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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1866

FusionGeneSummary for ANKRD50_ANKRD50

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD50_ANKRD50
Fusion gene ID: 1866
HgeneTgene
Gene symbol

ANKRD50

ANKRD50

Gene ID

57182

57182

Gene nameankyrin repeat domain 50ankyrin repeat domain 50
Synonyms--
Cytomap

4q28.1

4q28.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 50ankyrin repeat domain-containing protein 50
Modification date2018052220180522
UniProtAcc

Q9ULJ7

Q9ULJ7

Ensembl transtripts involved in fusion geneENST00000504087, ENST00000515641, 
ENST00000504087, ENST00000515641, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ANKRD50 [Title/Abstract] AND ANKRD50 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA336858ANKRD50chr4

125621279

+ANKRD50chr4

125620532

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504087ENST00000504087ANKRD50chr4

125621279

+ANKRD50chr4

125620532

+
intron-intronENST00000504087ENST00000515641ANKRD50chr4

125621279

+ANKRD50chr4

125620532

+
intron-intronENST00000515641ENST00000504087ANKRD50chr4

125621279

+ANKRD50chr4

125620532

+
intron-intronENST00000515641ENST00000515641ANKRD50chr4

125621279

+ANKRD50chr4

125620532

+

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FusionProtFeatures for ANKRD50_ANKRD50


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD50

Q9ULJ7

ANKRD50

Q9ULJ7

Involved in the endosome-to-plasma membrane traffickingand recycling of SNX27-retromer-dependent cargo proteins, such asGLUT1 (PubMed:25278552). Involved in the endosome-to-plasma membrane traffickingand recycling of SNX27-retromer-dependent cargo proteins, such asGLUT1 (PubMed:25278552).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD50_ANKRD50


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD50_ANKRD50


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD50_ANKRD50


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD50_ANKRD50


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource