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Fusion gene ID: 18632 |
FusionGeneSummary for KIAA0922_LRAT |
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Fusion gene information | Fusion gene name: KIAA0922_LRAT | Fusion gene ID: 18632 | Hgene | Tgene | Gene symbol | KIAA0922 | LRAT | Gene ID | 9227 |
Gene name | lecithin retinol acyltransferase | ||
Synonyms | LCA14 | ||
Cytomap | 4q32.1 | ||
Type of gene | protein-coding | ||
Description | lecithin retinol acyltransferaselecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | ||
Modification date | 20180519 | ||
UniProtAcc | O95237 | ||
Ensembl transtripts involved in fusion gene | ENST00000440693, ENST00000409663, ENST00000409959, | ENST00000500890, ENST00000507827, ENST00000336356, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 2 X 3=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KIAA0922 [Title/Abstract] AND LRAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LRAT | GO:0042572 | retinol metabolic process | 10819989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-H8-A6C1-01A | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000440693 | ENST00000500890 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000440693 | ENST00000507827 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000440693 | ENST00000336356 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409663 | ENST00000500890 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409663 | ENST00000507827 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409663 | ENST00000336356 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409959 | ENST00000500890 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409959 | ENST00000507827 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
5CDS-intron | ENST00000409959 | ENST00000336356 | KIAA0922 | chr4 | 154395040 | + | LRAT | chr4 | 155649855 | + |
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FusionProtFeatures for KIAA0922_LRAT |
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Hgene | Tgene |
KIAA0922 | LRAT |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Transfers the acyl group from the sn-1 position ofphosphatidylcholine to all-trans retinol, producing all-transretinyl esters. Retinyl esters are storage forms of vitamin A.LRAT plays a critical role in vision. It provides the all-transretinyl ester substrates for the isomerohydrolase which processesthe esters into 11-cis-retinol in the retinal pigment epithelium;due to a membrane-associated alcohol dehydrogenase, 11 cis-retinolis oxidized and converted into 11-cis-retinaldehyde which is thechromophore for rhodopsin and the cone photopigments.{ECO:0000269|PubMed:9920938}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIAA0922_LRAT |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIAA0922_LRAT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KIAA0922 | FBXO6, HLA-DRA, ATP1B3, MCOLN3, CGRRF1, BTNL8, CHRNA9, KIF11, PTAR1, FAM46A, NLGN3 | LRAT | LRAT, NME2P1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA0922_LRAT |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LRAT | O95237 | DB00162 | Vitamin A | Lecithin retinol acyltransferase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for KIAA0922_LRAT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LRAT | C0917796 | Optic Atrophy, Hereditary, Leber | 2 | CTD_human |
Tgene | LRAT | C0015398 | Eye Diseases, Hereditary | 1 | CTD_human |
Tgene | LRAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | LRAT | C0042842 | Vitamin A Deficiency | 1 | CTD_human |
Tgene | LRAT | C0339527 | Leber Congenital Amaurosis | 1 | CTD_human;ORPHANET |
Tgene | LRAT | C2750063 | Leber Congenital Amaurosis 14 | 1 | CTD_human;UNIPROT |
Tgene | LRAT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |