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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18765

FusionGeneSummary for KIAA2026_C2orf74

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA2026_C2orf74
Fusion gene ID: 18765
HgeneTgene
Gene symbol

KIAA2026

C2orf74

Gene ID

158358

339804

Gene nameKIAA2026chromosome 2 open reading frame 74
Synonyms--
Cytomap

9p24.1

2p15

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA2026uncharacterized protein C2orf74
Modification date2018051920180519
UniProtAcc

Q5HYC2

A8MZ97

Ensembl transtripts involved in fusion geneENST00000443149, ENST00000399933, 
ENST00000381461, 
ENST00000426997, 
ENST00000432605, 
Fusion gene scores* DoF score10 X 9 X 5=4505 X 4 X 5=100
# samples 106
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA2026 [Title/Abstract] AND C2orf74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC108654KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000443149ENST00000426997KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
intron-3UTRENST00000443149ENST00000432605KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
intron-3UTRENST00000399933ENST00000426997KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
intron-3UTRENST00000399933ENST00000432605KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
intron-3UTRENST00000381461ENST00000426997KIAA2026chr9

5922478

-C2orf74chr2

61391744

+
intron-3UTRENST00000381461ENST00000432605KIAA2026chr9

5922478

-C2orf74chr2

61391744

+

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FusionProtFeatures for KIAA2026_C2orf74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA2026

Q5HYC2

C2orf74

A8MZ97


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA2026_C2orf74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA2026_C2orf74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA2026_C2orf74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA2026_C2orf74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource