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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18670

FusionGeneSummary for KIAA1217_DNAJC17

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1217_DNAJC17
Fusion gene ID: 18670
HgeneTgene
Gene symbol

KIAA1217

DNAJC17

Gene ID

56243

55192

Gene nameKIAA1217DnaJ heat shock protein family (Hsp40) member C17
SynonymsETL4|SKT-
Cytomap

10p12.2-p12.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionsickle tail protein homologlikely orthologue of Mus musculus enhancer trap locus 4dnaJ homolog subfamily C member 17DnaJ (Hsp40) homolog, subfamily C, member 17
Modification date2018051920180519
UniProtAcc

Q5T5P2

Q9NVM6

Ensembl transtripts involved in fusion geneENST00000376462, ENST00000481700, 
ENST00000458595, ENST00000376454, 
ENST00000376452, ENST00000430453, 
ENST00000307544, ENST00000396446, 
ENST00000396445, ENST00000376451, 
ENST00000220496, ENST00000558727, 
Fusion gene scores* DoF score10 X 10 X 6=6002 X 2 X 2=8
# samples 112
** MAII scorelog2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: KIAA1217 [Title/Abstract] AND DNAJC17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF091043KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000376462ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376462ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000481700ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000481700ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000458595ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000458595ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376454ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376454ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376452ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376452ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000430453ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000430453ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000307544ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000307544ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000396446ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000396446ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000396445ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000396445ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376451ENST00000220496KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-
intron-intronENST00000376451ENST00000558727KIAA1217chr10

24824992

+DNAJC17chr15

41064303

-

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FusionProtFeatures for KIAA1217_DNAJC17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1217

Q5T5P2

DNAJC17

Q9NVM6

May negatively affect PAX8-induced thyroglobulin/TGtranscription. {ECO:0000250|UniProtKB:Q91WT4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1217_DNAJC17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1217_DNAJC17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1217_DNAJC17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1217_DNAJC17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource