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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 18512

FusionGeneSummary for KDM6A_NDUFB11

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM6A_NDUFB11
Fusion gene ID: 18512
HgeneTgene
Gene symbol

KDM6A

NDUFB11

Gene ID

7403

54539

Gene namelysine demethylase 6ANADH:ubiquinone oxidoreductase subunit B11
SynonymsKABUK2|UTX|bA386N14.2CI-ESSS|ESSS|NP17.3|Np15|P17.3
Cytomap

Xp11.3

Xp11.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 6AbA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))histone demethylase UTXlysine (K)-specific demethylase 6Aubiquitously transcribed tetratricopeptide repeat protein X-linkedubiquitoNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDaNADH-ubiquinone oxidoreductase ESSS subunitcomplex I NP17.3 subunitcomplex I-ESSSneuronal protein 17.3
Modification date2018052320180522
UniProtAcc

O15550

Q9NX14

Ensembl transtripts involved in fusion geneENST00000377967, ENST00000382899, 
ENST00000536777, ENST00000543216, 
ENST00000479423, 
ENST00000377811, 
ENST00000276062, 
Fusion gene scores* DoF score13 X 7 X 9=8192 X 2 X 2=8
# samples 122
** MAII scorelog2(12/819*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: KDM6A [Title/Abstract] AND NDUFB11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A2QJ-01AKDM6AchrX

44733233

+NDUFB11chrX

47002143

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377967ENST00000377811KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000377967ENST00000276062KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000382899ENST00000377811KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000382899ENST00000276062KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000536777ENST00000377811KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000536777ENST00000276062KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000543216ENST00000377811KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
In-frameENST00000543216ENST00000276062KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
intron-3CDSENST00000479423ENST00000377811KDM6AchrX

44733233

+NDUFB11chrX

47002143

-
intron-3CDSENST00000479423ENST00000276062KDM6AchrX

44733233

+NDUFB11chrX

47002143

-

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FusionProtFeatures for KDM6A_NDUFB11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM6A

O15550

NDUFB11

Q9NX14

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code(PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylatestrimethylated and dimethylated but not monomethylated H3 'Lys-27'(PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays acentral role in regulation of posterior development, by regulatingHOX gene expression (PubMed:17851529). Demethylation of 'Lys-27'of histone H3 is concomitant with methylation of 'Lys-4' ofhistone H3, and regulates the recruitment of the PRC1 complex andmonoubiquitination of histone H2A (PubMed:17761849). Plays ademethylase-independent role in chromatin remodeling to regulateT-box family member-dependent gene expression (By similarity).{ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478,ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529,ECO:0000269|PubMed:18003914}. Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+2299_17751402Compositional biasNote=Poly-Ala
TgeneNDUFB11chrX:44733233chrX:47002143ENST00000276062-0389_10969164TransmembraneHelical
TgeneNDUFB11chrX:44733233chrX:47002143ENST00000377811-0389_10969154TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+2291095_1258751402DomainJmjC
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229130_163751402RepeatNote=TPR 2
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229170_199751402RepeatNote=TPR 3
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229205_238751402RepeatNote=TPR 4
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229250_283751402RepeatNote=TPR 5
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229284_317751402RepeatNote=TPR 6
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229318_351751402RepeatNote=TPR 7
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+229352_385751402RepeatNote=TPR 8
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+22993_126751402RepeatNote=TPR 1


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FusionGeneSequence for KDM6A_NDUFB11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_160aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_170aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_160aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_170aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_160aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_170aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_160aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_170aa
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKNPDSHGYDKDPVLDV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_480nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATG
AAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCC

>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_510nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGC
ACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTT

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_480nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATG
AAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCC

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_510nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGC
ACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTT

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_480nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATG
AAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCC

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_510nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGC
ACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTT

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_480nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATG
AAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCC

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_510nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGC
ACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_622nt
GGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCG
CTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGG
AGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACC
CAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCC
TTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGG
CCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGGCT

>In-frame_KDM6A_ENST00000377967_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_648nt
GGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCG
CTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGG
AGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACC
CAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCC
TTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGCACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCG
AAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAG
AGGATGAGTGACCAGTTGCTAAGTGGGGCTCAAGAAGCACCGCCTTCCCCACCCCCTGCCTGCCATTCTGACCTCTTCTCAGAGCACCTA

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_598nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGG
ACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATC
TGCCTGACTACAGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAAT
CCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGGCTCAAGAAGCACCGCCTTCCCCACCC

>In-frame_KDM6A_ENST00000382899_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_624nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGG
ACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATC
TGCCTGACTACAGGTGCACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACC
GAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGT

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_598nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGG
ACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATC
TGCCTGACTACAGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAAT
CCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGGCTCAAGAAGCACCGCCTTCCCCACCC

>In-frame_KDM6A_ENST00000536777_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_624nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGG
ACCCCGTTTTGGACGTCTGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATC
TGCCTGACTACAGGTGCACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACC
GAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGT

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000377811_chrX_47002143_-_581nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGATG
AAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTTCCCATCATGGAATCCAACTGCTTCGACCCC
AGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGGCTCAAGAAGCACCGCCTTCCCCACCCCCTGCCTGCCATTCTGA

>In-frame_KDM6A_ENST00000543216_chrX_44733233_+_NDUFB11_ENST00000276062_chrX_47002143_-_607nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGAACCCAGACTCCCATGGTTATGACAAGGACCCCGTTTTGGACGTC
TGGAACATGCGACTTGTCTTCTTCTTTGGCGTCTCCATCATCCTGGTCCTTGGCAGCACCTTTGTGGCCTATCTGCCTGACTACAGGTGC
ACAGGGTGTCCAAGAGCGTGGGATGGGATGAAAGAGTGGTCCCGCCGCGAAGCTGAGAGGCTTGTGAAATACCGAGAGGCCAATGGCCTT
CCCATCATGGAATCCAACTGCTTCGACCCCAGCAAGATCCAGCTGCCAGAGGATGAGTGACCAGTTGCTAAGTGGGGCTCAAGAAGCACC


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FusionGenePPI for KDM6A_NDUFB11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM6ATLE1, KMT2D, KMT2C, NCOA6, N4BP2, PAXIP1, PPP6R3, ZNF281, PROSER1, ASH2L, RBBP5, WDR5, HIST3H3, WDR82, HIST1H3A, SRF, TBX5, NKX2-5, GATA4, SMARCA4, HIST2H3C, SMAD9, TP53, MAFA, MAFB, RNF2, ATM, MSH6, FNTA, PTEN, EYA2, ARHGAP22, FOXA1NDUFB11BAG6, PPBP, NDUFA2, NDUFB8, NDUFB10, UQCRB, CYSTM1, LAMTOR3, SURF4, NDUFAF3, TMX1, TXNDC5, ABCB10, SDHB, ABCD3, EIF4A1, FATE1, ECSIT, NDUFA12, NDUFS3, NDUFS5, NDUFA9, NDUFA11, NDUFAF1, RAB5C, VAPA, SUCO, NDUFA4, APOOL, NDUFB7, NDUFV3, NDUFB6, NDUFS4, NDUFA7, NDUFB5, NDUFB9, ND5, NDUFB3, NDUFC2, DNAJC30, NDUFV2, NDUFS8, NDUFV1, NDUFS6, ND4, NDUFS1, NDUFA10, NDUFA3, NDUFB1, NDUFB4, ACAD9, ND1, NDUFS7, NDUFA6, NDUFS2, TMEM126B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM6AchrX:44733233chrX:47002143ENST00000377967+2291_1095751402SUPT6H


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM6A_NDUFB11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KDM6A_NDUFB11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM6AC0005695Bladder Neoplasm1CTD_human
HgeneKDM6AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKDM6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKDM6AC0279626Squamous cell carcinoma of esophagus1CTD_human