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Fusion gene ID: 18590 |
FusionGeneSummary for KIAA0319L_UBA6 |
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Fusion gene information | Fusion gene name: KIAA0319L_UBA6 | Fusion gene ID: 18590 | Hgene | Tgene | Gene symbol | KIAA0319L | UBA6 | Gene ID | 79932 | 55236 |
Gene name | KIAA0319 like | ubiquitin like modifier activating enzyme 6 | |
Synonyms | AAVR|AAVRL | E1-L2|MOP-4|UBE1L2 | |
Cytomap | 1p34.3 | 4q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dyslexia-associated protein KIAA0319-like proteinAAV receptorAAV receptor likeadeno-associated virus receptorpolycystic kidney disease 1-related | ubiquitin-like modifier-activating enzyme 6UBA6, ubiquitin-activating enzyme E1monocyte protein 4ubiquitin-activating enzyme 6ubiquitin-activating enzyme E1-like 2ubiquitin-activating enzyme E1-like protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IZA0 | A0AVT1 | |
Ensembl transtripts involved in fusion gene | ENST00000325722, ENST00000373266, ENST00000485551, | ENST00000322244, ENST00000420827, | |
Fusion gene scores | * DoF score | 14 X 8 X 10=1120 | 3 X 3 X 2=18 |
# samples | 14 | 3 | |
** MAII score | log2(14/1120*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KIAA0319L [Title/Abstract] AND UBA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRP | TCGA-J7-8537-01A | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000325722 | ENST00000322244 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
Frame-shift | ENST00000325722 | ENST00000420827 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
intron-3CDS | ENST00000373266 | ENST00000322244 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
intron-3CDS | ENST00000373266 | ENST00000420827 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
intron-3CDS | ENST00000485551 | ENST00000322244 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
intron-3CDS | ENST00000485551 | ENST00000420827 | KIAA0319L | chr1 | 35972213 | - | UBA6 | chr4 | 68534392 | - |
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FusionProtFeatures for KIAA0319L_UBA6 |
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Hgene | Tgene |
KIAA0319L | UBA6 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KIAA0319L_UBA6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KIAA0319L_UBA6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KIAA0319L | SIAH1, LGALS3, CEACAM21, LGALS8, LGALS9, FCN1, GINM1, MMP3, PILRA, TMEM17, TMEM216, CD4, CCDC40, TMEM30B, MGAT4C, LACRT, LMAN2L, TMPRSS3, LRRTM1, ST8SIA4, PCDHB7, HLA-DRB1, SERPINA12 | UBA6 | UBE2D2, ELAVL1, AIPL1, UBC, UBD, UBE2Z, UCHL3, TSN, HDLBP, NPEPPS, USP48, VPS26B, UBE4B, SMAD9, CTPS1, FKBP9, H2AFV, HEXA, LIMD1, NOL3, OGFOD1, OXSR1, PDCD6IP, PGGT1B, TWF2, AHCYL1, EHD1, GNPDA1, NUBP2, PYGB, RAD23A, RAD23B, TRNT1, XPNPEP1, UBE2S, UBE2D1, UBE2D3, UBE2T, UBE2L3, UBE2G2, HMBOX1, CCDC8, UBE2L6, MBD5, SERPINB5, FYTTD1, OR5F1, ARHGAP25, ATG7, C1orf123, CLUH, DIAPH1, DYNLT1, ENOPH1, IMPDH2, MTRR, NUP188, NUP93, PFKP, SMS, SNF8, STRAP, NTRK1, FMR1, FXR1, EIF4A3, ITCH, LINC01587, CAPN6, PLEKHO1, ALDH3B1, RAB2B, SNRNP27, GTF2E2, MYLIP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KIAA0319L_UBA6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA0319L_UBA6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |