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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18819

FusionGeneSummary for KIF16B_SNX5

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF16B_SNX5
Fusion gene ID: 18819
HgeneTgene
Gene symbol

KIF16B

SNX5

Gene ID

55614

27131

Gene namekinesin family member 16Bsorting nexin 5
SynonymsC20orf23|KISC20ORF|SNX23-
Cytomap

20p12.1

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201asorting nexin-5
Modification date2018052320180522
UniProtAcc

Q96L93

Q9Y5X3

Ensembl transtripts involved in fusion geneENST00000354981, ENST00000378003, 
ENST00000355755, ENST00000408042, 
ENST00000483485, ENST00000377759, 
ENST00000377768, ENST00000606557, 
ENST00000606602, ENST00000481323, 
ENST00000486039, 
Fusion gene scores* DoF score6 X 6 X 6=2162 X 2 X 2=8
# samples 72
** MAII scorelog2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KIF16B [Title/Abstract] AND SNX5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSNX5

GO:0006907

pinocytosis

18854019


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-CM-6164-01AKIF16Bchr20

16506737

-SNX5chr20

17923839

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354981ENST00000483485KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000354981ENST00000377759KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000354981ENST00000377768KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000354981ENST00000606557KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000354981ENST00000606602KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000354981ENST00000481323KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000354981ENST00000486039KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-5UTRENST00000378003ENST00000483485KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-5UTRENST00000378003ENST00000377759KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-5UTRENST00000378003ENST00000377768KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-intronENST00000378003ENST00000606557KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-intronENST00000378003ENST00000606602KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-intronENST00000378003ENST00000481323KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5UTR-intronENST00000378003ENST00000486039KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000355755ENST00000483485KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000355755ENST00000377759KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000355755ENST00000377768KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000355755ENST00000606557KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000355755ENST00000606602KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000355755ENST00000481323KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000355755ENST00000486039KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000408042ENST00000483485KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000408042ENST00000377759KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-5UTRENST00000408042ENST00000377768KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000408042ENST00000606557KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000408042ENST00000606602KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000408042ENST00000481323KIF16Bchr20

16506737

-SNX5chr20

17923839

-
5CDS-intronENST00000408042ENST00000486039KIF16Bchr20

16506737

-SNX5chr20

17923839

-

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FusionProtFeatures for KIF16B_SNX5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF16B

Q96L93

SNX5

Q9Y5X3

Involved in several stages of intracellular trafficking.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component ofthe retromer membrane-deforming SNX-BAR subcomplex. The SNX-BARretromer mediates retrograde transport of cargo proteins fromendosomes to the trans-Golgi network (TGN) and is involved inendosome-to-plasma membrane transport for cargo protein recycling.The SNX-BAR subcomplex functions to deform the donor membrane intoa tubular profile called endosome-to-TGN transport carrier (ETC)(Probable). Does not have in vitro vesicle-to-membrane remodelingactivity (PubMed:23085988). Involved in retrograde transport oflysosomal enzyme receptor IGF2R (PubMed:17148574,PubMed:18596235). May function as link between endosomal transportvesicles and dynactin (Probable). Plays a role in theinternalization of EGFR after EGF stimulation (Probable). Involvedin EGFR endosomal sorting and degradation; the function involvesPIP5K1C isoform 3 and is retromer-independent (PubMed:23602387).Together with PIP5K1C isoform 3 facilitates HGS interaction withubiquitinated EGFR, which initiates EGFR sorting to intraluminalvesicles (ILVs) of the multivesicular body for subsequentlysosomal degradation (Probable). Involved in E-cadherin sortingand degradation; inhibits PIP5K1C isoform 3-mediated E-cadherindegradation (PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942,ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496,ECO:0000303|PubMed:23085988}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF16B_SNX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF16B_SNX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF16BITSN1, AURKA, GAR1, ENTHD2, MON1B, KIAA1279, ALOX5, CCZ1, SPAG9, CARM1SNX5CLTCL1, CLTC, ITSN1, FANCA, HMOX2, MESDC2, DNAJB11, CDC37, PRKRA, PFDN1, MIB1, VPS33B, PIP5K1C, HGS, SNX2, STK4, ARFIP2, NUP155, BOP1, ELAC2, SARS, XPO5, APPBP2, LAPTM4B, BIN3, GAS2L1, BLVRA, FAM221A, C11orf42, DNM3, GNAT2, FAM90A1, VAPB, SNX1, SCLT1, CDH1, C1orf87, CCDC102B, TEX28, KLHL10, HCLS1, GTF2E2, MLX, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF16B_SNX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF16B_SNX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSNX5C0038356Stomach Neoplasms1CTD_human