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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18647

FusionGeneSummary for KIAA1109_CHODL

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1109_CHODL
Fusion gene ID: 18647
HgeneTgene
Gene symbol

KIAA1109

CHODL

Gene ID

84162

140578

Gene nameKIAA1109chondrolectin
SynonymsALKKUCS|FSA|TweekC21orf68|MT75|PRED12
Cytomap

4q27

21q21.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1109fragile site-associated proteinchondrolectintransmembrane protein MT75
Modification date2018052320180523
UniProtAcc

Q2LD37

Q9H9P2

Ensembl transtripts involved in fusion geneENST00000264501, ENST00000455637, 
ENST00000388738, ENST00000495260, 
ENST00000400128, ENST00000400131, 
ENST00000400135, ENST00000400127, 
ENST00000338326, ENST00000299295, 
ENST00000543733, 
Fusion gene scores* DoF score7 X 6 X 6=2525 X 4 X 4=80
# samples 94
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1109 [Title/Abstract] AND CHODL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A2QH-01AKIAA1109chr4

123188113

+CHODLchr21

19613305

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264501ENST00000400128KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000400131KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000400135KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000400127KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000338326KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000299295KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000264501ENST00000543733KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000400128KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000400131KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000400135KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000400127KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000338326KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000299295KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000455637ENST00000543733KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000400128KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000400131KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000400135KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000400127KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000338326KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000299295KIAA1109chr4

123188113

+CHODLchr21

19613305

+
5CDS-intronENST00000388738ENST00000543733KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000400128KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000400131KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000400135KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000400127KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000338326KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000299295KIAA1109chr4

123188113

+CHODLchr21

19613305

+
intron-intronENST00000495260ENST00000543733KIAA1109chr4

123188113

+CHODLchr21

19613305

+

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FusionProtFeatures for KIAA1109_CHODL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1109

Q2LD37

CHODL

Q9H9P2

May play a role in the development of the nervous systemsuch as in neurite outgrowth and elongation. May be involved inmotor axon growth and guidance. {ECO:0000250|UniProtKB:Q568T5,ECO:0000250|UniProtKB:Q9CXM0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA1109_CHODL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1109_CHODL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1109BUB3, ZNF131CHODL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1109_CHODL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1109_CHODL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource