FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 18675

FusionGeneSummary for KIAA1217_LPP

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1217_LPP
Fusion gene ID: 18675
HgeneTgene
Gene symbol

KIAA1217

LPP

Gene ID

56243

4026

Gene nameKIAA1217LIM domain containing preferred translocation partner in lipoma
SynonymsETL4|SKT-
Cytomap

10p12.2-p12.1

3q27.3-q28

Type of geneprotein-codingprotein-coding
Descriptionsickle tail protein homologlikely orthologue of Mus musculus enhancer trap locus 4lipoma-preferred partnerLIM proteinlipoma preferred partner
Modification date2018051920180519
UniProtAcc

Q5T5P2

Q93052

Ensembl transtripts involved in fusion geneENST00000376462, ENST00000481700, 
ENST00000458595, ENST00000376454, 
ENST00000376452, ENST00000430453, 
ENST00000307544, ENST00000396446, 
ENST00000396445, ENST00000376451, 
ENST00000448637, ENST00000312675, 
ENST00000543006, ENST00000471917, 
Fusion gene scores* DoF score10 X 10 X 6=60012 X 17 X 5=1020
# samples 1120
** MAII scorelog2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1020*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1217 [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-NC-A5HP-01AKIAA1217chr10

24528266

+LPPchr3

188242453

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000376462ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376462ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376462ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000376462ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000481700ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000481700ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000481700ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000481700ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000458595ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000458595ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000458595ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000458595ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376454ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376454ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376454ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000376454ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376452ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376452ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376452ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000376452ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000430453ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000430453ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000430453ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000430453ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000307544ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000307544ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000307544ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000307544ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396446ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396446ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396446ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000396446ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396445ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396445ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000396445ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000396445ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376451ENST00000448637KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376451ENST00000312675KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-3CDSENST00000376451ENST00000543006KIAA1217chr10

24528266

+LPPchr3

188242453

+
intron-intronENST00000376451ENST00000471917KIAA1217chr10

24528266

+LPPchr3

188242453

+

Top

FusionProtFeatures for KIAA1217_LPP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1217

Q5T5P2

LPP

Q93052

May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KIAA1217_LPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for KIAA1217_LPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1217SORBS3, NCK2, EXOSC5, TEX11, GCC1, KRT15, FXR2, FHL2, GOLGA2, HSBP1, VPS52, SIAH1, TRAF1, ABI2, SHMT2, MICU2, HNRNPLL, NARS, CNTROB, NINL, XPO1, SEC16A, CDH1, EGFR, TRIB2, WASF3LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KIAA1217_LPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KIAA1217_LPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLPPC3495559Juvenile arthritis1CTD_human