FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18897

FusionGeneSummary for KIF3B_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3B_SCFD2
Fusion gene ID: 18897
HgeneTgene
Gene symbol

KIF3B

SCFD2

Gene ID

9371

152579

Gene namekinesin family member 3Bsec1 family domain containing 2
SynonymsFLA8|HH0048|KLP-11STXBP1L1
Cytomap

20q11.21

4q12

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3Bmicrotubule plus end-directed kinesin motor 3Bsec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018052320180519
UniProtAcc

O15066

Q8WU76

Ensembl transtripts involved in fusion geneENST00000375712, ENST00000418717, 
ENST00000401642, ENST00000388940, 
Fusion gene scores* DoF score8 X 6 X 6=28810 X 8 X 10=800
# samples 811
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF3B [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2Z-01AKIF3Bchr20

30898984

+SCFD2chr4

53787037

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000375712ENST00000401642KIF3Bchr20

30898984

+SCFD2chr4

53787037

-
Frame-shiftENST00000375712ENST00000388940KIF3Bchr20

30898984

+SCFD2chr4

53787037

-
Frame-shiftENST00000418717ENST00000401642KIF3Bchr20

30898984

+SCFD2chr4

53787037

-
Frame-shiftENST00000418717ENST00000388940KIF3Bchr20

30898984

+SCFD2chr4

53787037

-

Top

FusionProtFeatures for KIF3B_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3B

O15066

SCFD2

Q8WU76

Involved in tethering the chromosomes to the spindlepole and in chromosome movement. Microtubule-based anterogradetranslocator for membranous organelles. Plus end-directedmicrotubule sliding activity in vitro (By similarity).{ECO:0000250}. May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIF3B_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIF3B_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF3BRAB4A, RAB5A, MAP3K11, RAD21, NEDD4L, VHL, KIF3A, APP, LMO4, LMO2, MOV10, NXF1, NTRK1, RANBP2, KIFAP3, KIAA1279, RGS20, AKAP12, STK4, DYRK2, SAV1, KIF3C, PSMC5, STK3, SLC9A3R2SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIF3B_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIF3B_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource