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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18600

FusionGeneSummary for KIAA0368_WNK2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0368_WNK2
Fusion gene ID: 18600
HgeneTgene
Gene symbol

KIAA0368

WNK2

Gene ID

65268

Gene nameWNK lysine deficient protein kinase 2
SynonymsNY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43
Cytomap

9q22.31

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43
Modification date20180523
UniProtAcc

Q9Y3S1

Ensembl transtripts involved in fusion geneENST00000338205, ENST00000259335, 
ENST00000374378, ENST00000465499, 
ENST00000427277, ENST00000297954, 
ENST00000395475, ENST00000356055, 
ENST00000349097, ENST00000395477, 
ENST00000471076, 
Fusion gene scores* DoF score6 X 7 X 4=1687 X 7 X 7=343
# samples 77
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/343*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0368 [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWNK2

GO:0006468

protein phosphorylation

21733846

TgeneWNK2

GO:0046777

protein autophosphorylation

17667937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A06Y-01AKIAA0368chr9

114246396

-WNK2chr9

95991978

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000338205ENST00000427277KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-5UTRENST00000338205ENST00000297954KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-5UTRENST00000338205ENST00000395475KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-5UTRENST00000338205ENST00000356055KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-5UTRENST00000338205ENST00000349097KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-5UTRENST00000338205ENST00000395477KIAA0368chr9

114246396

-WNK2chr9

95991978

+
5CDS-intronENST00000338205ENST00000471076KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000427277KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000297954KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000395475KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000356055KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000349097KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000259335ENST00000395477KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-intronENST00000259335ENST00000471076KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000427277KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000297954KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000395475KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000356055KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000349097KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000374378ENST00000395477KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-intronENST00000374378ENST00000471076KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000427277KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000297954KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000395475KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000356055KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000349097KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-5UTRENST00000465499ENST00000395477KIAA0368chr9

114246396

-WNK2chr9

95991978

+
intron-intronENST00000465499ENST00000471076KIAA0368chr9

114246396

-WNK2chr9

95991978

+

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FusionProtFeatures for KIAA0368_WNK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0368

WNK2

Q9Y3S1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival, and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SLC12A2, SCNN1A,SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulatesthe EGF-induced activation of the ERK/MAPK-pathway and thedownstream cell cycle progression. Affects MAPK3/MAPK1 activity bymodulating the activity of MAP2K1 and this modulation depends onphosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering withthe activity of PAK1 by controlling the balance of the activity ofupstream regulators of PAK1 activity, RHOA and RAC1, which displayreciprocal activity. {ECO:0000269|PubMed:17667937,ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0368_WNK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0368_WNK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA0368PCM1, ARF6, PTP4A3, HNRNPA1, CLN3, SIRT7, CCDC57, PCYT1B, FBXO2, GOLGB1, SPECC1L, KIF5B, MYH7, MYH10, SYNE1, ANK2, DST, CKS1B, CPD, DNAJB9, RNF168, HNRNPM, CEP170B, ANKRD17, GAREML, MKI67, MYO10, RABEP1, RAB11FIP4, UIMC1, SF3B2, UBE2G2, UBE2Q1, VPS11, ZNF483, PSMC4, PSMD4, TUBA1A, TUBB4B, TUBB, MYO1B, KIF1B, HSPA1A, VPS36, VPS26A, TMED4, RNF217, MARCH5, KDM2B, KDM2A, FBXO44, CEP152, RCN2, PSMC2, PSMD1, PSMC6, DCTN1, DYNC1I1, PSMA6, FLOT1, FLOT2, PSMA2, SPTAN1, FN1, ADRB2, LATS2, MOB4, PSMC5, PSMD11, PSMD12, PSMD13, PSMD14, PSMD3, PSMD8, RPS23, RPS26, TSR1, TXNL1, UBR4, UCHL5, WDR26, SHFM1, AGTRAP, CMTM5, EGFR, BSG, SPACA1, GNAI2, LYPD3, RP2, HSPB1, CDKN2AIP, DDX1, DNAJB1, DNAJB4, EIF4H, FARSA, HNRNPH1, BAG1, C14orf166, CCT4, EEF1A1, EIF4E, KDM3A, LDHB, NHP2L1, PSMA5, RABIF, RAD23B, RTCB, SMCHD1, TATDN1, XPO1, MAN2B1, TIMM8B, NTRK1, ATP1A1, SLC1A5, USP9X, NOP14, SH3PXD2A, ICE1, HNRNPD, TSNAX, SLC33A1, SGTB, TMEM132A, THOC2, HIGD1A, SPICE1, PLBD2, FOXB1, FOXL1, NANOG, POU5F1, NPY2R, SLC39A9, IL13RA2, C5orf28, SLC18A1, CHRM4, APLNR, OPRM1, SLC10A7, EDNRB, TMEM199, HTR2C, MAS1, SLC2A5, EDEM3, BRCA1WNK2YWHAZ, WNK1, SGK1, ATXN1, KLHL3, KLHL2, DGCR14, TSC22D4, PSMC3, SPATA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0368_WNK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0368_WNK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource