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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1850

FusionGeneSummary for ANKRD37_MRPL49

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD37_MRPL49
Fusion gene ID: 1850
HgeneTgene
Gene symbol

ANKRD37

MRPL49

Gene ID

353322

740

Gene nameankyrin repeat domain 37mitochondrial ribosomal protein L49
SynonymsLrp2bpC11orf4|L49mt|MRP-L49|NOF|NOF1
Cytomap

4q35.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 37low density lipoprotein receptor-related protein binding proteinlow-density lipoprotein receptor-related protein 2-binding protein39S ribosomal protein L49, mitochondrialmitochondrial large ribosomal subunit protein mL49neighbor of FAUnext to FAU
Modification date2018032920180523
UniProtAcc

Q7Z713

Q13405

Ensembl transtripts involved in fusion geneENST00000507479, ENST00000335174, 
ENST00000524482, ENST00000534078, 
ENST00000526171, ENST00000279242, 
ENST00000531705, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD37 [Title/Abstract] AND MRPL49 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM552612ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000507479ENST00000524482ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000507479ENST00000534078ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000507479ENST00000526171ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-3UTRENST00000507479ENST00000279242ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000507479ENST00000531705ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-3UTRENST00000335174ENST00000524482ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000335174ENST00000534078ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000335174ENST00000526171ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-3UTRENST00000335174ENST00000279242ANKRD37chr4

186319406

-MRPL49chr11

64893817

+
intron-intronENST00000335174ENST00000531705ANKRD37chr4

186319406

-MRPL49chr11

64893817

+

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FusionProtFeatures for ANKRD37_MRPL49


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD37

Q7Z713

MRPL49

Q13405


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD37_MRPL49


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD37_MRPL49


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD37_MRPL49


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD37_MRPL49


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMRPL49C0025202melanoma1CTD_human