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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 18890

FusionGeneSummary for KIF3A_PDLIM4

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3A_PDLIM4
Fusion gene ID: 18890
HgeneTgene
Gene symbol

KIF3A

PDLIM4

Gene ID

11127

8572

Gene namekinesin family member 3APDZ and LIM domain 4
SynonymsFLA10|KLP-20RIL
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3Akinesin family protein 3Amicrotubule plus end-directed kinesin motor 3APDZ and LIM domain protein 4LIM domain proteinLIM protein RILenigma homologreversion-induced LIM protein
Modification date2018052720180519
UniProtAcc

Q9Y496

P50479

Ensembl transtripts involved in fusion geneENST00000378746, ENST00000378735, 
ENST00000403231, ENST00000487055, 
ENST00000253754, ENST00000379018, 
ENST00000484620, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 1 X 3=9
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF3A [Title/Abstract] AND PDLIM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDLIM4

GO:0031532

actin cytoskeleton reorganization

21636573


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-HU-8238-01AKIF3Achr5

132073106

-PDLIM4chr5

131598302

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000378746ENST00000253754KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
In-frameENST00000378746ENST00000379018KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
5CDS-intronENST00000378746ENST00000484620KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
In-frameENST00000378735ENST00000253754KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
In-frameENST00000378735ENST00000379018KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
5CDS-intronENST00000378735ENST00000484620KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
In-frameENST00000403231ENST00000253754KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
In-frameENST00000403231ENST00000379018KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
5CDS-intronENST00000403231ENST00000484620KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
intron-3CDSENST00000487055ENST00000253754KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
intron-3CDSENST00000487055ENST00000379018KIF3Achr5

132073106

-PDLIM4chr5

131598302

+
intron-intronENST00000487055ENST00000484620KIF3Achr5

132073106

-PDLIM4chr5

131598302

+

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FusionProtFeatures for KIF3A_PDLIM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3A

Q9Y496

PDLIM4

P50479

Microtubule-based anterograde translocator formembranous organelles. Plus end-directed microtubule slidingactivity in vitro. Plays a role in primary cilia formation. Playsa role in centriole cohesion and subdistal appendage organizationand function. Regulates the formation of the subdistal appendagevia recruitement of DCTN1 to the centriole. Also required forciliary basal feet formation and microtubule anchoring to mothercentriole. {ECO:0000250|UniProtKB:P28741}. Isoform 1: Suppresses SRC activation by recognizing andbinding to active SRC and facilitating PTPN13-mediateddephosphorylation of SRC 'Tyr-419' leading to its inactivation.Inactivated SRC dissociates from this protein allowing theinitiation of a new SRC inactivation cycle (PubMed:19307596).Involved in reorganization of the actin cytoskeleton(PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin(filamentous actin), and promotes formation of actin stressfibers. Involved in regulation of the synaptic AMPA receptortransport in dendritic spines of hippocampal pyramidal neuronsdirecting the receptors toward an insertion at the postsynapticmembrane. Links endosomal surface-internalized GRIA1-containingAMPA receptors to the alpha-actinin/actin cytoskeleton. IncreasesAMPA receptor-mediated excitatory postsynaptic currents in neurons(By similarity). {ECO:0000250|UniProtKB:P36202,ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}. Isoform 2: Involved in reorganization of the actincytoskeleton and in regulation of cell migration. In response tooxidative stress, binds to NQO1, which stabilizes it and protectsit from ubiquitin-independent degradation by the core 20Sproteasome. Stabilized protein is able to heterodimerize withisoform 1 changing the subcellular location of it fromcytoskeleton and nuclei to cytosol, leading to loss of isoforms 1ability to induce formation of actin stress fibers. Counteractsthe effects produced by isoform 1 on organization of actincytoskeleton and cell motility to fine-tune actin cytoskeletonrearrangement and to attenuate cell migration.{ECO:0000269|PubMed:21636573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDLIM4chr5:132073106chr5:131598302ENST00000253754+07253_31231331DomainLIM zinc-binding
TgenePDLIM4chr5:132073106chr5:131598302ENST00000379018+06253_31231247DomainLIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Achr5:132073106chr5:131598302ENST00000378746-117355_5902700Coiled coilOntology_term=ECO:0000255
HgeneKIF3Achr5:132073106chr5:131598302ENST00000378746-11714_3452700DomainKinesin motor
HgeneKIF3Achr5:132073106chr5:131598302ENST00000378746-117100_1072700Nucleotide bindingATP
HgeneKIF3Achr5:132073106chr5:131598302ENST00000378746-117697_6992700RegionNote=Globular
TgenePDLIM4chr5:132073106chr5:131598302ENST00000253754+071_8431331DomainPDZ
TgenePDLIM4chr5:132073106chr5:131598302ENST00000379018+061_8431247DomainPDZ


Top

FusionGeneSequence for KIF3A_PDLIM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_302aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG
SFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDER

>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_218aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_302aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG
SFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDER

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_218aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_302aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG
SFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDER

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_218aa
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_906nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCC
AGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCA
CGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGG
CTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTC

>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_654nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCT

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_906nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCC
AGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCA
CGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGG
CTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTC

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_654nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCT

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_906nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCC
AGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCA
CGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGG
CTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTC

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_654nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_2350nt
GCGCAGGCGTAATTCAAGGGCCGAGAGAGCCTGAGACTGGGCTTGGGGCGGGGCGAGCTCGGAATGCGGCTGCGCACTGGGCGCTCTCGC
CCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCGCACCCGGTGTCGCTGGGCTGCACC
CCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGA
GACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTC
ACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCT
GAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCA
TATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCA
CCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAG
CCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGG
CCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCCAGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACG
CGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTG
AACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTAC
GACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGG
CCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGCTCCTCTGCTCCACCTTGAACCTGTCACCTGGCCTGCCACCCTCCTGCGCAG
GCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGGTGCCAGGCATGTCCTAGGCTCTGGGTGCAGTAGTGAGCAGGACGGGTACCA
TGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAGACCTGAATCACAACGGGCCAGCTCTAGTAATACGAAGGTGAGGTCTGGGAT
GCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTGGGGTCAGGGAAAGTCTTAGCTGAGAACTAAGAGATGAGGGAGGCACAAACT
CTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGGCGAGAAAGGCCTCTGTGGCCGTCATCGGCACTAGCGGGTTGGGGGTGGTGG
TGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGAGAGGGTGATTGAGTGTGGAGATCACCGGGGCCGCCGCGGGCCGTCTGCACT
TCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTTCTTCCACCCACGAGCACTTTATTCTCCTCCGAGACCCCCTTTTCTTCCCCT
TCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAGACAGAGACCAGAAGGAAGGTTTAGAAAGAAAAGAACACTTGCCCAGGGCAG
CTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAATTCCACCCCTCCTCGAAGTCCCGGCTTCCACCCCTCTCCTCAGAGTCCCGG
CGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGCCCCGGCTGCACACATCGTCTGTGAATTGTGGCTGTTCACTCCCGAGGATGT
GTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTTACTTGCTCGGGAGAAGAAACTGACTCGTTTTATTTAGTGCCTATTTAGCGA
GCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGTGCTATCGCAAATCACAAAAAAACTGTTATCAATTCACATTCATCATCAGCA
CGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATATTATGTTTCTTTTTTCATTTTTGCCAGTCTGTTAAGTAAAATGTCATATGCG

>In-frame_KIF3A_ENST00000378746_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_1110nt
GCGCAGGCGTAATTCAAGGGCCGAGAGAGCCTGAGACTGGGCTTGGGGCGGGGCGAGCTCGGAATGCGGCTGCGCACTGGGCGCTCTCGC
CCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCGCACCCGGTGTCGCTGGGCTGCACC
CCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGA
GACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTC
ACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCT
GAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCA
TATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCA
CCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAG
CCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCA
TCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTC
TGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCA
AGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCC

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_2284nt
CGGCTGCGCACTGGGCGCTCTCGCCCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCG
CACCCGGTGTCGCTGGGCTGCACCCCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCT
GCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGC
ATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAG
GCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGAT
GGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAG
ATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCC
GAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTA
GAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCCAGCAAGCTGGGCGCTCCGCTGAGCGGC
CTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGC
TTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCG
CGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGC
CTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGCTCCTCTGCTCCACCTTGAACCTGTCAC
CTGGCCTGCCACCCTCCTGCGCAGGCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGGTGCCAGGCATGTCCTAGGCTCTGGGTG
CAGTAGTGAGCAGGACGGGTACCATGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAGACCTGAATCACAACGGGCCAGCTCTAG
TAATACGAAGGTGAGGTCTGGGATGCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTGGGGTCAGGGAAAGTCTTAGCTGAGAAC
TAAGAGATGAGGGAGGCACAAACTCTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGGCGAGAAAGGCCTCTGTGGCCGTCATCG
GCACTAGCGGGTTGGGGGTGGTGGTGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGAGAGGGTGATTGAGTGTGGAGATCACCG
GGGCCGCCGCGGGCCGTCTGCACTTCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTTCTTCCACCCACGAGCACTTTATTCTCC
TCCGAGACCCCCTTTTCTTCCCCTTCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAGACAGAGACCAGAAGGAAGGTTTAGAAA
GAAAAGAACACTTGCCCAGGGCAGCTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAATTCCACCCCTCCTCGAAGTCCCGGCTT
CCACCCCTCTCCTCAGAGTCCCGGCGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGCCCCGGCTGCACACATCGTCTGTGAATT
GTGGCTGTTCACTCCCGAGGATGTGTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTTACTTGCTCGGGAGAAGAAACTGACTCG
TTTTATTTAGTGCCTATTTAGCGAGCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGTGCTATCGCAAATCACAAAAAAACTGTT
ATCAATTCACATTCATCATCAGCACGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATATTATGTTTCTTTTTTCATTTTTGCCAGT

>In-frame_KIF3A_ENST00000378735_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_1044nt
CGGCTGCGCACTGGGCGCTCTCGCCCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCG
CACCCGGTGTCGCTGGGCTGCACCCCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCT
GCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGC
ATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAG
GCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGAT
GGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAG
ATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCC
GAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTA
GAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACC
TCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACG
TGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGG

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000253754_chr5_131598302_+_2131nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCC
AGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCA
CGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGG
CTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTC
GTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGC
TCCTCTGCTCCACCTTGAACCTGTCACCTGGCCTGCCACCCTCCTGCGCAGGCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGG
TGCCAGGCATGTCCTAGGCTCTGGGTGCAGTAGTGAGCAGGACGGGTACCATGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAG
ACCTGAATCACAACGGGCCAGCTCTAGTAATACGAAGGTGAGGTCTGGGATGCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTG
GGGTCAGGGAAAGTCTTAGCTGAGAACTAAGAGATGAGGGAGGCACAAACTCTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGG
CGAGAAAGGCCTCTGTGGCCGTCATCGGCACTAGCGGGTTGGGGGTGGTGGTGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGA
GAGGGTGATTGAGTGTGGAGATCACCGGGGCCGCCGCGGGCCGTCTGCACTTCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTT
CTTCCACCCACGAGCACTTTATTCTCCTCCGAGACCCCCTTTTCTTCCCCTTCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAG
ACAGAGACCAGAAGGAAGGTTTAGAAAGAAAAGAACACTTGCCCAGGGCAGCTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAA
TTCCACCCCTCCTCGAAGTCCCGGCTTCCACCCCTCTCCTCAGAGTCCCGGCGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGC
CCCGGCTGCACACATCGTCTGTGAATTGTGGCTGTTCACTCCCGAGGATGTGTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTT
ACTTGCTCGGGAGAAGAAACTGACTCGTTTTATTTAGTGCCTATTTAGCGAGCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGT
GCTATCGCAAATCACAAAAAAACTGTTATCAATTCACATTCATCATCAGCACGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATAT

>In-frame_KIF3A_ENST00000403231_chr5_132073106_-_PDLIM4_ENST00000379018_chr5_131598302_+_891nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCT
TCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGC
GCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCC


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FusionGenePPI for KIF3A_PDLIM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF3AMAP3K10, MAP3K11, USP7, GRB2, PLEKHA5, DISC1, ARRB1, RANBP2, VHL, KIF3B, KIFAP3, NEK1, APP, LIG4, NOTCH1, CFTR, CASP1, OBFC1, DTNBP1, FASN, NTRK1, MED4, SCLT1, RAN, DHX34, GAK, KIF3C, RPA1, NUF2, CTNNBL1, FAM192A, SSH2, KIAA1279, H3F3B, TYW3, LYPLA2, HEPHL1, ATG9B, VSIG8, PKP3, DUSP14, EXOC3, PADI3, MFHAS1, HENMT1, SELENBP1, SSX2, LYG2, MAP1LC3B2, TRIM29, ZNF785, FAM26D, PLCD1, ALOX15B, APTX, RGS20, ACPP, TNFRSF8, ANXA8, ARL8A, PI4K2A, LRRC15, PREP, DSG4, SERPINB5, PKP1, HSDL2, DNPEP, XRCC4, DNAJC9, SSNA1, SLC9A3R2, CEP170, INTUPDLIM4RBPMS, ZNF408, EWSR1, KIR3DL2, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF3A_PDLIM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF3A_PDLIM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF3AC0004096Asthma1CTD_human
HgeneKIF3AC0005941Bone Diseases, Developmental1CTD_human
HgeneKIF3AC0152427Polydactyly1CTD_human
HgeneKIF3AC0376634Craniofacial Abnormalities1CTD_human
TgenePDLIM4C0032460Polycystic Ovary Syndrome1CTD_human