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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18688

FusionGeneSummary for KIAA1328_QSER1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1328_QSER1
Fusion gene ID: 18688
HgeneTgene
Gene symbol

KIAA1328

QSER1

Gene ID

57536

79832

Gene nameKIAA1328glutamine and serine rich 1
Synonyms--
Cytomap

18q12.2

11p13

Type of geneprotein-codingprotein-coding
Descriptionprotein hinderinhinderinglutamine and serine-rich protein 1
Modification date2018051920180519
UniProtAcc

Q86T90

Q2KHR3

Ensembl transtripts involved in fusion geneENST00000543923, ENST00000435985, 
ENST00000280020, ENST00000591619, 
ENST00000586135, ENST00000592521, 
ENST00000586501, ENST00000601437, 
ENST00000399302, ENST00000527250, 
ENST00000527788, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 5 X 3=60
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1328 [Title/Abstract] AND QSER1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-3917-01AKIAA1328chr18

34505005

+QSER1chr11

32948703

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000543923ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000543923ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000543923ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000435985ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000435985ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000435985ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000280020ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000280020ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000280020ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000591619ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000591619ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000591619ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
5UTR-5UTRENST00000586135ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
5UTR-3UTRENST00000586135ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
5UTR-5UTRENST00000586135ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000592521ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000592521ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000592521ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000586501ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000586501ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000586501ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000601437ENST00000399302KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-3UTRENST00000601437ENST00000527250KIAA1328chr18

34505005

+QSER1chr11

32948703

+
intron-5UTRENST00000601437ENST00000527788KIAA1328chr18

34505005

+QSER1chr11

32948703

+

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FusionProtFeatures for KIAA1328_QSER1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1328

Q86T90

QSER1

Q2KHR3

Competes with SMC1 for binding to SMC3. May affect theavailability of SMC3 to engage in the formation of multimericprotein complexes. {ECO:0000269|PubMed:15656913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1328_QSER1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1328_QSER1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1328APC, PCM1, OFD1, CEP135, FGFR1OP, CCDC14, CDC14AQSER1SOX2, MAGEA10, FHL3, FAM170A, HNRNPH2, PDLIM7, FBXO31, FOXJ2, FOXP1, C11orf30, PHF12, GATAD1, COMMD8, HSPBP1, PLEC, AAK1, SEC24B, CCDC88A, EYA4, UBE2D2, BRD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1328_QSER1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1328_QSER1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource