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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 18532

FusionGeneSummary for KHDRBS1_SERINC2

check button Fusion gene summary
Fusion gene informationFusion gene name: KHDRBS1_SERINC2
Fusion gene ID: 18532
HgeneTgene
Gene symbol

KHDRBS1

SERINC2

Gene ID

10657

347735

Gene nameKH RNA binding domain containing, signal transduction associated 1serine incorporator 2
SynonymsSam68|p62|p68FKSG84|PRO0899|TDE2|TDE2L
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associaserine incorporator 2tumor differentially expressed protein 2
Modification date2018052220180523
UniProtAcc

Q07666

Q96SA4

Ensembl transtripts involved in fusion geneENST00000327300, ENST00000307714, 
ENST00000492989, 		ENST00000373710, 
ENST00000536859, ENST00000373709, 
ENST00000536384, ENST00000491976, 
Fusion gene scores* DoF score4 X 4 X 4=6410 X 4 X 9=360
# samples 410
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KHDRBS1 [Title/Abstract] AND SERINC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

HgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

HgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

HgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532

HgeneKHDRBS1

GO:0051259

protein complex oligomerization

10332027|10749975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EO-A3KW-01AKHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000327300ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
5CDS-3UTRENST00000327300ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3UTRENST00000307714ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3UTRENST00000492989ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+

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FusionProtFeatures for KHDRBS1_SERINC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KHDRBS1

Q07666

SERINC2

Q96SA4

Recruited and tyrosine phosphorylated by severalreceptor systems, for example the T-cell, leptin and insulinreceptors. Once phosphorylated, functions as an adapter protein insignal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle.Represses CBP-dependent transcriptional activation apparently bycompeting with other nuclear factors for binding to CBP. Also actsas a putative regulator of mRNA stability and/or translation ratesand mediates mRNA nuclear export. Positively regulates theassociation of constitutive transport element (CTE)-containingmRNA with large polyribosomes and translation initiation.According to some authors, is not involved in thenucleocytoplasmic export of unspliced (CTE)-containing RNA speciesaccording to (PubMed:22253824). RNA-binding protein that plays arole in the regulation of alternative splicing and influences mRNAsplice site selection and exon inclusion. Binds to RNA containing5'-[AU]UAA-3' as a bipartite motif spaced by more than 15nucleotides. Binds poly(A). Can regulate CD44 alternative splicingin a Ras pathway-dependent manner (By similarity). In cooperationwith HNRNPA1 modulates alternative splicing of BCL2L1 by promotingsplicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836,PubMed:20186123). Can regulate alternative splicing of NRXN1 andNRXN3 in the laminin G-like domain 6 containing the evolutionaryconserved neurexin alternative spliced segment 4 (AS4) involved inneurexin selective targeting to postsynaptic partners. In aneuronal activity-dependent manner cooperates synergistically withKHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. Thecooperation with KHDRBS2/SLIM-1 is antagonistic for regulation ofNXRN3 alternative splicing at AS4 (By similarity).{ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911,ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123,ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824,ECO:0000269|PubMed:26758068}. Isoform 3, which is expressed in growth-arrested cellsonly, inhibits S phase. {ECO:0000269|PubMed:9013542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3934_41208444Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3944_55208444Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3959_89208444Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39171_197208444DomainKH
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010131_15013456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010160_18213456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010202_22413456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010239_25613456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010268_29013456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010317_33913456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010385_40713456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+01040_5713456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+010422_44413456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+01096_11813456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111131_15022465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111160_18222465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111202_22422465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111239_25622465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111268_29022465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111317_33922465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111385_40722465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+11140_5722465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+111422_44422465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+11196_11822465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010131_15017460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010160_18217460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010202_22417460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010239_25617460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010268_29017460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010317_33917460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010385_40717460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+01040_5717460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+010422_44417460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+01096_11817460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010131_15017460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010160_18217460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010202_22417460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010239_25617460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010268_29017460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010317_33917460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010385_40717460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+01040_5717460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+010422_44417460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+01096_11817460TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39282_292208444Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39295_301208444Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39302_332208444Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39334_363208444Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18282_2920405Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18295_3010405Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18302_3320405Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18334_3630405Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1834_410405Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1844_550405Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1859_890405Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18171_1970405DomainKH
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39100_260208444RegionInvolved in homodimerization
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18100_2600405RegionInvolved in homodimerization
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709+0105_2713456TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710+1115_2722465TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384+0105_2717460TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859+0105_2717460TransmembraneHelical


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FusionGeneSequence for KHDRBS1_SERINC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373710_chr1_31896540_+_651aa
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQ
GNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEG
AGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVV
GSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAV
LPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHR
QVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536859_chr1_31896540_+_651aa
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQ
GNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEG
AGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVV
GSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAV
LPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHR
QVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373709_chr1_31896540_+_651aa
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQ
GNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEG
AGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVV
GSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAV
LPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHR
QVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536384_chr1_31896540_+_651aa
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQ
GNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEG
AGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVV
GSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAV
LPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHR
QVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373710_chr1_31896540_+_1953nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCT
CATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAA
GGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCC
TGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTC
CTCTTCCTGGGGGTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGG
GCCGGGATCCCCACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCG
GCCTTCTTCTTCTTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTT
AAGTTCCTGATCCTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTG
GGCTCCTTCCTCTTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAG
TGCGATTCCCGTGCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATG
TACTACACTGAGCCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTC
CTGCCCAAGGTCCAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCC
CTATCCAGTATCCCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAG
ACCCAGTGGTGGGATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGG
CAGGTGAACAGCCTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGG
GCCTTTGACAACGAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACG
CTCACCAACTGGTACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536859_chr1_31896540_+_1953nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCT
CATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAA
GGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCC
TGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTC
CTCTTCCTGGGGGTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGG
GCCGGGATCCCCACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCG
GCCTTCTTCTTCTTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTT
AAGTTCCTGATCCTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTG
GGCTCCTTCCTCTTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAG
TGCGATTCCCGTGCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATG
TACTACACTGAGCCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTC
CTGCCCAAGGTCCAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCC
CTATCCAGTATCCCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAG
ACCCAGTGGTGGGATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGG
CAGGTGAACAGCCTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGG
GCCTTTGACAACGAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACG
CTCACCAACTGGTACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373709_chr1_31896540_+_1953nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCT
CATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAA
GGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCC
TGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTC
CTCTTCCTGGGGGTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGG
GCCGGGATCCCCACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCG
GCCTTCTTCTTCTTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTT
AAGTTCCTGATCCTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTG
GGCTCCTTCCTCTTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAG
TGCGATTCCCGTGCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATG
TACTACACTGAGCCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTC
CTGCCCAAGGTCCAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCC
CTATCCAGTATCCCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAG
ACCCAGTGGTGGGATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGG
CAGGTGAACAGCCTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGG
GCCTTTGACAACGAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACG
CTCACCAACTGGTACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536384_chr1_31896540_+_1953nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCT
CATAAGAACATGAAACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAA
GGGAATACAATCAAAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCC
TGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTC
CTCTTCCTGGGGGTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGG
GCCGGGATCCCCACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCG
GCCTTCTTCTTCTTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTT
AAGTTCCTGATCCTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTG
GGCTCCTTCCTCTTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAG
TGCGATTCCCGTGCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATG
TACTACACTGAGCCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTC
CTGCCCAAGGTCCAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCC
CTATCCAGTATCCCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAG
ACCCAGTGGTGGGATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGG
CAGGTGAACAGCCTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGG
GCCTTTGACAACGAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACG
CTCACCAACTGGTACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373710_chr1_31896540_+_2598nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536859_chr1_31896540_+_2511nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000373709_chr1_31896540_+_2599nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG

>In-frame_KHDRBS1_ENST00000327300_chr1_32497241_+_SERINC2_ENST00000536384_chr1_31896540_+_2595nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG


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FusionGenePPI for KHDRBS1_SERINC2


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KHDRBS1RAPSN, CREBBP, PRMT1, EMG1, SRC, STUB1, TUBB3, GRB2, GRAP2, PLCG1, FYN, BTK, PIK3R1, IRS1, INSR, RASA1, CRK, NCK1, STAT3, YTHDC1, NCF1, KHDRBS1, PTK6, DHX9, ITK, WBP4, FNBP4, HNRNPK, LCK, KHDRBS2, PACSIN1, PACSIN2, PACSIN3, SMARCA2, SRRM1, SH3GL1, RIPK1, FADD, CASP8, SMARCAD1, LYN, YES1, ITSN2, HCK, NPHP1, SNX9, OSTF1, SH3KBP1, ABI2, AHI1, AMPH, ARHGEF9, ARHGEF4, PPP1R13B, BAIAP2L1, PSTPIP1, CD2AP, DLG1, DLG2, DLG3, DLG4, DOCK2, DOCK3, FGR, SH3PXD2A, FRK, BZRAP1, ITSN1, MIA2, MPP6, MYO1C, MYO7A, NCK2, SORBS1, RUSC2, SASH1, SH3YL1, SKAP2, SNX30, SPATA13, NCKIPSD, UBASH3B, DNMBP, VAV1, ZDHHC6, TJP1, CUL3, CAND1, HNRNPR, HNRNPC, ESR1, U2AF2, RALY, RBM7, DDX5, CIRBP, PTBP2, KHDRBS3, RBFOX2, SMAD2, CBX6, TNFRSF1A, CD81, CSK, AGO1, CREB3L3, PIK3R3, RBMX, CRKL, EFEMP1, SCG5, SSFA2, TBL1X, GPHN, POT1, AZIN1, ACTB, APBB1, GAS7, RPA1, RPA2, RPA3, LGR4, DROSHA, ZBTB7A, CUL7, OBSL1, CCDC8, EZH2, SUZ12, RNF2, BMI1, FBXW11, NTRK1, ATXN2, ATXN2L, COPA, DDX17, DHX15, GLRX3, SFPQ, SRSF3, NCSTN, RBM15, SYNCRIP, USO1, WBP11, BANP, HDAC6, EWSR1, SRPK2, CLK1, HIST1H3E, HNRNPA1, PPP1CB, MATR3, MPHOSPH8, CRY1, CRY2, SNW1, CDC5L, UBC, TRIM25, BRCA1SERINC2ATP6V0A2, ATP6V0A1, GHITM, ATP6V0D1, STOM, TMBIM6, LGALS3, GPR89B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39351_443208444HNRNPA1
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18351_4430405HNRNPA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KHDRBS1_SERINC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KHDRBS1_SERINC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSERINC2C0001973Alcoholic Intoxication, Chronic1PSYGENET