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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18573

FusionGeneSummary for KIAA0232_SLC12A8

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0232_SLC12A8
Fusion gene ID: 18573
HgeneTgene
Gene symbol

KIAA0232

SLC12A8

Gene ID

9778

84561

Gene nameKIAA0232solute carrier family 12 member 8
Synonyms-CCC9
Cytomap

4p16.1

3q21.2

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA0232solute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8
Modification date2018051920180523
UniProtAcc

Q92628

A0AV02

Ensembl transtripts involved in fusion geneENST00000503278, ENST00000425103, 
ENST00000307659, 		ENST00000393469, 
ENST00000423114, ENST00000469902, 
ENST00000314584, ENST00000430155, 
ENST00000465475, 
Fusion gene scores* DoF score8 X 7 X 4=2247 X 8 X 6=336
# samples 811
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0232 [Title/Abstract] AND SLC12A8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF095281KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000503278ENST00000393469KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
intron-intronENST00000503278ENST00000423114KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
intron-intronENST00000503278ENST00000469902KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
intron-intronENST00000503278ENST00000314584KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
intron-intronENST00000503278ENST00000430155KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
intron-intronENST00000503278ENST00000465475KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000393469KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000423114KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000469902KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000314584KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000430155KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000425103ENST00000465475KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000393469KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000423114KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000469902KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000314584KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000430155KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+
3UTR-intronENST00000307659ENST00000465475KIAA0232chr4

6884360

-SLC12A8chr3

124852206

+

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FusionProtFeatures for KIAA0232_SLC12A8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0232

Q92628

SLC12A8

A0AV02


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0232_SLC12A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0232_SLC12A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0232_SLC12A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0232_SLC12A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource