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Fusion gene ID: 18546 |
FusionGeneSummary for KHSRP_TFE3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KHSRP_TFE3 | Fusion gene ID: 18546 | Hgene | Tgene | Gene symbol | KHSRP | TFE3 | Gene ID | 8570 | 7030 |
| Gene name | KH-type splicing regulatory protein | transcription factor binding to IGHM enhancer 3 | |
| Synonyms | FBP2|FUBP2|KSRP | RCCP2|RCCX1|TFEA|bHLHe33 | |
| Cytomap | 19p13.3 | Xp11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | far upstream element-binding protein 2FUSE-binding protein 2p75 | transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q92945 | P19532 | |
| Ensembl transtripts involved in fusion gene | ENST00000398148, | ENST00000315869, ENST00000487451, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 10 X 9 X 4=360 |
| # samples | 7 | 19 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/360*10)=-0.921997487998727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KHSRP [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KHSRP | GO:0043488 | regulation of mRNA stability | 16126846 |
| Hgene | KHSRP | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 16126846 |
| Hgene | KHSRP | GO:0061014 | positive regulation of mRNA catabolic process | 16126846 |
| Hgene | KHSRP | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 16126846 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-CJ-5681-01A | KHSRP | chr19 | 6415150 | - | TFE3 | chrX | 48895857 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000398148 | ENST00000315869 | KHSRP | chr19 | 6415150 | - | TFE3 | chrX | 48895857 | - |
| 5CDS-5UTR | ENST00000398148 | ENST00000487451 | KHSRP | chr19 | 6415150 | - | TFE3 | chrX | 48895857 | - |
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FusionProtFeatures for KHSRP_TFE3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KHSRP | TFE3 |
| Binds to the dendritic targeting element and may play arole in mRNA trafficking (By similarity). Part of a ternarycomplex that binds to the downstream control sequence (DCS) of thepre-mRNA. Mediates exon inclusion in transcripts that are subjectto tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activategene expression. Also involved in degradation of inherentlyunstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644,ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. | Transcription factor that specifically recognizes andbinds E-box sequences (5'-CANNTG-3'). Efficient DNA-bindingrequires dimerization with itself or with another MiT/TFE familymember such as TFEB or MITF. In association with TFEB, activatesthe expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells andthymus-dependent humoral immunity. Specifically recognizes theMUE3 box, a subset of E-boxes, present in the immunoglobulinenhancer. It also binds very well to a USF/MLTF site. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 498_612 | 709 | 712 | Compositional bias | Note=Ala/Gly/Pro-rich |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 68_496 | 709 | 712 | Compositional bias | Note=Gly-rich |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 7_67 | 709 | 712 | Compositional bias | Note=Gly/Pro-rich |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 144_208 | 709 | 712 | Domain | KH 1 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 233_299 | 709 | 712 | Domain | KH 2 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 322_386 | 709 | 712 | Domain | KH 3 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 424_491 | 709 | 712 | Domain | KH 4 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 571_684 | 709 | 712 | Region | Note=4 X 12 AA imperfect repeats |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 571_582 | 709 | 712 | Repeat | Note=1 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 617_628 | 709 | 712 | Repeat | Note=2 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 643_654 | 709 | 712 | Repeat | Note=3 |
| Hgene | KHSRP | chr19:6415150 | chrX:48895857 | ENST00000398148 | - | 19 | 20 | 673_684 | 709 | 712 | Repeat | Note=4 |
| Tgene | >TFE3 | chr19:6415150 | chrX:48895857 | ENST00000315869 | - | 0 | 10 | 346_399 | -87 | 576 | Domain | bHLH |
| Tgene | >TFE3 | chr19:6415150 | chrX:48895857 | ENST00000315869 | - | 0 | 10 | 260_271 | -87 | 576 | Region | Strong transcription activation domain |
| Tgene | >TFE3 | chr19:6415150 | chrX:48895857 | ENST00000315869 | - | 0 | 10 | 409_430 | -87 | 576 | Region | Note=Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KHSRP_TFE3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KHSRP_ENST00000398148_chr19_6415150_-_TFE3_ENST00000315869_chrX_48895857_-_709aa MSDYSTGGPPPGPPPPAGGGGGAGGAGGGPPPGPPGAGDRGGGGPGGGGPGGGSAGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGG DAATTVNNSTPDFGFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQI SPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILI QDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQ DDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAI NQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPH QYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KHSRP_ENST00000398148_chr19_6415150_-_TFE3_ENST00000315869_chrX_48895857_-_2127nt ATGTCGGACTACAGCACGGGAGGACCCCCGCCCGGGCCGCCGCCGCCCGCCGGCGGGGGCGGGGGAGCCGGAGGCGCCGGGGGAGGCCCT CCGCCGGGCCCGCCAGGCGCGGGGGACCGGGGCGGCGGCGGTCCCGGCGGCGGCGGCCCGGGCGGGGGGTCGGCCGGGGGCCCCTCTCAG CCACCCGGCGGAGGCGGCCCGGGAATCCGCAAGGACGCTTTCGCCGACGCCGTGCAGCGGGCCCGCCAGATTGCAGCCAAAATTGGAGGC GATGCTGCCACGACAGTGAATAACAGCACTCCTGATTTTGGTTTTGGGGGCCAAAAGAGACAGTTGGAAGATGGAGATCAACCGGAGAGC AAGAAGCTGGCTTCCCAGGGAGACTCAATCAGTTCTCAACTTGGACCCATCCATCCTCCCCCAAGGACTTCAATGACAGAAGAGTACAGG GTCCCAGACGGCATGGTGGGCCTGATCATTGGCAGAGGAGGTGAACAAATTAACAAAATCCAACAGGATTCAGGCTGCAAAGTACAGATT TCTCCAGACAGCGGTGGCCTACCCGAGCGCAGTGTGTCCTTGACAGGAGCCCCAGAATCTGTCCAGAAAGCCAAGATGATGCTGGATGAC ATTGTGTCTCGGGGTCGTGGGGGCCCCCCAGGACAGTTCCACGACAACGCCAACGGGGGCCAGAACGGCACCGTGCAGGAGATCATGATC CCCGCGGGCAAGGCCGGCCTGGTCATTGGCAAGGGCGGGGAGACCATTAAGCAGCTGCAGGAACGCGCTGGAGTGAAGATGATCTTAATT CAGGACGGATCTCAGAATACGAATGTGGACAAACCTCTCCGCATCATTGGGGATCCTTACAAAGTGCAGCAAGCCTGTGAGATGGTGATG GACATCCTCCGGGAACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGCGGAGGCATCGATGTGCCAGTGCCC AGGCATTCTGTTGGCGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCTGGCGTGCGGATACAGTTCAAGCAA GATGACGGGACAGGGCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCAGCCCGGATCATCAACGACCTCCTC CAGAGCCTCAGGAGTGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGCCGAGGAAGAGGCCAAGGCAATTGG GGTCCCCCTGGCGGGGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGAGGTGGCGAGAATGTGAAAGCCATA AACCAGCAGACGGGAGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTCAAGTTGTTCATCATCCGGGGTTCA CCCCAGCAGATTGACCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTTGGACCAGGCCCAGGTGGCCCAGGC CCTGCTGGCCCAATGGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCACATGCCGGGGGGCCCCCTCCTCAC CAGTACCCACCCCAGGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCAAGCAAAGCAGCTGCAGCGGCCGCG GACCCCAACGCCGCGTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCCGGCCCCGCACCGGCCCCTGCGGCC CCACCGGCTCAGGGTGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGGGAAGAGTATTACAAAAAGATCGGC CAGCAGCCCCAGCAGCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTACAAGAAGCAAGCGCAAGTGGCCACC GGAGGGGGTCCAGGAGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTACAGACAGCAGGCCGCTTACTACGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KHSRP_ENST00000398148_chr19_6415150_-_TFE3_ENST00000315869_chrX_48895857_-_3094nt TGTGGAGCGAGGCCTTGTTCCCGCGTTGAGCCGCCGCCGCCGCCGCCGCCTCCTCAGCTTCAGCCTCCGCGCCAGGCCCGGCCCCGCCGC GCCATGTCGGACTACAGCACGGGAGGACCCCCGCCCGGGCCGCCGCCGCCCGCCGGCGGGGGCGGGGGAGCCGGAGGCGCCGGGGGAGGC CCTCCGCCGGGCCCGCCAGGCGCGGGGGACCGGGGCGGCGGCGGTCCCGGCGGCGGCGGCCCGGGCGGGGGGTCGGCCGGGGGCCCCTCT CAGCCACCCGGCGGAGGCGGCCCGGGAATCCGCAAGGACGCTTTCGCCGACGCCGTGCAGCGGGCCCGCCAGATTGCAGCCAAAATTGGA GGCGATGCTGCCACGACAGTGAATAACAGCACTCCTGATTTTGGTTTTGGGGGCCAAAAGAGACAGTTGGAAGATGGAGATCAACCGGAG AGCAAGAAGCTGGCTTCCCAGGGAGACTCAATCAGTTCTCAACTTGGACCCATCCATCCTCCCCCAAGGACTTCAATGACAGAAGAGTAC AGGGTCCCAGACGGCATGGTGGGCCTGATCATTGGCAGAGGAGGTGAACAAATTAACAAAATCCAACAGGATTCAGGCTGCAAAGTACAG ATTTCTCCAGACAGCGGTGGCCTACCCGAGCGCAGTGTGTCCTTGACAGGAGCCCCAGAATCTGTCCAGAAAGCCAAGATGATGCTGGAT GACATTGTGTCTCGGGGTCGTGGGGGCCCCCCAGGACAGTTCCACGACAACGCCAACGGGGGCCAGAACGGCACCGTGCAGGAGATCATG ATCCCCGCGGGCAAGGCCGGCCTGGTCATTGGCAAGGGCGGGGAGACCATTAAGCAGCTGCAGGAACGCGCTGGAGTGAAGATGATCTTA ATTCAGGACGGATCTCAGAATACGAATGTGGACAAACCTCTCCGCATCATTGGGGATCCTTACAAAGTGCAGCAAGCCTGTGAGATGGTG ATGGACATCCTCCGGGAACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGCGGAGGCATCGATGTGCCAGTG CCCAGGCATTCTGTTGGCGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCTGGCGTGCGGATACAGTTCAAG CAAGATGACGGGACAGGGCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCAGCCCGGATCATCAACGACCTC CTCCAGAGCCTCAGGAGTGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGCCGAGGAAGAGGCCAAGGCAAT TGGGGTCCCCCTGGCGGGGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGAGGTGGCGAGAATGTGAAAGCC ATAAACCAGCAGACGGGAGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTCAAGTTGTTCATCATCCGGGGT TCACCCCAGCAGATTGACCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTTGGACCAGGCCCAGGTGGCCCA GGCCCTGCTGGCCCAATGGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCACATGCCGGGGGGCCCCCTCCT CACCAGTACCCACCCCAGGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCAAGCAAAGCAGCTGCAGCGGCC GCGGACCCCAACGCCGCGTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCCGGCCCCGCACCGGCCCCTGCG GCCCCACCGGCTCAGGGTGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGGGAAGAGTATTACAAAAAGATC GGCCAGCAGCCCCAGCAGCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTACAAGAAGCAAGCGCAAGTGGCC ACCGGAGGGGGTCCAGGAGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTACAGACAGCAGGCCGCTTACTAC GGACAGACCCCAGGTCCTGGCGGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAGGTGCAGACCCATCTGGAGAACCCAACGCGC TACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCA CCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATG GCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAA ATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGT CAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCA AAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAA CTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAG CTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAG GACCAAATTGATATTGCAGAGGTTGAGCAGTATGGACCACAAGAAAACGTTCACATGTTTGTAGATTCTGATTCAACTTATTGCTCCAGT |
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FusionGenePPI for KHSRP_TFE3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KHSRP | PUF60, EXOSC2, PARN, PTBP2, HNRNPA1, HNRNPH1, A1CF, PSMA3, GSK3B, STK3, GADD45A, ELAVL1, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RAE1, CPLX1, CIRBP, ASF1B, STRIP1, FN1, VCAM1, UBL4A, ITGA4, MPG, CD81, TARDBP, APBB1, GARS, GFPT1, HNRNPD, ALDH16A1, NAP1L4, WWOX, LGR4, UBC, STAU1, HUWE1, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, MAEL, CHCHD2, CPSF6, CPSF7, FUBP3, HTRA2, EIF4B, RAD54L2, SMARCA2, KYNU, NUP50, PRDX2, PRDX5, SIN3A, SMARCC1, SMARCC2, SYMPK, NTRK1, SCARNA22, MKNK2, FOS, JUN, FOXF1, CRY2, MCM2, NANOG, U2AF2, KLHL12, BRCA1, UBE2I, DROSHA, DGCR8, MIRLET7A1, MIRLET7A3 | TFE3 | AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KHSRP_TFE3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KHSRP | Q92945 | DB11638 | Artenimol | Far upstream element-binding protein 2 | small molecule | approved|investigational |
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RelatedDiseases for KHSRP_TFE3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KHSRP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
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