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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18665

FusionGeneSummary for KIAA1211_NMU

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1211_NMU
Fusion gene ID: 18665
HgeneTgene
Gene symbol

KIAA1211

NMU

Gene ID

57482

10874

Gene nameKIAA1211neuromedin U
Synonyms--
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1211neuromedin-Uneuromedin U precursor-related peptide/neuromedin U preproproteinprepro-NMU
Modification date2018051920180523
UniProtAcc

Q6ZU35

P48645

Ensembl transtripts involved in fusion geneENST00000264229, ENST00000541073, 
ENST00000504228, ENST00000505410, 
ENST00000511469, ENST00000264218, 
ENST00000505262, ENST00000507338, 
ENST00000515325, 
Fusion gene scores* DoF score6 X 4 X 4=965 X 4 X 6=120
# samples 66
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1211 [Title/Abstract] AND NMU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNMU

GO:0007218

neuropeptide signaling pathway

10894543|11027493


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-06-2559-01AKIAA1211chr4

57045596

+NMUchr4

56496627

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000264229ENST00000511469KIAA1211chr4

57045596

+NMUchr4

56496627

-
5UTR-3CDSENST00000264229ENST00000264218KIAA1211chr4

57045596

+NMUchr4

56496627

-
5UTR-3CDSENST00000264229ENST00000505262KIAA1211chr4

57045596

+NMUchr4

56496627

-
5UTR-3CDSENST00000264229ENST00000507338KIAA1211chr4

57045596

+NMUchr4

56496627

-
5UTR-5UTRENST00000264229ENST00000515325KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000541073ENST00000511469KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000541073ENST00000264218KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000541073ENST00000505262KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000541073ENST00000507338KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-5UTRENST00000541073ENST00000515325KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000504228ENST00000511469KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000504228ENST00000264218KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000504228ENST00000505262KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000504228ENST00000507338KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-5UTRENST00000504228ENST00000515325KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000505410ENST00000511469KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000505410ENST00000264218KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000505410ENST00000505262KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-3CDSENST00000505410ENST00000507338KIAA1211chr4

57045596

+NMUchr4

56496627

-
intron-5UTRENST00000505410ENST00000515325KIAA1211chr4

57045596

+NMUchr4

56496627

-

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FusionProtFeatures for KIAA1211_NMU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1211

Q6ZU35

NMU

P48645

Stimulates muscle contractions of specific regions ofthe gastrointestinal tract. In humans, NmU stimulates contractionsof the ileum and urinary bladder.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1211_NMU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1211_NMU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1211UBC, CAPZA2, NTRK1, FLNA, MYO19, MYO18A, GLI1NMUNMUR2, NMUR1, SNTA1, KRTAP5-9, NOTCH2NL, HLA-DPA1, IL20RB, B3GALNT1, GINM1, TENC1, MANSC1, MGAT4C, PCDHA4, PCDH20, ENTPD7, F7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1211_NMU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1211_NMU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource