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Fusion gene ID: 18453 |
FusionGeneSummary for KDM4B_CHAF1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM4B_CHAF1A | Fusion gene ID: 18453 | Hgene | Tgene | Gene symbol | KDM4B | CHAF1A | Gene ID | 23030 | 10036 |
| Gene name | lysine demethylase 4B | chromatin assembly factor 1 subunit A | |
| Synonyms | JMJD2B|TDRD14B | CAF-1|CAF1|CAF1B|CAF1P150|P150 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14B | chromatin assembly factor 1 subunit ACAF-1 subunit ACAF-I 150 kDa subunitCAF-I p150CTB-50L17.7chromatin assembly factor I (150 kDa)chromatin assembly factor I p150 subunithp150 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | O94953 | Q13111 | |
| Ensembl transtripts involved in fusion gene | ENST00000159111, ENST00000381759, ENST00000536461, ENST00000592175, | ENST00000301280, ENST00000587368, | |
| Fusion gene scores | * DoF score | 19 X 9 X 12=2052 | 1 X 1 X 1=1 |
| # samples | 19 | 1 | |
| ** MAII score | log2(19/2052*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KDM4B [Title/Abstract] AND CHAF1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM4B | GO:0033169 | histone H3-K9 demethylation | 21914792 |
| Hgene | KDM4B | GO:0070544 | histone H3-K36 demethylation | 21914792 |
| Tgene | CHAF1A | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | CHAF1A | GO:0031497 | chromatin assembly | 8858152 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DU-8163-01A | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000159111 | ENST00000301280 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| 5CDS-intron | ENST00000159111 | ENST00000587368 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| In-frame | ENST00000381759 | ENST00000301280 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| 5CDS-intron | ENST00000381759 | ENST00000587368 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| In-frame | ENST00000536461 | ENST00000301280 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| 5CDS-intron | ENST00000536461 | ENST00000587368 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| intron-3CDS | ENST00000592175 | ENST00000301280 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
| intron-intron | ENST00000592175 | ENST00000587368 | KDM4B | chr19 | 5082515 | + | CHAF1A | chr19 | 4418017 | + |
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FusionProtFeatures for KDM4B_CHAF1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM4B | CHAF1A |
| Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does notdemethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', witha weaker activity than KDM4A, KDM4C and KDM4D. Demethylation ofLys residue generates formaldehyde and succinate.{ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. | Core component of the CAF-1 complex, a complex thoughtto mediate chromatin assembly in DNA replication and DNA repair.Assembles histone octamers onto replicating DNA in vitro. CAF-1performs the first step of the nucleosome assembly process,bringing newly synthesized histones H3 and H4 to replicating DNA;histones H2A/H2B can bind to this chromatin precursor subsequentto DNA replication to complete the histone octamer. CHAF1A bindsto histones H3 and H4. It may play a role in heterochromatinmaintenance in proliferating cells by bringing newly synthesizedcbx proteins to heterochromatic DNA replication foci (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:15327775}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 146_309 | 306 | 1097 | Domain | JmjC |
| Hgene | KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 15_57 | 306 | 1097 | Domain | JmjN |
| Hgene | KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 146_309 | 306 | 449 | Domain | JmjC |
| Hgene | KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 15_57 | 306 | 449 | Domain | JmjN |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 323_453 | 320 | 957 | Compositional bias | Note=Arg/Glu/Lys-rich |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 602_608 | 320 | 957 | Compositional bias | Note=Poly-Glu |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 619_623 | 320 | 957 | Compositional bias | Note=Poly-Asp |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 905_911 | 320 | 957 | Compositional bias | Note=Poly-Glu |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 642_678 | 320 | 957 | Region | Note=Necessary for homodimerization and competence for chromatin assembly |
| Tgene | >CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 660_956 | 320 | 957 | Region | Note=Binds to p60 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 463_535 | 306 | 1097 | Compositional bias | Note=Pro-rich |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 463_535 | 306 | 449 | Compositional bias | Note=Pro-rich |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 917_974 | 306 | 1097 | Domain | Note=Tudor 1 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 975_1031 | 306 | 1097 | Domain | Note=Tudor 2 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 917_974 | 306 | 449 | Domain | Note=Tudor 1 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 975_1031 | 306 | 449 | Domain | Note=Tudor 2 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 731_789 | 306 | 1097 | Zinc finger | Note=PHD-type 1 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 794_827 | 306 | 1097 | Zinc finger | C2HC pre-PHD-type |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000159111 | + | 9 | 23 | 850_907 | 306 | 1097 | Zinc finger | PHD-type 2 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 731_789 | 306 | 449 | Zinc finger | Note=PHD-type 1 |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 794_827 | 306 | 449 | Zinc finger | C2HC pre-PHD-type |
| Hgene | >KDM4B | chr19:5082515 | chr19:4418017 | ENST00000381759 | + | 9 | 12 | 850_907 | 306 | 449 | Zinc finger | PHD-type 2 |
| Tgene | CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 233_246 | 320 | 957 | Motif | Note=PxVxL motif |
| Tgene | CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 1_314 | 320 | 957 | Region | Note=Binds to CBX1 chromo shadow domain |
| Tgene | CHAF1A | chr19:5082515 | chr19:4418017 | ENST00000301280 | + | 2 | 15 | 1_49 | 320 | 957 | Region | Note=Binds to PCNA |
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FusionGeneSequence for KDM4B_CHAF1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KDM4B_ENST00000159111_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_943aa MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC >In-frame_KDM4B_ENST00000381759_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_943aa MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC >In-frame_KDM4B_ENST00000536461_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_943aa MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KDM4B_ENST00000159111_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_2829nt ATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAA TACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTAT GATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAG AAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGC AAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAAC ATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGC ATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTAC GCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGG CATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATC ACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTAC GGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTG GGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAG AAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAG GAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAA GAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCC TGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAG CTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCAC GTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTT GGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGA GACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCC CACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGAC GAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAG GGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTG CAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAG ATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGA CTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCT AAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTG CTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGC AGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAG AAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGT ATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGC >In-frame_KDM4B_ENST00000381759_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_2829nt ATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAA TACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTAT GATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAG AAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGC AAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAAC ATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGC ATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTAC GCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGG CATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATC ACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTAC GGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTG GGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAG AAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAG GAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAA GAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCC TGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAG CTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCAC GTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTT GGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGA GACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCC CACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGAC GAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAG GGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTG CAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAG ATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGA CTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCT AAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTG CTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGC AGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAG AAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGT ATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGC >In-frame_KDM4B_ENST00000536461_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_2829nt ATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAA TACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTAT GATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAG AAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGC AAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAAC ATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGC ATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTAC GCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGG CATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATC ACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTAC GGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTG GGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAG AAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAG GAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAA GAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCC TGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAG CTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCAC GTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTT GGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGA GACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCC CACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGAC GAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAG GGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTG CAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAG ATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGA CTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCT AAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTG CTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGC AGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAG AAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGT ATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KDM4B_ENST00000159111_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_3414nt GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA GCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCA TCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCA TCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCT TCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCT TCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAG AATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGA AGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAG AGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGA AGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAA AAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAAC CAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTC GGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACC TCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGC GTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGG GTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATG AGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACG ATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGA AACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGG CTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGA CGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGG TCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGC ACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGC CTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATG TGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGA AGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGG CAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCG CTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGAC GTATGTAGAATGCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACG GACCTCCCCAAAGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAAT CTGCCCTTTAATAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAAT >In-frame_KDM4B_ENST00000381759_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_3403nt CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG TATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGC GTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTG CACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGC TCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATC ACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAAC TTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGAAGAACAAGCTC AGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAG CGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAG GAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAG GAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCA CAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACC GCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGG CAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGC GACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAAT AAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAA GAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTT GTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCC AAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGAC TGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCC TCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGG GAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACC CCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGG ATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTG CCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGC AGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAG GAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCT GGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGACGTATGTAGAAT GCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACGGACCTCCCCAA AGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAATCTGCCCTTTAA TAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAATGAATTGAAGCG >In-frame_KDM4B_ENST00000536461_chr19_5082515_+_CHAF1A_ENST00000301280_chr19_4418017_+_3236nt CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT CAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCAC CATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAG CATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTT CTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCC CTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGC AGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGA GAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAA AGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGA GAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGA AAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAA ACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCC TCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGA CCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGA GCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTG GGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGA TGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGA CGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCA GAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGC GGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCA GACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAA GGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCT GCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCG GCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTA TGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAG GAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCA GGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGC CGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTG ACGTATGTAGAATGCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCA CGGACCTCCCCAAAGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGA ATCTGCCCTTTAATAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAA |
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FusionGenePPI for KDM4B_CHAF1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KDM4B | KMT2D, ASH2L, RBBP5, WDR5, HNRNPU, HSPA4, ESR1, KMT2C, SMU1, HSP90AA2P, HSP90B1, H3F3C, ZNF414, DDX3X, NHP2L1, HIST1H2BG, CHORDC1, KDM4A, CCT3, CCT4, CCT6B, CCT2, CCT7, CCDC85C, CCT5, TCP1, CCT6A, CCT8, TRIM25, UHRF2 | CHAF1A | MBD1, ASF1B, BLM, CBX5, TCERG1, CHAF1B, PCNA, ASF1A, SUMO2, SUMO3, SUMO1, WRN, YWHAE, YWHAG, YWHAZ, DMAP1, RPA1, XPC, LZTR1, RBFOX2, PCBD2, SETDB1, CHAF1A, CDC7, CDK2, HIST1H3A, ANP32A, ANP32B, DDX41, EIF3C, GTF2I, HMGB2, NONO, PAF1, PRKDC, PRPF31, RBM3, RPS3, RPS9, SET, XRCC5, YWHAB, XRCC6, YWHAQ, HIST1H3E, MSH6, HIST4H4, CBX1, HIST1H4F, HIST2H3C, PABPC1, TOB1, TOB2, GFI1, HIST1H3B, CNOT6L, CNOT6, H3F3A, SQSTM1, RBBP4, CBX3, ZNF408, BECN1, ATG14, REL, TCF4, HIST3H3, NUSAP1, TCEB3, EWSR1, PIK3R1, TIGD6, TEAD2, HIST1H4A, P4HA3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KDM4B_CHAF1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KDM4B_CHAF1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KDM4B | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | CHAF1A | C0026636 | Mouth Diseases | 1 | CTD_human |
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