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Fusion gene ID: 1851 |
FusionGeneSummary for ANKRD37_MTERFD2 |
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Fusion gene information | Fusion gene name: ANKRD37_MTERFD2 | Fusion gene ID: 1851 | Hgene | Tgene | Gene symbol | ANKRD37 | MTERFD2 | Gene ID | 353322 | 130916 |
Gene name | ankyrin repeat domain 37 | mitochondrial transcription termination factor 4 | |
Synonyms | Lrp2bp | MTERFD2 | |
Cytomap | 4q35.1 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ankyrin repeat domain-containing protein 37low density lipoprotein receptor-related protein binding proteinlow-density lipoprotein receptor-related protein 2-binding protein | transcription termination factor 4, mitochondrialMTERF domain-containing protein 2 | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q7Z713 | ||
Ensembl transtripts involved in fusion gene | ENST00000507479, ENST00000335174, | ENST00000464344, ENST00000495694, ENST00000391980, ENST00000406593, ENST00000407095, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ANKRD37 [Title/Abstract] AND MTERFD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-G9-6499-01A | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000507479 | ENST00000464344 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
intron-intron | ENST00000507479 | ENST00000495694 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
intron-intron | ENST00000507479 | ENST00000391980 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
intron-intron | ENST00000507479 | ENST00000406593 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
intron-intron | ENST00000507479 | ENST00000407095 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
5CDS-intron | ENST00000335174 | ENST00000464344 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
5CDS-intron | ENST00000335174 | ENST00000495694 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
5CDS-intron | ENST00000335174 | ENST00000391980 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
5CDS-intron | ENST00000335174 | ENST00000406593 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
5CDS-intron | ENST00000335174 | ENST00000407095 | ANKRD37 | chr4 | 186321395 | + | MTERFD2 | chr2 | 242036128 | - |
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FusionProtFeatures for ANKRD37_MTERFD2 |
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Hgene | Tgene |
ANKRD37 | MTERFD2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANKRD37_MTERFD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANKRD37_MTERFD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANKRD37 | MTERFD2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANKRD37_MTERFD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD37_MTERFD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |