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Fusion gene ID: 18517 |
FusionGeneSummary for KDM6A_YEATS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM6A_YEATS4 | Fusion gene ID: 18517 | Hgene | Tgene | Gene symbol | KDM6A | YEATS4 | Gene ID | 7403 | 8089 |
| Gene name | lysine demethylase 6A | YEATS domain containing 4 | |
| Synonyms | KABUK2|UTX|bA386N14.2 | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | |
| Cytomap | Xp11.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 6AbA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))histone demethylase UTXlysine (K)-specific demethylase 6Aubiquitously transcribed tetratricopeptide repeat protein X-linkedubiquito | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O15550 | O95619 | |
| Ensembl transtripts involved in fusion gene | ENST00000377967, ENST00000382899, ENST00000536777, ENST00000543216, ENST00000479423, | ENST00000247843, ENST00000548020, | |
| Fusion gene scores | * DoF score | 13 X 7 X 9=819 | 8 X 3 X 4=96 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/819*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KDM6A [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| Tgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0901-01B | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377967 | ENST00000247843 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000377967 | ENST00000548020 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000382899 | ENST00000247843 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000382899 | ENST00000548020 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000536777 | ENST00000247843 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000536777 | ENST00000548020 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000543216 | ENST00000247843 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| In-frame | ENST00000543216 | ENST00000548020 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| intron-3CDS | ENST00000479423 | ENST00000247843 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
| intron-3CDS | ENST00000479423 | ENST00000548020 | KDM6A | chrX | 44920664 | + | YEATS4 | chr12 | 69783927 | + |
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FusionProtFeatures for KDM6A_YEATS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM6A | YEATS4 |
| Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code(PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylatestrimethylated and dimethylated but not monomethylated H3 'Lys-27'(PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays acentral role in regulation of posterior development, by regulatingHOX gene expression (PubMed:17851529). Demethylation of 'Lys-27'of histone H3 is concomitant with methylation of 'Lys-4' ofhistone H3, and regulates the recruitment of the PRC1 complex andmonoubiquitination of histone H2A (PubMed:17761849). Plays ademethylase-independent role in chromatin remodeling to regulateT-box family member-dependent gene expression (By similarity).{ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478,ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529,ECO:0000269|PubMed:18003914}. | Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 9_17 | 475 | 1402 | Compositional bias | Note=Poly-Ala |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 130_163 | 475 | 1402 | Repeat | Note=TPR 2 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 170_199 | 475 | 1402 | Repeat | Note=TPR 3 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 205_238 | 475 | 1402 | Repeat | Note=TPR 4 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 250_283 | 475 | 1402 | Repeat | Note=TPR 5 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 284_317 | 475 | 1402 | Repeat | Note=TPR 6 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 318_351 | 475 | 1402 | Repeat | Note=TPR 7 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 352_385 | 475 | 1402 | Repeat | Note=TPR 8 |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 93_126 | 475 | 1402 | Repeat | Note=TPR 1 |
| Tgene | >YEATS4 | chrX:44920664 | chr12:69783927 | ENST00000247843 | + | 5 | 7 | 178_226 | 171 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 1095_1258 | 475 | 1402 | Domain | JmjC |
| Tgene | YEATS4 | chrX:44920664 | chr12:69783927 | ENST00000247843 | + | 5 | 7 | 22_126 | 171 | 228 | Domain | YEATS |
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FusionGeneSequence for KDM6A_YEATS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_531aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWS >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_531aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWS >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_538aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQACKPHHPNTEPVLGLSQTPISQQSLPLHMIPSSQVDDLSSPAKRKRTSSPTK >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_538aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQACKPHHPNTEPVLGLSQTPISQQSLPLHMIPSSQVDDLSSPAKRKRTSSPTK >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_486aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQLQSLKXKPEKNXKLLRKKQA >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_486aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQLQSLKXKPEKNXKLLRKKQA >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_486aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQLQSLKXKPEKNXKLLRKKQA >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_486aa MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAI QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQLQSLKXKPEKNXKLLRKKQA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1595nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGGCTCAGTTGTGTAACCTTCCACAAGGTAGTCTACAGAATAAAACTAAATTACTTCCTAGTATTGAG GAGGCGTGGAGCCTACCAATTCCCGCAGAGCTTACCTCCAGGCAGGGTGCCATGAACACAGCACAGCAGAATACTTCTGACAATTGGAGT GGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAG TGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAA >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1595nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGGCTCAGTTGTGTAACCTTCCACAAGGTAGTCTACAGAATAAAACTAAATTACTTCCTAGTATTGAG GAGGCGTGGAGCCTACCAATTCCCGCAGAGCTTACCTCCAGGCAGGGTGCCATGAACACAGCACAGCAGAATACTTCTGACAATTGGAGT GGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAG TGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAA >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1616nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGGCATGTAAACCTCATCATCCAAATACTGAACCTGTATTAGGCCTCAGTCAAACACCAATTTCACAG CAATCCTTGCCACTACACATGATTCCTTCTAGCCAAGTAGATGACCTGTCCAGTCCTGCCAAGAGGAAAAGAACATCTAGTCCAACAAAG AATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAA TTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGA >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1616nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGGCATGTAAACCTCATCATCCAAATACTGAACCTGTATTAGGCCTCAGTCAAACACCAATTTCACAG CAATCCTTGCCACTACACATGATTCCTTCTAGCCAAGTAGATGACCTGTCCAGTCCTGCCAAGAGGAAAAGAACATCTAGTCCAACAAAG AATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAA TTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGA >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1460nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1460nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1460nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1460nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_2116nt GGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCG CTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGG AGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTG TTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGG AAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTG GTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCA AGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACT GTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAG CTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAG ATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCT GGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAA GTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAAT TGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAA ATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGGCTCAGTTGTGTAACCTTCCACAAG GTAGTCTACAGAATAAAACTAAATTACTTCCTAGTATTGAGGAGGCGTGGAGCCTACCAATTCCCGCAGAGCTTACCTCCAGGCAGGGTG CCATGAACACAGCACAGCAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCAT GGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGA GATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCA AGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTG CAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATC TTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTT TTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTT GTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTGTAT >In-frame_KDM6A_ENST00000377967_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1951nt GGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCG CTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGG AGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTG TTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGG AAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTG GTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCA AGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACT GTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAG CTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAG ATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCT GGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAA GTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAAT TGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAA ATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGGCTCAGTTGTGTAACCTTCCACAAG GTAGTCTACAGAATAAAACTAAATTACTTCCTAGTATTGAGGAGGCGTGGAGCCTACCAATTCCCGCAGAGCTTACCTCCAGGCAGGGTG CCATGAACACAGCACAGCAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCAT GGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGA GATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCA AGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTG CAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATC TTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTT >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_2113nt GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATG CATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGC TTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATG CTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAG AGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCA AGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATT CAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAG GTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCT GGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTA GTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGGCATGTAAACCTCATCATCCAAATACTGAACCTGTATTAGGCCTCAGTC AAACACCAATTTCACAGCAATCCTTGCCACTACACATGATTCCTTCTAGCCAAGTAGATGACCTGTCCAGTCCTGCCAAGAGGAAAAGAA CATCTAGTCCAACAAAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGT GTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGAT TGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGC AAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAA ATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTT AATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTA AAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTTGTA CTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTGTATATG >In-frame_KDM6A_ENST00000382899_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1948nt GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATG CATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGC TTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATG CTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAG AGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCA AGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATT CAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAG GTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCT GGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTA GTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGGCATGTAAACCTCATCATCCAAATACTGAACCTGTATTAGGCCTCAGTC AAACACCAATTTCACAGCAATCCTTGCCACTACACATGATTCCTTCTAGCCAAGTAGATGACCTGTCCAGTCCTGCCAAGAGGAAAAGAA CATCTAGTCCAACAAAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCATTCATGGT GTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGAT TGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGC AAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAA ATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTT AATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTA >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1957nt GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATG CATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGC TTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATG CTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAG AGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCA AGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATT CAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAG GTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCT GGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTA GTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAG TACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGC TAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAG AAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTC ACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGA ATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATT CTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAA AGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACC >In-frame_KDM6A_ENST00000536777_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1792nt GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATG CATTTCAGTGGGCAATTAAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGC TTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATG CTGAAATTCAATTTCACATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAG AGAATCTTTCTGCACAAGTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCA AGGAAAGCTATGCTATTCAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATT CAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAG GTGTGCTATATCAGCAGCAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCT GGATGGACCTAGGCACTCTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTA GTAATACCTCTGCACTTGCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAG TACAGCAACAAGCTCATTCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGC TAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAG AAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTC ACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGA ATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATT >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000247843_chr12_69783927_+_1940nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG ACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTT ACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGC AATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACA GTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAA TTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTT >In-frame_KDM6A_ENST00000543216_chrX_44920664_+_YEATS4_ENST00000548020_chr12_69783927_+_1775nt ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC AGTTTACAGTCTGACTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTATAATGCATTTCAGTGGGCAATT AAAGCATTTCAGGAGGTGCTTTATGTTGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAAC ACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAATTTCAC ATTGCCCACTTATATGAAACCCAGAGGAAATATCATTCTGCAAAAGAAGCTTATGAACAACTTTTGCAGACAGAGAATCTTTCTGCACAA GTAAAAGCAACTGTCTTACAACAGTTAGGTTGGATGCATCACACTGTAGATCTCCTGGGAGATAAAGCCACCAAGGAAAGCTATGCTATT CAGTATCTCCAAAAGTCCTTGGAAGCAGATCCTAATTCTGGCCAGTCCTGGTATTTCCTCGGAAGGTGCTATTCAAGTATTGGGAAAGTT CAGGATGCCTTTATATCTTACAGGCAGTCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTATATCAGCAG CAAAATCAGCCCATGGATGCTTTACAGGCCTATATTTGTGCTGTACAATTGGACCATGGCCATGCTGCAGCCTGGATGGACCTAGGCACT CTCTATGAATCCTGCAACCAGCCTCAGGATGCCATTAAATGCTACTTAAATGCAACTAGAAGCAAAAGTTGTAGTAATACCTCTGCACTT GCAGCACGAATTAAGTATTTACAGAATACTTCTGACAATTGGAGTGGTGGACATGCTGTGTCACATCCTCCAGTACAGCAACAAGCTCAT TCATGGTGTTTGACACCACAGAAATTACAGTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCT TTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATG ACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTT ACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGC AATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACA |
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FusionGenePPI for KDM6A_YEATS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KDM6A | TLE1, KMT2D, KMT2C, NCOA6, N4BP2, PAXIP1, PPP6R3, ZNF281, PROSER1, ASH2L, RBBP5, WDR5, HIST3H3, WDR82, HIST1H3A, SRF, TBX5, NKX2-5, GATA4, SMARCA4, HIST2H3C, SMAD9, TP53, MAFA, MAFB, RNF2, ATM, MSH6, FNTA, PTEN, EYA2, ARHGAP22, FOXA1 | YEATS4 | TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | YEATS4 | chrX:44920664 | chr12:69783927 | ENST00000247843 | + | 5 | 7 | 168_227 | 171 | 228 | TACC1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | KDM6A | chrX:44920664 | chr12:69783927 | ENST00000377967 | + | 14 | 29 | 1_1095 | 475 | 1402 | SUPT6H |
| Tgene | YEATS4 | chrX:44920664 | chr12:69783927 | ENST00000247843 | + | 5 | 7 | 163_227 | 171 | 228 | MLLT10 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KDM6A_YEATS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KDM6A_YEATS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KDM6A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | KDM6A | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | KDM6A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | KDM6A | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |
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