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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18569

FusionGeneSummary for KIAA0232_KIAA0232

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0232_KIAA0232
Fusion gene ID: 18569
HgeneTgene
Gene symbol

KIAA0232

KIAA0232

Gene ID

9778

9778

Gene nameKIAA0232KIAA0232
Synonyms--
Cytomap

4p16.1

4p16.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA0232uncharacterized protein KIAA0232
Modification date2018051920180519
UniProtAcc

Q92628

Q92628

Ensembl transtripts involved in fusion geneENST00000503278, ENST00000425103, 
ENST00000307659, 
ENST00000503278, 
ENST00000425103, ENST00000307659, 
Fusion gene scores* DoF score8 X 7 X 4=2243 X 3 X 2=18
# samples 83
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA0232 [Title/Abstract] AND KIAA0232 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA313447KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000503278ENST00000503278KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
intron-3UTRENST00000503278ENST00000425103KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
intron-3UTRENST00000503278ENST00000307659KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-intronENST00000425103ENST00000503278KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-3UTRENST00000425103ENST00000425103KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-3UTRENST00000425103ENST00000307659KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-intronENST00000307659ENST00000503278KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-3UTRENST00000307659ENST00000425103KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+
3UTR-3UTRENST00000307659ENST00000307659KIAA0232chr4

6884755

-KIAA0232chr4

6884691

+

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FusionProtFeatures for KIAA0232_KIAA0232


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0232

Q92628

KIAA0232

Q92628


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KIAA0232_KIAA0232


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA0232_KIAA0232


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA0232_KIAA0232


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA0232_KIAA0232


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource