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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 18864

FusionGeneSummary for KIF21B_ANP32B

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF21B_ANP32B
Fusion gene ID: 18864
HgeneTgene
Gene symbol

KIF21B

ANP32B

Gene ID

23046

10541

Gene namekinesin family member 21Bacidic nuclear phosphoprotein 32 family member B
Synonyms-APRIL|PHAPI2|SSP29
Cytomap

1q32.1

9q22.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF21Bacidic leucine-rich nuclear phosphoprotein 32 family member Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member Bacidic protein rich in leucinesputative HLA-DR-associated protein I-2silver-stainable protein SSP29
Modification date2018052320180523
UniProtAcc

O75037

Q92688

Ensembl transtripts involved in fusion geneENST00000332129, ENST00000360529, 
ENST00000461742, ENST00000422435, 
ENST00000339399, ENST00000473205, 
Fusion gene scores* DoF score3 X 2 X 2=126 X 6 X 3=108
# samples 37
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF21B [Title/Abstract] AND ANP32B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANP32B

GO:0006334

nucleosome assembly

20538007

TgeneANP32B

GO:0045596

negative regulation of cell differentiation

22705300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-8163-01AKIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000332129ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000332129ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000360529ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000360529ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000461742ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000461742ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000422435ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000422435ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+

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FusionProtFeatures for KIF21B_ANP32B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF21B

O75037

ANP32B

Q92688

Plus-end directed microtubule-dependent motor proteinwhich displays processive activity. Is involved in regulation ofmicrotubule dynamics, synapse function and neuronal morphology,including dendritic tree branching and spine formation. Plays arole in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.{ECO:0000250|UniProtKB:Q9QXL1}. Multifunctional protein working as a cell cycleprogression factor as well as a cell survival factor. Required forthe progression from the G1 to the S phase. Anti-apoptotic proteinwhich functions as a caspase-3 inhibitor. Has no phosphatase 2A(PP2A) inhibitor activity (By similarity). Exhibits histonechaperone properties, stimulating core histones to assemble into anucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+07146_25118252Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+07123_16118252DomainNote=LRRCT
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+0716_4018252RepeatLRR 1
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+0743_6418252RepeatLRR 2
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+0765_8418252RepeatLRR 3
TgeneANP32Bchr1:200992471chr9:100756913ENST00000339399+0789_11018252RepeatLRR 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134376_604131625Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134631_824131625Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134928_1016131625Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134376_604131611Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134631_824131611Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134928_1016131611Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135376_604131638Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135631_824131638Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135928_1016131638Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135376_604131624Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135631_824131624Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135928_1016131624Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1348_370131625DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1348_370131611DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1358_370131638DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1358_370131624DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-13487_94131625Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-13487_94131611Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-13587_94131638Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-13587_94131624Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341306_1343131625RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341346_1384131625RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341410_1448131625RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341451_1493131625RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341502_1539131625RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341543_1582131625RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341585_1622131625RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341306_1343131611RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341346_1384131611RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341410_1448131611RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341451_1493131611RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341502_1539131611RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341543_1582131611RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341585_1622131611RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351306_1343131638RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351346_1384131638RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351410_1448131638RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351451_1493131638RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351502_1539131638RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351543_1582131638RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351585_1622131638RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351306_1343131624RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351346_1384131624RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351410_1448131624RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351451_1493131624RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351502_1539131624RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351543_1582131624RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351585_1622131624RepeatNote=WD 7


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FusionGeneSequence for KIF21B_ANP32B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KIF21B_ENST00000332129_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_247aa
MAGQGDCCVKVAVRFENLSWTIANQMMEKLRAXQLNLXTXSSSVXXMXAXSQFQISPSCLNXKSLNSVKIESLEVWTCXLKNFQISHIXT
XVEINXKISAPWNLXKSXNVXKAWTSLTVRLPTXMTTERVSSSSCPSLPTWMAMTERTRKHLTQMPRWMVWMKRRRTKKEKMRKTRTMRM

>In-frame_KIF21B_ENST00000360529_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_247aa
MAGQGDCCVKVAVRFENLSWTIANQMMEKLRAXQLNLXTXSSSVXXMXAXSQFQISPSCLNXKSLNSVKIESLEVWTCXLKNFQISHIXT
XVEINXKISAPWNLXKSXNVXKAWTSLTVRLPTXMTTERVSSSSCPSLPTWMAMTERTRKHLTQMPRWMVWMKRRRTKKEKMRKTRTMRM

>In-frame_KIF21B_ENST00000461742_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_247aa
MAGQGDCCVKVAVRFENLSWTIANQMMEKLRAXQLNLXTXSSSVXXMXAXSQFQISPSCLNXKSLNSVKIESLEVWTCXLKNFQISHIXT
XVEINXKISAPWNLXKSXNVXKAWTSLTVRLPTXMTTERVSSSSCPSLPTWMAMTERTRKHLTQMPRWMVWMKRRRTKKEKMRKTRTMRM

>In-frame_KIF21B_ENST00000422435_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_247aa
MAGQGDCCVKVAVRFENLSWTIANQMMEKLRAXQLNLXTXSSSVXXMXAXSQFQISPSCLNXKSLNSVKIESLEVWTCXLKNFQISHIXT
XVEINXKISAPWNLXKSXNVXKAWTSLTVRLPTXMTTERVSSSSCPSLPTWMAMTERTRKHLTQMPRWMVWMKRRRTKKEKMRKTRTMRM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KIF21B_ENST00000332129_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_743nt
ATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTG
AGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTA
AATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACT
TAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGG
TTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAG
CACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATG
GTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAG
AATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAG

>In-frame_KIF21B_ENST00000360529_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_743nt
ATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTG
AGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTA
AATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACT
TAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGG
TTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAG
CACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATG
GTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAG
AATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAG

>In-frame_KIF21B_ENST00000461742_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_743nt
ATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTG
AGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTA
AATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACT
TAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGG
TTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAG
CACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATG
GTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAG
AATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAG

>In-frame_KIF21B_ENST00000422435_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_743nt
ATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTG
AGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTA
AATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACT
TAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGG
TTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAG
CACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATG
GTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAG
AATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KIF21B_ENST00000332129_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_1572nt
GGGAGGTGGCTGCCGGGTGGGAGGTGTGTGCGCGTGTGCCGCGCCGTAGGGAGCGGCGGGTCGCGCCGCCGGCTGTCAGCTAGCTCCGCG
CCGCCGCCCGATGGCGCGAGGAGGCGCGCGGGCCCAGCCCCGGGGGGCCGGCCGCGGGTGAGCCCCTCGGCCTGCCGCCCGCGAGCATGT
CACCTCCAGCCGCCGCCGCCGCAGCCTCCGCCAGCCGCGCCCGCGCCCCCGCCTCCCGCAGCCGCAGCCGCTGCCTCGGGCATTGGCCCC
CAGACCCCCGCCTCTGATCCACGCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGT
TCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTT
AATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGG
TCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTT
GAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCT
GCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGA
GGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGA
TGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGA
AGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGA
AACAGAACTGTTCAGTATTGGTTGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGA
CACCCACCCACCCAAAGAGCCAAAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTT
GTGGACTTCACCCCAACAAAATTGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAA
CCGTCTGTGGCTACCAGTTACACTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTT
TGGGTCTGTTTTTTCATGCTTTGCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTAT

>In-frame_KIF21B_ENST00000360529_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_1280nt
GCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAAT
TGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCA
GTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAA
CTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAA
AGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGAT
GGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGAT
GAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGAC
GATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAA
GGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGAAACAGAACTGTTCAGTATTGGT
TGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGACACCCACCCACCCAAAGAGCCA
AAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTTGTGGACTTCACCCCAACAAAAT
TGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAACCGTCTGTGGCTACCAGTTACA
CTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTTTGGGTCTGTTTTTTCATGCTTT
GCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTATTTTTAAGAATTTAAGCGAAATA

>In-frame_KIF21B_ENST00000461742_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_1280nt
GCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAAT
TGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCA
GTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAA
CTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAA
AGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGAT
GGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGAT
GAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGAC
GATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAA
GGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGAAACAGAACTGTTCAGTATTGGT
TGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGACACCCACCCACCCAAAGAGCCA
AAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTTGTGGACTTCACCCCAACAAAAT
TGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAACCGTCTGTGGCTACCAGTTACA
CTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTTTGGGTCTGTTTTTTCATGCTTT
GCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTATTTTTAAGAATTTAAGCGAAATA

>In-frame_KIF21B_ENST00000422435_chr1_200992471_-_ANP32B_ENST00000339399_chr9_100756913_+_1572nt
GGGAGGTGGCTGCCGGGTGGGAGGTGTGTGCGCGTGTGCCGCGCCGTAGGGAGCGGCGGGTCGCGCCGCCGGCTGTCAGCTAGCTCCGCG
CCGCCGCCCGATGGCGCGAGGAGGCGCGCGGGCCCAGCCCCGGGGGGCCGGCCGCGGGTGAGCCCCTCGGCCTGCCGCCCGCGAGCATGT
CACCTCCAGCCGCCGCCGCCGCAGCCTCCGCCAGCCGCGCCCGCGCCCCCGCCTCCCGCAGCCGCAGCCGCTGCCTCGGGCATTGGCCCC
CAGACCCCCGCCTCTGATCCACGCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGT
TCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTT
AATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGG
TCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTT
GAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCT
GCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGA
GGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGA
TGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGA
AGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGA
AACAGAACTGTTCAGTATTGGTTGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGA
CACCCACCCACCCAAAGAGCCAAAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTT
GTGGACTTCACCCCAACAAAATTGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAA
CCGTCTGTGGCTACCAGTTACACTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTT
TGGGTCTGTTTTTTCATGCTTTGCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTAT


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FusionGenePPI for KIF21B_ANP32B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF21BUBC, TK1, TRIM3, BTD, CAPG, COL4A5, CSTF2, TAF5, TAF12, TBX3, BAG6, UBL4A, FUBP3, SYNCRIP, NUDT21, ZNF281, TMEM248, HAUS2, USF1, PRPF6, MED4, CPSF1, CPSF3, POLE3, KIF21A, P3H1, WDR75, TICAM1, GAN, PMF1ANP32BMEPCE, CHAF1A, UCHL5, PIDD1, ELAVL1, APP, VCAM1, FN1, CSNK2A1, CDH1, ITGA4, CD81, IGSF8, ICAM1, SOX2, HNF4A, KPNA1, SMARCD1, SMAD2, ACTR2, ACTR3, ARPC5, BAG1, CALR, DHPS, KIAA1279, ARPC1B, ARPC2, GRPEL1, RPA1, SH3GL1, HUWE1, KPNA5, MEOX2, SDCBP, ESR1, AHCYL1, AHCYL2, ANP32A, ATP1B3, NCL, DMAP1, VPS72, NTRK1, KLF5, HIST1H2AA, HIST1H2BA, HIST1H3A, HIST1H4A, XPO1, EWSR1, FAM3A, CDC73, PTPN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134400_1099131625TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134400_1099131611TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135400_1099131638TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135400_1099131624TRIM3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF21B_ANP32B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF21B_ANP32B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF21BC0009324Ulcerative Colitis1CTD_human