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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18635

FusionGeneSummary for KIAA0922_ZNF516

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0922_ZNF516
Fusion gene ID: 18635
HgeneTgene
Gene symbol

KIAA0922

ZNF516

Gene ID

9658

Gene namezinc finger protein 516
SynonymsHsT287
Cytomap

18q23

Type of geneprotein-coding
Descriptionzinc finger protein 516
Modification date20180523
UniProtAcc

Q92618

Ensembl transtripts involved in fusion geneENST00000440693, ENST00000409663, 
ENST00000409959, 
ENST00000443185, 
ENST00000524431, 
Fusion gene scores* DoF score5 X 5 X 5=1251 X 1 X 1=1
# samples 61
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: KIAA0922 [Title/Abstract] AND ZNF516 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV732097KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000440693ENST00000443185KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
intron-intronENST00000440693ENST00000524431KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
intron-intronENST00000409663ENST00000443185KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
intron-intronENST00000409663ENST00000524431KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
intron-intronENST00000409959ENST00000443185KIAA0922chr4

154433563

+ZNF516chr18

74075162

+
intron-intronENST00000409959ENST00000524431KIAA0922chr4

154433563

+ZNF516chr18

74075162

+

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FusionProtFeatures for KIAA0922_ZNF516


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0922

ZNF516

Q92618

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Transcriptional regulator that binds to the promoter andactivates the transcription of genes promoting brown adiposetissue (BAT) differentiation. Among brown adipose tissue-specificgenes, binds the proximal region of the promoter of the UCP1 geneto activate its transcription and thereby regulate thermogenesis(By similarity). May also play a role in the cellular response toreplication stress (PubMed:23446422).{ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0922_ZNF516


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0922_ZNF516


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0922_ZNF516


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0922_ZNF516


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource