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Fusion gene ID: 18540 |
FusionGeneSummary for KHNYN_SEC13 |
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Fusion gene information | Fusion gene name: KHNYN_SEC13 | Fusion gene ID: 18540 | Hgene | Tgene | Gene symbol | KHNYN | SEC13 | Gene ID | 23351 | 6396 |
Gene name | KH and NYN domain containing | SEC13 homolog, nuclear pore and COPII coat complex component | |
Synonyms | KIAA0323 | D3S1231E|SEC13L1|SEC13R|npp-20 | |
Cytomap | 14q12 | 3p25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein KHNYN | protein SEC13 homologGATOR complex protein SEC13SEC13 homolog, nuclear pore and COPII coating complex componentSEC13-like 1 isoformSEC13-like protein 1SEC13-related protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O15037 | P55735 | |
Ensembl transtripts involved in fusion gene | ENST00000251343, ENST00000556842, ENST00000553935, ENST00000554268, | ENST00000397109, ENST00000337354, ENST00000350697, ENST00000397117, ENST00000383801, ENST00000492602, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 5 X 4=160 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/160*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KHNYN [Title/Abstract] AND SEC13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SEC13 | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE161424 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000251343 | ENST00000397109 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
3UTR-3CDS | ENST00000251343 | ENST00000337354 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
3UTR-3CDS | ENST00000251343 | ENST00000350697 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
3UTR-3CDS | ENST00000251343 | ENST00000397117 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
3UTR-3CDS | ENST00000251343 | ENST00000383801 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
3UTR-intron | ENST00000251343 | ENST00000492602 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000556842 | ENST00000397109 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000556842 | ENST00000337354 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000556842 | ENST00000350697 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000556842 | ENST00000397117 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000556842 | ENST00000383801 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-intron | ENST00000556842 | ENST00000492602 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000553935 | ENST00000397109 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000553935 | ENST00000337354 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000553935 | ENST00000350697 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000553935 | ENST00000397117 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000553935 | ENST00000383801 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-intron | ENST00000553935 | ENST00000492602 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000554268 | ENST00000397109 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000554268 | ENST00000337354 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000554268 | ENST00000350697 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000554268 | ENST00000397117 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-3CDS | ENST00000554268 | ENST00000383801 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
intron-intron | ENST00000554268 | ENST00000492602 | KHNYN | chr14 | 24908767 | - | SEC13 | chr3 | 10353671 | - |
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FusionProtFeatures for KHNYN_SEC13 |
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Hgene | Tgene |
KHNYN | SEC13 |
Functions as a component of the nuclear pore complex(NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 isinvolved in the biogenesis of COPII-coated vesicles.{ECO:0000269|PubMed:8972206}. As a component of the GATOR subcomplex GATOR2, functionswithin the amino acid-sensing branch of the TORC1 signalingpathway. Indirectly activates mTORC1 and the TORC1 signalingpathway through the inhibition of the GATOR1 subcomplex(PubMed:23723238). It is negatively regulated by the upstreamamino acid sensors SESN2 and CASTOR1 (PubMed:25457612,PubMed:27487210). {ECO:0000269|PubMed:23723238,ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KHNYN_SEC13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KHNYN_SEC13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KHNYN_SEC13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KHNYN_SEC13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |