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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18817

FusionGeneSummary for KIF16B_PLCB1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF16B_PLCB1
Fusion gene ID: 18817
HgeneTgene
Gene symbol

KIF16B

PLCB1

Gene ID

55614

23236

Gene namekinesin family member 16Bphospholipase C beta 1
SynonymsC20orf23|KISC20ORF|SNX23EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B
Cytomap

20p12.1

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphospholipase C, beta 1 (phosphoinositide-specific
Modification date2018052320180519
UniProtAcc

Q96L93

Q9NQ66

Ensembl transtripts involved in fusion geneENST00000354981, ENST00000378003, 
ENST00000355755, ENST00000408042, 
ENST00000378641, ENST00000338037, 
ENST00000378637, ENST00000494924, 
Fusion gene scores* DoF score6 X 6 X 6=2166 X 5 X 4=120
# samples 75
** MAII scorelog2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF16B [Title/Abstract] AND PLCB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLCB1

GO:0035722

interleukin-12-mediated signaling pathway

11743656

TgenePLCB1

GO:0035723

interleukin-15-mediated signaling pathway

11743656

TgenePLCB1

GO:0046330

positive regulation of JNK cascade

9500449

TgenePLCB1

GO:0070498

interleukin-1-mediated signaling pathway

8872139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1FH-01AKIF16Bchr20

16553874

-PLCB1chr20

8665579

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000354981ENST00000378641KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000354981ENST00000338037KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000354981ENST00000378637KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5CDS-intronENST00000354981ENST00000494924KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5UTR-3CDSENST00000378003ENST00000378641KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5UTR-3CDSENST00000378003ENST00000338037KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5UTR-3CDSENST00000378003ENST00000378637KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5UTR-intronENST00000378003ENST00000494924KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000355755ENST00000378641KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000355755ENST00000338037KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000355755ENST00000378637KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5CDS-intronENST00000355755ENST00000494924KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000408042ENST00000378641KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000408042ENST00000338037KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
Frame-shiftENST00000408042ENST00000378637KIF16Bchr20

16553874

-PLCB1chr20

8665579

+
5CDS-intronENST00000408042ENST00000494924KIF16Bchr20

16553874

-PLCB1chr20

8665579

+

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FusionProtFeatures for KIF16B_PLCB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF16B

Q96L93

PLCB1

Q9NQ66


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIF16B_PLCB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIF16B_PLCB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIF16BITSN1, AURKA, GAR1, ENTHD2, MON1B, KIAA1279, ALOX5, CCZ1, SPAG9, CARM1PLCB1TRPM7, SLC9A3R1, SPTBN1, KRIT1, PCF11, GNA11, GNAQ, PLCB1, CTBP1, CTBP2, TFCP2, CEP76, BTN2A1, PTGER3, GAN, DEF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIF16B_PLCB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIF16B_PLCB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLCB1C0005586Bipolar Disorder1PSYGENET
TgenePLCB1C0009375Colonic Neoplasms1CTD_human
TgenePLCB1C0030193Pain1CTD_human
TgenePLCB1C0036341Schizophrenia1CTD_human
TgenePLCB1C0041696Unipolar Depression1PSYGENET
TgenePLCB1C1269683Major Depressive Disorder1PSYGENET
TgenePLCB1C3463824MYELODYSPLASTIC SYNDROME1CTD_human