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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18664

FusionGeneSummary for KIAA1211_KIAA1211

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1211_KIAA1211
Fusion gene ID: 18664
HgeneTgene
Gene symbol

KIAA1211

KIAA1211

Gene ID

57482

57482

Gene nameKIAA1211KIAA1211
Synonyms--
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1211uncharacterized protein KIAA1211
Modification date2018051920180519
UniProtAcc

Q6ZU35

Q6ZU35

Ensembl transtripts involved in fusion geneENST00000264229, ENST00000541073, 
ENST00000504228, ENST00000505410, 
ENST00000264229, ENST00000541073, 
ENST00000504228, ENST00000505410, 
Fusion gene scores* DoF score6 X 4 X 4=966 X 4 X 4=96
# samples 66
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1211 [Title/Abstract] AND KIAA1211 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE892820KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000264229ENST00000264229KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000264229ENST00000541073KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000264229ENST00000504228KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-intronENST00000264229ENST00000505410KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000541073ENST00000264229KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000541073ENST00000541073KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000541073ENST00000504228KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-intronENST00000541073ENST00000505410KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000504228ENST00000264229KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000504228ENST00000541073KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000504228ENST00000504228KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-intronENST00000504228ENST00000505410KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000505410ENST00000264229KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000505410ENST00000541073KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-3CDSENST00000505410ENST00000504228KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+
intron-intronENST00000505410ENST00000505410KIAA1211chr4

57193809

-KIAA1211chr4

57193869

+

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FusionProtFeatures for KIAA1211_KIAA1211


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1211

Q6ZU35

KIAA1211

Q6ZU35


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1211_KIAA1211


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1211_KIAA1211


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1211_KIAA1211


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1211_KIAA1211


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource