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGG
TAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTC
GGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGT
GGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGA
GGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCA
GCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACG
GCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCT
ATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAA
ATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTA
ATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGT
TCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGAC
ATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCA
TCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTC
TAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTC
CTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGG
CCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAA
GATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACA
TTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTG
TTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAG
GCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGAC
AGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTT
TGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTA
GATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGC
AGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGC
TCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGT
GGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCT
TATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACT
TTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAA
GTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACC
AATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTA
AATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGT

>In-frame_KIF5B_ENST00000302418_chr10_32306979_-_RET_ENST00000340058_chr10_43612030_+_4835nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGCAGCCTGAGGGAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGA
AGTCAGAAGTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGG
AGTTAGCAGCATGTCAGCTTCGTATCTCTCAACATGAAGCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAA
GACAGTTGGAGGAATCTGTCGATGCCCTCAGTGAAGAACTAGTCCAGCTTCGAGCACAAGAGAAAGTCCATGAAATGGAAAAGGAGCACT
TAAATAAGGTTCAGACTGCAAATGAAGTTAAGCAAGCTGTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTA
GTTTGAGAGATGAAGTAGAAGCAAAAGCAAAACTTATTACTGATCTTCAAGACCAAAACCAGAAAATGATGTTAGAGCAGGAACGTCTAA
GAGTAGAACATGAGAAGTTGAAAGCCACAGATCAGGAAAAGAGCAGAAAACTACATGAACTTACGGTTATGCAAGATAGACGAGAACAAG
CAAGACAAGACTTGAAGGGTTTGGAAGAGACAGTGGCAAAAGAACTTCAGACTTTACACAACCTGCGCAAACTCTTTGTTCAGGACCTGG
CTACAAGAGTTAAAAAGAGTGCTGAGATTGATTCTGATGACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATA
ATCTTGAACAGCTCACTAAAGTGCACAAACAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAG
AAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAG
AGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATG
GGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAG
TGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCA
TCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGG
TAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTC
GGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGT
GGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGA
GGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCA
GCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACG
GCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCT
ATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTT
TCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCA
ACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCG
GAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATA
AATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGAC
CCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGT
CCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCAC
CTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACA

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000355710_chr10_43612032_+_5663nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGCAGCCTGAGGGAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGA
AGTCAGAAGTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGG
AGTTAGCAGCATGTCAGCTTCGTATCTCTCAAGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAG
AAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAG
AGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATG
GGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAG
TGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCA
TCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGG
TAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTC
GGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGT
GGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGA
GGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCA
GCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACG
GCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCT
ATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAA
ATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTA
ATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGT
TCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGAC
ATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCA
TCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTC
TAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTC
CTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGG
CCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAA
GATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACA
TTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTG
TTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAG
GCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGAC
AGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTT
TGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTA
GATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGC
AGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGC
TCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGT
GGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCT
TATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACT
TTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAA
GTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACC
AATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTA
AATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGT

>In-frame_KIF5B_ENST00000302418_chr10_32311775_-_RET_ENST00000340058_chr10_43612032_+_4205nt
CGCCCTGTCGCCCAACGGCGGCCTCAGGAGTGATCGGGCAGCAGTCGGCCGGCCAGCGGACGGCAGAGCGGGCGGACGGGTAGGCCCGGC
CTGCTCTTCGCGAGGAGGAAGAAGGTGGCCACTCTCCCGGTCCCCAGAACCTCCCCAGCCCCCGCAGTCCGCCCAGACCGTAAAGGGGGA
CGCTGAGGAGCCGCGGACGCTCTCCCCGGTGCCGCCGCCGCTGCCGCCGCCATGGCTGCCATGATGGATCGGAAGTGAGCATTAGGGTTA
ACGGCTGCCGGCGCCGGCTCTTCAAGTCCCGGCTCCCCGGCCGCCTCCACCCGGGGAAGCGCAGCGCGGCGCAGCTGACTGCTGCCTCTC
ACGGCCCTCGCGACCACAAGCCCTCAGGTCCGGCGCGTTCCCTGCAAGACTGAGCGGCGGGGAGTGGCTCCCGGCCGCCGGCCCCGGCTG
CGAGAAAGATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAGTCTGAAGTGAACCGCGGCGACA
AGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTGATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTC
AAGAGCAAGTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACAATATTTGCATATGGACAAACAT
CCTCTGGGAAGACACACACAATGGAGGGTAAACTTCATGATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATT
ATATTTACTCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGATAAGATAAGGGACCTGTTAGATG
TTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAACCGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATG
AAGTTATGGATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACATAGCTCTAGGAGTCACAGTATAT
TTCTTATTAATGTCAAACAAGAGAACACACAAACGGAACAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGG
TTAGTAAAACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCTCTTGGAAATGTTATTTCTGCTT
TGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGTAAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTA
TTGTAATTTGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAAAGGGCCAAAACAATTAAGAACA
CAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGGAAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTA
TTCAGTGGCTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTTGACAAAGAGAAAGCCAACTTGG
AAGCTTTCACAGTGGATAAAGATATTACTCTTACCAATGATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAA
GAAGAAAGTGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAACCAGCAAAGTCAACTGGTAGAGA
AACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTGGCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTC
AAGCAGAAAATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTCAATTATGATCAGAAGTCTCAGG
AAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGTGATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTC
AGAAACTTAAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAAGACCTTGCAGAAATAGGAATTG
CTGTGGGAAATAATGATGTAAAGCAGCCTGAGGGAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGA
AGTCAGAAGTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGG
AGTTAGCAGCATGTCAGCTTCGTATCTCTCAAGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAG
AAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAG
AGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATG
GGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAG
TGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCA
TCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGG
TAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTC
GGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGT
GGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGA
GGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCA
GCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACG
GCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCT
ATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTT
TCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCA
ACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCG
GAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATA
AATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGAC
CCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGT
CCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCAC
CTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACA


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FusionGenePPI for KIF5B_RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF5BYWHAG, YWHAB, YWHAQ, YWHAZ, VDAC1, NME2, SFN, DTNB, SNAP23, SNAP25, KLC1, KLC2, KIF5C, YWHAH, USPL1, MARK2, MEPCE, FYCO1, RAPGEF2, APC, SPG20, CDC5L, GSK3B, NDRG1, SIRT7, RANBP2, KIAA0368, KLC4, ZBTB8B, KDM1A, MCCC1, EXOC7, DHX9, TWF1, SRP68, RNF168, YWHAE, CFTR, ACACA, CAST, COPE, COPS5, AKAP2, DIAPH1, ELP2, EPB41L1, NUP50, RNF20, PSMA2, PSMA4, PSMA5, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSME1, PTPN23, RABGAP1, SMEK2, TRIM25, STAU1, AURKB, HUWE1, PRKAR2B, VPS52, TAX1BP1, ZBTB8A, CUL7, EZH2, ABCE1, TRAK2, CCDC101, SYNE4, DTNBP1, NUP43, KPTN, AZIN1, TRIP6, CHRNA9, RPS6KB2, KIF1A, LSM2, NTRK1, MED4, L1TD1, KLC3, NHS, POU1F1, TUBA1A, OGT, SQSTM1, XPR1, NCOR1, TRAK1, KIDINS220, SLC38A10, FOXQ1, CDH1, MYCL, COG6, EXOC1, MAP7D2, HOMER1, DLST, SOD1, BRCA1RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF5B_RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for KIF5B_RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF5BC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneKIF5BC0011849Diabetes Mellitus1CTD_human
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
TgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
TgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
TgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET