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Fusion gene ID: 18885 |
FusionGeneSummary for KIF2A_RNF180 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF2A_RNF180 | Fusion gene ID: 18885 | Hgene | Tgene | Gene symbol | KIF2A | RNF180 | Gene ID | 3796 | 285671 |
| Gene name | kinesin family member 2A | ring finger protein 180 | |
| Synonyms | CDCBM3|HK2|KIF2 | RINES | |
| Cytomap | 5q12.1 | 5q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2 | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00139 | Q86T96 | |
| Ensembl transtripts involved in fusion gene | ENST00000401507, ENST00000509663, ENST00000381103, ENST00000407818, ENST00000506857, | ENST00000389100, ENST00000296615, ENST00000381081, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 4 X 4=80 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIF2A [Title/Abstract] AND RNF180 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF2A | GO:0007052 | mitotic spindle organization | 18411309 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J9-A52D-01A | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000401507 | ENST00000389100 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5CDS-intron | ENST00000401507 | ENST00000296615 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5CDS-intron | ENST00000401507 | ENST00000381081 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 3UTR-3CDS | ENST00000509663 | ENST00000389100 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 3UTR-intron | ENST00000509663 | ENST00000296615 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 3UTR-intron | ENST00000509663 | ENST00000381081 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5UTR-3CDS | ENST00000381103 | ENST00000389100 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5UTR-intron | ENST00000381103 | ENST00000296615 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5UTR-intron | ENST00000381103 | ENST00000381081 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| Frame-shift | ENST00000407818 | ENST00000389100 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5CDS-intron | ENST00000407818 | ENST00000296615 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| 5CDS-intron | ENST00000407818 | ENST00000381081 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| intron-3CDS | ENST00000506857 | ENST00000389100 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| intron-intron | ENST00000506857 | ENST00000296615 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
| intron-intron | ENST00000506857 | ENST00000381081 | KIF2A | chr5 | 61602363 | + | RNF180 | chr5 | 63665442 | + |
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FusionProtFeatures for KIF2A_RNF180 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF2A | RNF180 |
| Plus end-directed microtubule-dependent motor requiredfor normal brain development. May regulate microtubule dynamicsduring axonal growth. Required for normal progression throughmitosis. Required for normal congress of chromosomes at themetaphase plate. Required for normal spindle dynamics duringmitosis. Promotes spindle turnover. Implicated in formation ofbipolar mitotic spindles. Has microtubule depolymerizationactivity. {ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}. | E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIF2A_RNF180 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIF2A_RNF180 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KIF2A | HDGF, NOTCH1, HIST3H3, STK4, WWOX, KIF2A, LARP1B, MRPL53, FAM13C, OBSL1, TSNAX, RPS6KB2, CHM, WBSCR22, NTRK1, EWSR1, PLK4, RPGRIP1L, CEP170, SPICE1, DCTN1, ACADVL, ALDH7A1, CSNK1E, GNS, ILK, TTK, KIF2C, LTN1, SKA1, MTRR, NFKBIL1, PRKCA, ROBO2, TIAL1, BAG6, UBL4A, EIF3F, TRAP1, CELF1, TRIOBP, EXOC3, MTF2, KIAA0556, ATP5S, UBR5, GET4, CEP192, WDR35, TMPRSS3, ZMYM1, SLC35E1, C2orf44, FIP1L1, CD99L2, GADD45GIP1, CEP170B, PES1, TP53, TYW3, RHPN1, KBTBD7, FGB, PTPN14 | RNF180 | ZIC2, LYN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIF2A_RNF180 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIF2A_RNF180 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KIF2A | C0025958 | Microcephaly | 1 | CTD_human |
| Hgene | KIF2A | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | KIF2A | C1955869 | Malformations of Cortical Development | 1 | CTD_human |
| Hgene | KIF2A | C3809414 | CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 3 | 1 | UNIPROT |
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