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Fusion gene ID: 1868 |
FusionGeneSummary for ANKRD52_ASPHD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD52_ASPHD1 | Fusion gene ID: 1868 | Hgene | Tgene | Gene symbol | ANKRD52 | ASPHD1 | Gene ID | 283373 | 253982 |
| Gene name | ankyrin repeat domain 52 | aspartate beta-hydroxylase domain containing 1 | |
| Synonyms | ANKRD33 | - | |
| Cytomap | 12q13.3 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit CCVWG5837PP6-ARS-Cankyrin repeat domain 33ankyrin repeat domain-containing protein 52protein phosphatase 6 ankyrin repeat subunit Cserine/threonine-protein phosphatase 6 regula | aspartate beta-hydroxylase domain-containing protein 1 | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | Q8NB46 | Q5U4P2 | |
| Ensembl transtripts involved in fusion gene | ENST00000548241, ENST00000267116, | ENST00000483405, ENST00000308748, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANKRD52 [Title/Abstract] AND ASPHD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-MX-A666-01A | ANKRD52 | chr12 | 56649568 | - | ASPHD1 | chr16 | 29917109 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000548241 | ENST00000483405 | ANKRD52 | chr12 | 56649568 | - | ASPHD1 | chr16 | 29917109 | + |
| intron-3CDS | ENST00000548241 | ENST00000308748 | ANKRD52 | chr12 | 56649568 | - | ASPHD1 | chr16 | 29917109 | + |
| In-frame | ENST00000267116 | ENST00000483405 | ANKRD52 | chr12 | 56649568 | - | ASPHD1 | chr16 | 29917109 | + |
| In-frame | ENST00000267116 | ENST00000308748 | ANKRD52 | chr12 | 56649568 | - | ASPHD1 | chr16 | 29917109 | + |
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FusionProtFeatures for ANKRD52_ASPHD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD52 | ASPHD1 |
| Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANKRD52_ASPHD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000483405_chr16_29917109_+_190aa MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVL GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLEAPPKMGLEWSSSWTSGTPTWQGLSAR >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000308748_chr16_29917109_+_190aa MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVL GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLEAPPKMGLEWSSSWTSGTPTWQGLSAR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000483405_chr16_29917109_+_572nt ATGGGGATCCTCAGCATCACGGACCAGCCGCCCCTGGTCCAGGCCATCTTTAGCCGAGATGTGGAGGAAGTGCGTTCCCTACTCTCGCAG AAGGAGAACATCAATGTGCTGGACCAAGAGAGGCGAACTCCATTGCATGCTGCTGCCTACGTAGGCGATGTCCCCATCCTCCAGTTGCTA CTGATGTCAGGTGCTAATGTCAATGCTAAGGACACACTGTGGCTGACCCCTCTTCATCGTGCTGCTGCCTCCCGAAACGAGAAGGTGCTG GGGCTGCTGCTGGCACATTCAGCAGATGTGAATGCCCGGGACAAGCTGTGGCAGACACCACTGCATGTGGCTGCTGCCAACCGGGCCACC AAGTGTGCTGAGGCTCTGGCACCCCTGTTGAGCAGCCTCAACGTGGCTGACAGGAGCGGGCGCAGTGCTCTGCACCATGCAGTGCATAGT GGGCATCTTGAGGCTCCCCCGAAGATGGGCCTCGAGTGGTCTTCATCGTGGACCTCTGGCACCCCAACGTGGCAGGGGCTGAGCGCCAGG >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000308748_chr16_29917109_+_572nt ATGGGGATCCTCAGCATCACGGACCAGCCGCCCCTGGTCCAGGCCATCTTTAGCCGAGATGTGGAGGAAGTGCGTTCCCTACTCTCGCAG AAGGAGAACATCAATGTGCTGGACCAAGAGAGGCGAACTCCATTGCATGCTGCTGCCTACGTAGGCGATGTCCCCATCCTCCAGTTGCTA CTGATGTCAGGTGCTAATGTCAATGCTAAGGACACACTGTGGCTGACCCCTCTTCATCGTGCTGCTGCCTCCCGAAACGAGAAGGTGCTG GGGCTGCTGCTGGCACATTCAGCAGATGTGAATGCCCGGGACAAGCTGTGGCAGACACCACTGCATGTGGCTGCTGCCAACCGGGCCACC AAGTGTGCTGAGGCTCTGGCACCCCTGTTGAGCAGCCTCAACGTGGCTGACAGGAGCGGGCGCAGTGCTCTGCACCATGCAGTGCATAGT GGGCATCTTGAGGCTCCCCCGAAGATGGGCCTCGAGTGGTCTTCATCGTGGACCTCTGGCACCCCAACGTGGCAGGGGCTGAGCGCCAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000483405_chr16_29917109_+_853nt AGGCGGGGCCGCGCTCTCCCTGCAGCCGCCACCGCAGCCGCCGCCTGGGCCGCTCCGTGTCCCCGGTGGAGCCGCCGCCGCCGCCGCCGG GAGCTCGATGCGGACGGAGCCCGGGCCGAGCCATGGGGATCCTCAGCATCACGGACCAGCCGCCCCTGGTCCAGGCCATCTTTAGCCGAG ATGTGGAGGAAGTGCGTTCCCTACTCTCGCAGAAGGAGAACATCAATGTGCTGGACCAAGAGAGGCGAACTCCATTGCATGCTGCTGCCT ACGTAGGCGATGTCCCCATCCTCCAGTTGCTACTGATGTCAGGTGCTAATGTCAATGCTAAGGACACACTGTGGCTGACCCCTCTTCATC GTGCTGCTGCCTCCCGAAACGAGAAGGTGCTGGGGCTGCTGCTGGCACATTCAGCAGATGTGAATGCCCGGGACAAGCTGTGGCAGACAC CACTGCATGTGGCTGCTGCCAACCGGGCCACCAAGTGTGCTGAGGCTCTGGCACCCCTGTTGAGCAGCCTCAACGTGGCTGACAGGAGCG GGCGCAGTGCTCTGCACCATGCAGTGCATAGTGGGCATCTTGAGGCTCCCCCGAAGATGGGCCTCGAGTGGTCTTCATCGTGGACCTCTG GCACCCCAACGTGGCAGGGGCTGAGCGCCAGGCCCTCGACTTTGTCTTCGCCCCAGACCCTTGAAGGAAGGTGCTCCCTTCACACACCCA GGCTGGAGAGACACTGCGCTCAGGGACGGCTTGATGGTAGCCAGGACCTCCTCTCTACTGCGGGGGTGGGCGGGGGCGGAGGATGGGAAC >In-frame_ANKRD52_ENST00000267116_chr12_56649568_-_ASPHD1_ENST00000308748_chr16_29917109_+_853nt AGGCGGGGCCGCGCTCTCCCTGCAGCCGCCACCGCAGCCGCCGCCTGGGCCGCTCCGTGTCCCCGGTGGAGCCGCCGCCGCCGCCGCCGG GAGCTCGATGCGGACGGAGCCCGGGCCGAGCCATGGGGATCCTCAGCATCACGGACCAGCCGCCCCTGGTCCAGGCCATCTTTAGCCGAG ATGTGGAGGAAGTGCGTTCCCTACTCTCGCAGAAGGAGAACATCAATGTGCTGGACCAAGAGAGGCGAACTCCATTGCATGCTGCTGCCT ACGTAGGCGATGTCCCCATCCTCCAGTTGCTACTGATGTCAGGTGCTAATGTCAATGCTAAGGACACACTGTGGCTGACCCCTCTTCATC GTGCTGCTGCCTCCCGAAACGAGAAGGTGCTGGGGCTGCTGCTGGCACATTCAGCAGATGTGAATGCCCGGGACAAGCTGTGGCAGACAC CACTGCATGTGGCTGCTGCCAACCGGGCCACCAAGTGTGCTGAGGCTCTGGCACCCCTGTTGAGCAGCCTCAACGTGGCTGACAGGAGCG GGCGCAGTGCTCTGCACCATGCAGTGCATAGTGGGCATCTTGAGGCTCCCCCGAAGATGGGCCTCGAGTGGTCTTCATCGTGGACCTCTG GCACCCCAACGTGGCAGGGGCTGAGCGCCAGGCCCTCGACTTTGTCTTCGCCCCAGACCCTTGAAGGAAGGTGCTCCCTTCACACACCCA GGCTGGAGAGACACTGCGCTCAGGGACGGCTTGATGGTAGCCAGGACCTCCTCTCTACTGCGGGGGTGGGCGGGGGCGGAGGATGGGAAC |
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FusionGenePPI for ANKRD52_ASPHD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANKRD52 | USP36, USP49, PLK1, PPP6C, SIRT7, MOB1A, MOB1B, PPP6R1, PPP6R2, PPP6R3, MOV10, NXF1, AP2M1, DCLRE1C, CEP44, XPO1, FOXK1, FOXK2, HIF1AN, ZNF785, USP10, TRMT2A, ZNF263, ZNF414, CPNE5, ZNF669, FAM19A3, ZNF223, FOXD4, KIF2B, CAMK4, TRIM25 | ASPHD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANKRD52_ASPHD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD52_ASPHD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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