![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 18635 |
FusionGeneSummary for KIAA0922_ZNF516 |
![]() |
Fusion gene information | Fusion gene name: KIAA0922_ZNF516 | Fusion gene ID: 18635 | Hgene | Tgene | Gene symbol | KIAA0922 | ZNF516 | Gene ID | 9658 |
Gene name | zinc finger protein 516 | ||
Synonyms | HsT287 | ||
Cytomap | 18q23 | ||
Type of gene | protein-coding | ||
Description | zinc finger protein 516 | ||
Modification date | 20180523 | ||
UniProtAcc | Q92618 | ||
Ensembl transtripts involved in fusion gene | ENST00000440693, ENST00000409663, ENST00000409959, | ENST00000443185, ENST00000524431, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: KIAA0922 [Title/Abstract] AND ZNF516 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV732097 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000440693 | ENST00000443185 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
intron-intron | ENST00000440693 | ENST00000524431 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
intron-intron | ENST00000409663 | ENST00000443185 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
intron-intron | ENST00000409663 | ENST00000524431 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
intron-intron | ENST00000409959 | ENST00000443185 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
intron-intron | ENST00000409959 | ENST00000524431 | KIAA0922 | chr4 | 154433563 | + | ZNF516 | chr18 | 74075162 | + |
Top |
FusionProtFeatures for KIAA0922_ZNF516 |
![]() |
Hgene | Tgene |
KIAA0922 | ZNF516 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Transcriptional regulator that binds to the promoter andactivates the transcription of genes promoting brown adiposetissue (BAT) differentiation. Among brown adipose tissue-specificgenes, binds the proximal region of the promoter of the UCP1 geneto activate its transcription and thereby regulate thermogenesis(By similarity). May also play a role in the cellular response toreplication stress (PubMed:23446422).{ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for KIAA0922_ZNF516 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for KIAA0922_ZNF516 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KIAA0922_ZNF516 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KIAA0922_ZNF516 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |