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Fusion gene ID: 18651 |
FusionGeneSummary for KIAA1109_TMEM132D |
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Fusion gene information | Fusion gene name: KIAA1109_TMEM132D | Fusion gene ID: 18651 | Hgene | Tgene | Gene symbol | KIAA1109 | TMEM132D | Gene ID | 84162 | 121256 |
Gene name | KIAA1109 | transmembrane protein 132D | |
Synonyms | ALKKUCS|FSA|Tweek | MOLT|PPP1R153 | |
Cytomap | 4q27 | 12q24.33 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein KIAA1109fragile site-associated protein | transmembrane protein 132Dmature OL transmembrane proteinmature oligodendrocytes transmembrane proteinprotein phosphatase 1, regulatory subunit 153 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q2LD37 | Q14C87 | |
Ensembl transtripts involved in fusion gene | ENST00000264501, ENST00000455637, ENST00000388738, ENST00000495260, | ENST00000422113, ENST00000389441, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 5 X 4 X 4=80 |
# samples | 9 | 4 | |
** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KIAA1109 [Title/Abstract] AND TMEM132D [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TMEM132D | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF951394 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000264501 | ENST00000422113 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000264501 | ENST00000389441 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000455637 | ENST00000422113 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000455637 | ENST00000389441 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000388738 | ENST00000422113 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000388738 | ENST00000389441 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000495260 | ENST00000422113 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
intron-intron | ENST00000495260 | ENST00000389441 | KIAA1109 | chr4 | 123101194 | + | TMEM132D | chr12 | 130249107 | - |
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FusionProtFeatures for KIAA1109_TMEM132D |
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Hgene | Tgene |
KIAA1109 | TMEM132D |
May serve as a cell-surface marker for oligodendrocytedifferentiation. {ECO:0000269|PubMed:12966072}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIAA1109_TMEM132D |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIAA1109_TMEM132D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA1109_TMEM132D |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1109_TMEM132D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TMEM132D | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | TMEM132D | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | TMEM132D | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |