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Fusion gene ID: 18645 |
FusionGeneSummary for KIAA1109_ADAD1 |
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Fusion gene information | Fusion gene name: KIAA1109_ADAD1 | Fusion gene ID: 18645 | Hgene | Tgene | Gene symbol | KIAA1109 | ADAD1 | Gene ID | 84162 | 132612 |
Gene name | KIAA1109 | adenosine deaminase domain containing 1 | |
Synonyms | ALKKUCS|FSA|Tweek | Tenr | |
Cytomap | 4q27 | 4q27 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein KIAA1109fragile site-associated protein | adenosine deaminase domain-containing protein 1adenosine deaminase domain containing 1 (testis-specific)testis nuclear RNA-binding proteintestis tissue sperm-binding protein Li 92mP | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q2LD37 | Q96M93 | |
Ensembl transtripts involved in fusion gene | ENST00000264501, ENST00000455637, ENST00000388738, ENST00000495260, | ENST00000296513, ENST00000388724, ENST00000388725, ENST00000492454, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: KIAA1109 [Title/Abstract] AND ADAD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-VR-A8EU-01A | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000264501 | ENST00000296513 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-5UTR | ENST00000264501 | ENST00000388724 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000264501 | ENST00000388725 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000264501 | ENST00000492454 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-5UTR | ENST00000455637 | ENST00000296513 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-5UTR | ENST00000455637 | ENST00000388724 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000455637 | ENST00000388725 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000455637 | ENST00000492454 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-5UTR | ENST00000388738 | ENST00000296513 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-5UTR | ENST00000388738 | ENST00000388724 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000388738 | ENST00000388725 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
5CDS-intron | ENST00000388738 | ENST00000492454 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
3UTR-5UTR | ENST00000495260 | ENST00000296513 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
3UTR-5UTR | ENST00000495260 | ENST00000388724 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
3UTR-intron | ENST00000495260 | ENST00000388725 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
3UTR-intron | ENST00000495260 | ENST00000492454 | KIAA1109 | chr4 | 123118429 | + | ADAD1 | chr4 | 123301217 | + |
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FusionProtFeatures for KIAA1109_ADAD1 |
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Hgene | Tgene |
KIAA1109 | ADAD1 |
Plays a role in spermatogenesis. Binds to RNA but not toDNA (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIAA1109_ADAD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIAA1109_ADAD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KIAA1109 | BUB3, ZNF131 | ADAD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA1109_ADAD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1109_ADAD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |