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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18884

FusionGeneSummary for KIF2A_ADAMTS19

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF2A_ADAMTS19
Fusion gene ID: 18884
HgeneTgene
Gene symbol

KIF2A

ADAMTS19

Gene ID

3796

171019

Gene namekinesin family member 2AADAM metallopeptidase with thrombospondin type 1 motif 19
SynonymsCDCBM3|HK2|KIF2-
Cytomap

5q12.1

5q23.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2A disintegrin and metalloproteinase with thrombospondin motifs 19a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19
Modification date2018052320180522
UniProtAcc

O00139

Q8TE59

Ensembl transtripts involved in fusion geneENST00000401507, ENST00000509663, 
ENST00000381103, ENST00000407818, 
ENST00000506857, 
ENST00000274487, 
ENST00000509467, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: KIF2A [Title/Abstract] AND ADAMTS19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF2A

GO:0007052

mitotic spindle organization

18411309


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7380-01AKIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000401507ENST00000274487KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
5CDS-intronENST00000401507ENST00000509467KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
3UTR-3CDSENST00000509663ENST00000274487KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
3UTR-intronENST00000509663ENST00000509467KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
5UTR-3CDSENST00000381103ENST00000274487KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
5UTR-intronENST00000381103ENST00000509467KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
Frame-shiftENST00000407818ENST00000274487KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
5CDS-intronENST00000407818ENST00000509467KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
intron-3CDSENST00000506857ENST00000274487KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+
intron-intronENST00000506857ENST00000509467KIF2Achr5

61602363

+ADAMTS19chr5

128956311

+

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FusionProtFeatures for KIF2A_ADAMTS19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF2A

O00139

ADAMTS19

Q8TE59

Plus end-directed microtubule-dependent motor requiredfor normal brain development. May regulate microtubule dynamicsduring axonal growth. Required for normal progression throughmitosis. Required for normal congress of chromosomes at themetaphase plate. Required for normal spindle dynamics duringmitosis. Promotes spindle turnover. Implicated in formation ofbipolar mitotic spindles. Has microtubule depolymerizationactivity. {ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF2A_ADAMTS19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF2A_ADAMTS19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF2AHDGF, NOTCH1, HIST3H3, STK4, WWOX, KIF2A, LARP1B, MRPL53, FAM13C, OBSL1, TSNAX, RPS6KB2, CHM, WBSCR22, NTRK1, EWSR1, PLK4, RPGRIP1L, CEP170, SPICE1, DCTN1, ACADVL, ALDH7A1, CSNK1E, GNS, ILK, TTK, KIF2C, LTN1, SKA1, MTRR, NFKBIL1, PRKCA, ROBO2, TIAL1, BAG6, UBL4A, EIF3F, TRAP1, CELF1, TRIOBP, EXOC3, MTF2, KIAA0556, ATP5S, UBR5, GET4, CEP192, WDR35, TMPRSS3, ZMYM1, SLC35E1, C2orf44, FIP1L1, CD99L2, GADD45GIP1, CEP170B, PES1, TP53, TYW3, RHPN1, KBTBD7, FGB, PTPN14ADAMTS19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF2A_ADAMTS19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF2A_ADAMTS19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF2AC0025958Microcephaly1CTD_human
HgeneKIF2AC0036341Schizophrenia1PSYGENET
HgeneKIF2AC1955869Malformations of Cortical Development1CTD_human
HgeneKIF2AC3809414CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 31UNIPROT