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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18667

FusionGeneSummary for KIAA1211_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1211_SCFD2
Fusion gene ID: 18667
HgeneTgene
Gene symbol

KIAA1211

SCFD2

Gene ID

57482

152579

Gene nameKIAA1211sec1 family domain containing 2
Synonyms-STXBP1L1
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1211sec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018051920180519
UniProtAcc

Q6ZU35

Q8WU76

Ensembl transtripts involved in fusion geneENST00000264229, ENST00000541073, 
ENST00000504228, ENST00000505410, 
ENST00000401642, ENST00000388940, 
Fusion gene scores* DoF score6 X 4 X 4=9610 X 8 X 10=800
# samples 611
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1211 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-A5R7-01AKIAA1211chr4

57045596

+SCFD2chr4

53773758

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000264229ENST00000401642KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
5UTR-intronENST00000264229ENST00000388940KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-3CDSENST00000541073ENST00000401642KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-intronENST00000541073ENST00000388940KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-3CDSENST00000504228ENST00000401642KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-intronENST00000504228ENST00000388940KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-3CDSENST00000505410ENST00000401642KIAA1211chr4

57045596

+SCFD2chr4

53773758

-
intron-intronENST00000505410ENST00000388940KIAA1211chr4

57045596

+SCFD2chr4

53773758

-

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FusionProtFeatures for KIAA1211_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1211

Q6ZU35

SCFD2

Q8WU76

May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1211_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1211_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1211UBC, CAPZA2, NTRK1, FLNA, MYO19, MYO18A, GLI1SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1211_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1211_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource