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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18867

FusionGeneSummary for KIF22_PRKCB

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF22_PRKCB
Fusion gene ID: 18867
HgeneTgene
Gene symbol

KIF22

PRKCB

Gene ID

3835

5579

Gene namekinesin family member 22protein kinase C beta
SynonymsA-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2PKC-beta|PKCB|PRKCB1|PRKCB2
Cytomap

16p11.2

16p12.2-p12.1

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding proteinprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide
Modification date2018052320180523
UniProtAcc

Q14807

P05771

Ensembl transtripts involved in fusion geneENST00000561482, ENST00000160827, 
ENST00000400750, ENST00000400751, 
ENST00000569382, ENST00000563263, 
ENST00000321728, ENST00000303531, 
ENST00000482000, ENST00000498058, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 9 X 10=1170
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/1170*10)=-3.0630097975258
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF22 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-R6-A6XG-01BKIF22chr16

29802150

+PRKCBchr16

24043457

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000561482ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-3CDSENST00000561482ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-intronENST00000561482ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-intronENST00000561482ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+
Frame-shiftENST00000160827ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
Frame-shiftENST00000160827ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
5CDS-intronENST00000160827ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
5CDS-intronENST00000160827ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-3CDSENST00000400750ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-3CDSENST00000400750ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-intronENST00000400750ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
5UTR-intronENST00000400750ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000400751ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000400751ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000400751ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000400751ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000569382ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000569382ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000569382ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000569382ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000563263ENST00000321728KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-3CDSENST00000563263ENST00000303531KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000563263ENST00000482000KIF22chr16

29802150

+PRKCBchr16

24043457

+
intron-intronENST00000563263ENST00000498058KIF22chr16

29802150

+PRKCBchr16

24043457

+

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FusionProtFeatures for KIF22_PRKCB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF22

Q14807

PRKCB

P05771

Kinesin family member that is involved in spindleformation and the movements of chromosomes during mitosis andmeiosis. Binds to microtubules and to DNA (By similarity). Plays arole in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869,ECO:0000269|PubMed:25743205}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF22_PRKCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF22_PRKCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF22SIAH1, GDF9, IMMT, PJA1, SVIL, CHFR, ATXN1, MOV10, NXF1, BRCA1, OBSL1, MAPK14, HIST1H2BG, HIST1H3A, C4A, CCNB1, FUS, SP110, RPL10, RBM45, KPNA3, KPNA4, LIMS1, PSEN2, STAT6, TAF12, MPDZ, COX5A, CEP350, BCL2L11, HMGXB4, MARCH6, CEPT1, CD2BP2, CKAP2, PHF21A, SFMBT1, EPB41L4B, BIRC6, ZNF668, C2orf44, CCNL2, C18orf21, UTP23, PSRC1, CIRH1A, KNSTRN, PGM2L1, TEAD2, FOXE1, FOXL1, FOXM1, FOXQ1, CDC14B, TBC1D15, CNPY2, USP47, ZYG11BPRKCBRASGRP3, NCAM1, ADRBK1, BTK, GNB2L1, CSF2RB, YWHAG, GNA12, GNA13, RIPK4, RGS2, TIAM1, PDLIM5, NCF1, PDPK1, AFAP1, LMNB1, CDK1, RBCK1, HSPA4, IKBKG, HIST1H3A, PRKCB, DDX58, TRIM41, EGFR, TERF1, TINF2, RNF31, IBTK, KCNA5, TOP2A, HIST1H1A, LSP1, H1F0, CARD11, SDC2, ITGB2, PPP2R4, PPP1CA, TNFRSF1A, FN1, HSP90AA1, GSK3A, CASR, RB1, SYT6, HIST1H1B, MARCKS, NUMB, LYN, MBP, PRKCD, EP300, SHCBP1, DAB2, AKT1, IKBKB, CHUK, GSK3B, ARRB2, ITGB3, PRKCA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF22_PRKCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePRKCBP05771DB08862CholecystokininProtein kinase C beta typesmall moleculeapproved|investigational

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RelatedDiseases for KIF22_PRKCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF22C1863732Spondyloepimetaphyseal dysplasia with multiple dislocations2ORPHANET;UNIPROT
TgenePRKCBC0004352Autistic Disorder1CTD_human
TgenePRKCBC0009404Colorectal Neoplasms1CTD_human
TgenePRKCBC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgenePRKCBC0018800Cardiomegaly1CTD_human
TgenePRKCBC0020456Hyperglycemia1CTD_human
TgenePRKCBC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgenePRKCBC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePRKCBC0038356Stomach Neoplasms1CTD_human
TgenePRKCBC0041696Unipolar Depression1PSYGENET
TgenePRKCBC1269683Major Depressive Disorder1PSYGENET