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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18443

FusionGeneSummary for KDM4A_OPRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4A_OPRD1
Fusion gene ID: 18443
HgeneTgene
Gene symbol

KDM4A

OPRD1

Gene ID

9682

4985

Gene namelysine demethylase 4Aopioid receptor delta 1
SynonymsJHDM3A|JMJD2|JMJD2A|TDRD14AOPRD
Cytomap

1p34.2-p34.1

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4AjmjC domain-containing histone demethylation protein 3Ajumonji C domain-containing histone demethylase 3Ajumonji domain containing 2jumonji domain containing 2Ajumonji domain-containing protein 2Alysine (K)-specific demdelta-type opioid receptorD-OR-1DOR-1delta opioid receptor 1
Modification date2018052320180523
UniProtAcc

O75164

P41143

Ensembl transtripts involved in fusion geneENST00000372396, ENST00000463151, 
ENST00000234961, 
Fusion gene scores* DoF score13 X 12 X 9=14041 X 1 X 1=1
# samples 131
** MAII scorelog2(13/1404*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: KDM4A [Title/Abstract] AND OPRD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4A

GO:0016577

histone demethylation

16024779

HgeneKDM4A

GO:0045892

negative regulation of transcription, DNA-templated

16024779

HgeneKDM4A

GO:0070544

histone H3-K36 demethylation

21914792

TgeneOPRD1

GO:0000060

protein import into nucleus, translocation

16325578

TgeneOPRD1

GO:0007186

G-protein coupled receptor signaling pathway

16325578

TgeneOPRD1

GO:0010629

negative regulation of gene expression

24613828

TgeneOPRD1

GO:0032460

negative regulation of protein oligomerization

24613828

TgeneOPRD1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

24613828

TgeneOPRD1

GO:0051881

regulation of mitochondrial membrane potential

24613828

TgeneOPRD1

GO:0071456

cellular response to hypoxia

24613828

TgeneOPRD1

GO:0097237

cellular response to toxic substance

24613828


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCHOLTCGA-W5-AA36-01AKDM4Achr1

44121437

+OPRD1chr1

29185466

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372396ENST00000234961KDM4Achr1

44121437

+OPRD1chr1

29185466

+
3UTR-3CDSENST00000463151ENST00000234961KDM4Achr1

44121437

+OPRD1chr1

29185466

+

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FusionProtFeatures for KDM4A_OPRD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4A

O75164

OPRD1

P41143

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a centralrole in histone code (PubMed:26741168). Does not demethylatehistone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylatestrimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has noactivity on mono- and dimethylated residues. Demethylation of Lysresidue generates formaldehyde and succinate. Participates intranscriptional repression of ASCL2 and E2F-responsive promotersvia the recruitment of histone deacetylases and NCOR1,respectively. {ECO:0000269|PubMed:16024779,ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}. Isoform 2: Crucial for muscle differentiation, promotestranscriptional activation of the Myog gene by directing theremoval of repressive chromatin marks at its promoter. Lacks theN-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. G-protein coupled receptor that functions as receptorfor endogenous enkephalins and for a subset of other opioids.Ligand binding causes a conformation change that triggerssignaling via guanine nucleotide-binding proteins (G proteins) andmodulates the activity of down-stream effectors, such as adenylatecyclase. Signaling leads to the inhibition of adenylate cyclaseactivity. Inhibits neurotransmitter release by reducing calciumion currents and increasing potassium ion conductance. Plays arole in the perception of pain and in opiate-mediated analgesia.Plays a role in developing analgesic tolerance to morphine.{ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419,ECO:0000269|PubMed:8201839}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+32214_561041065DomainJmjN
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03111_12275373Topological domainExtracellular
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03145_16375373Topological domainCytoplasmic
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03187_20675373Topological domainExtracellular
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03239_26175373Topological domainCytoplasmic
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03285_29975373Topological domainExtracellular
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03322_37275373Topological domainCytoplasmic
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+0376_8575373Topological domainCytoplasmic
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03123_14475373TransmembraneHelical%3B Name%3D3
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03164_18675373TransmembraneHelical%3B Name%3D4
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03207_23875373TransmembraneHelical%3B Name%3D5
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03262_28475373TransmembraneHelical%3B Name%3D6
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+03300_32175373TransmembraneHelical%3B Name%3D7
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+0386_11075373TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322142_3081041065DomainJmjC
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322897_9541041065DomainNote=Tudor 1
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322955_10111041065DomainNote=Tudor 2
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322709_7671041065Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322772_8051041065Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322828_8851041065Zinc fingerPHD-type 2
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+031_4775373Topological domainExtracellular
TgeneOPRD1chr1:44121437chr1:29185466ENST00000234961+0348_7575373TransmembraneHelical%3B Name%3D1


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FusionGeneSequence for KDM4A_OPRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KDM4A_ENST00000372396_chr1_44121437_+_OPRD1_ENST00000234961_chr1_29185466_+_402aa
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVC
HPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLR
SVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KDM4A_ENST00000372396_chr1_44121437_+_OPRD1_ENST00000234961_chr1_29185466_+_1206nt
ATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGACCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATAC
ATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCAAGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGAT
GACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGACGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAA
GCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGTACACTAAGATGAAGACGGCCACCAACATCTACATCTTCAACCTG
GCCTTAGCCGATGCGCTGGCCACCAGCACGCTGCCTTTCCAGAGTGCCAAGTACCTGATGGAGACGTGGCCCTTCGGCGAGCTGCTCTGC
AAGGCTGTGCTCTCCATCGACTACTACAATATGTTCACCAGCATCTTCACGCTCACCATGATGAGTGTTGACCGCTACATCGCTGTCTGC
CACCCTGTCAAGGCCCTGGACTTCCGCACGCCTGCCAAGGCCAAGCTGATCAACATCTGTATCTGGGTCCTGGCCTCAGGCGTTGGCGTG
CCCATCATGGTCATGGCTGTGACCCGTCCCCGGGACGGGGCAGTGGTGTGCATGCTCCAGTTCCCCAGCCCCAGCTGGTACTGGGACACG
GTGACCAAGATCTGCGTGTTCCTCTTCGCCTTCGTGGTGCCCATCCTCATCATCACCGTGTGCTATGGCCTCATGCTGCTGCGCCTGCGC
AGTGTGCGCCTGCTGTCGGGCTCCAAGGAGAAGGACCGCAGCCTGCGGCGCATCACGCGCATGGTGCTGGTGGTTGTGGGCGCCTTCGTG
GTGTGTTGGGCGCCCATCCACATCTTCGTCATCGTCTGGACGCTGGTGGACATCGACCGGCGCGACCCGCTGGTGGTGGCTGCGCTGCAC
CTGTGCATCGCGCTGGGCTACGCCAATAGCAGCCTCAACCCCGTGCTCTACGCTTTCCTCGACGAGAACTTCAAGCGCTGCTTCCGCCAG
CTCTGCCGCAAGCCCTGCGGCCGCCCAGACCCCAGCAGCTTCAGCCGCGCCCGCGAAGCCACGGCCCGCGAGCGTGTCACCGCCTGCACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_KDM4A_ENST00000372396_chr1_44121437_+_OPRD1_ENST00000234961_chr1_29185466_+_1753nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACACTAAGATGAAGACGGCCACCAACATCTACATCTTCAACCTGGCCTTAGCCGATGCGCTGGCCACCAGCACGCTGCCTTTCCAGAGTG
CCAAGTACCTGATGGAGACGTGGCCCTTCGGCGAGCTGCTCTGCAAGGCTGTGCTCTCCATCGACTACTACAATATGTTCACCAGCATCT
TCACGCTCACCATGATGAGTGTTGACCGCTACATCGCTGTCTGCCACCCTGTCAAGGCCCTGGACTTCCGCACGCCTGCCAAGGCCAAGC
TGATCAACATCTGTATCTGGGTCCTGGCCTCAGGCGTTGGCGTGCCCATCATGGTCATGGCTGTGACCCGTCCCCGGGACGGGGCAGTGG
TGTGCATGCTCCAGTTCCCCAGCCCCAGCTGGTACTGGGACACGGTGACCAAGATCTGCGTGTTCCTCTTCGCCTTCGTGGTGCCCATCC
TCATCATCACCGTGTGCTATGGCCTCATGCTGCTGCGCCTGCGCAGTGTGCGCCTGCTGTCGGGCTCCAAGGAGAAGGACCGCAGCCTGC
GGCGCATCACGCGCATGGTGCTGGTGGTTGTGGGCGCCTTCGTGGTGTGTTGGGCGCCCATCCACATCTTCGTCATCGTCTGGACGCTGG
TGGACATCGACCGGCGCGACCCGCTGGTGGTGGCTGCGCTGCACCTGTGCATCGCGCTGGGCTACGCCAATAGCAGCCTCAACCCCGTGC
TCTACGCTTTCCTCGACGAGAACTTCAAGCGCTGCTTCCGCCAGCTCTGCCGCAAGCCCTGCGGCCGCCCAGACCCCAGCAGCTTCAGCC
GCGCCCGCGAAGCCACGGCCCGCGAGCGTGTCACCGCCTGCACCCCGTCCGATGGTCCCGGCGGTGGCGCTGCCGCCTGACCAGGCCATC
CGGCCCCCAGAGCGCCCCTCCCTAGTGACCCGGAGGCCACATGAGTCCCAGTGGGAGGCGCGAGCCATGATGTGGAGTGGGGCAGTAGAA
GGTCGGAGGCTTGGGACCGCCAGATGGGGCCTCTGTTTCGGAGACGGGACCGGGCCGCTAGATGGGCATGGGGTGGGCCTCTGGTTTGGG
GCGAGGCAGAGGACAGATCAATGGCGCAGTGCCTCTGGTCTGGGTGCCCCGTCCACGGCTCTAGGTGGGGCGGGAAAGCCAGTGACTCCA
GGAGAGGAGCGGGACCTGTGGCTCTACAACTGAGTCCTTAAACAGGGCATCTCCAGGAAGGCGGGGCTTCAACCTTGAGACAGCTTCGGT


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FusionGenePPI for KDM4A_OPRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KDM4ANCOR1, WDR48, KDM4A, KDM4C, HIST1H3A, HDAC1, HDAC3, RB1, AR, WAS, HIST1H4A, RNF8, RNF168, H3F3A, CUL1, FBXL4, MOV10, NXF1, CAPZA1, EPHB2, ZNF131, ZNF414, CCL22, STK11, KDM4B, ABHD5OPRD1GPRASP1, OPRD1, ADRB2, ARRB1, ARRB2, OPRM1, GNAO1, CANX, HSPA4, SEC61A1, AUP1, GJA4, DOK4, SIAH1, SIAH2, VAPA, WLS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM4Achr1:44121437chr1:29185466ENST00000372396+322597_6381041065NCOR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KDM4A_OPRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneOPRD1P41143DB00321AmitriptylineDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00333MethadoneDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00514DextromethorphanDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00836LoperamideDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00844NalbuphineDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00899RemifentanilDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB06204TapentadolDelta-type opioid receptorsmall moleculeapproved
TgeneOPRD1P41143DB00318CodeineDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB00327HydromorphoneDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB00956HydrocodoneDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB01081DiphenoxylateDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB09209PholcodineDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB11130OpiumDelta-type opioid receptorsmall moleculeapproved|illicit
TgeneOPRD1P41143DB00497OxycodoneDelta-type opioid receptorsmall moleculeapproved|illicit|investigational
TgeneOPRD1P41143DB01452HeroinDelta-type opioid receptorsmall moleculeapproved|illicit|investigational
TgeneOPRD1P41143DB00813FentanylDelta-type opioid receptorsmall moleculeapproved|illicit|investigational|vet_approved
TgeneOPRD1P41143DB00921BuprenorphineDelta-type opioid receptorsmall moleculeapproved|illicit|investigational|vet_approved
TgeneOPRD1P41143DB00647DextropropoxypheneDelta-type opioid receptorsmall moleculeapproved|illicit|investigational|withdrawn
TgeneOPRD1P41143DB00611ButorphanolDelta-type opioid receptorsmall moleculeapproved|illicit|vet_approved
TgeneOPRD1P41143DB00193TramadolDelta-type opioid receptorsmall moleculeapproved|investigational
TgeneOPRD1P41143DB00295MorphineDelta-type opioid receptorsmall moleculeapproved|investigational
TgeneOPRD1P41143DB00708SufentanilDelta-type opioid receptorsmall moleculeapproved|investigational
TgeneOPRD1P41143DB06274AlvimopanDelta-type opioid receptorsmall moleculeapproved|investigational
TgeneOPRD1P41143DB06738KetobemidoneDelta-type opioid receptorsmall moleculeapproved|investigational
TgeneOPRD1P41143DB00704NaltrexoneDelta-type opioid receptorsmall moleculeapproved|investigational|vet_approved
TgeneOPRD1P41143DB06230NalmefeneDelta-type opioid receptorsmall moleculeapproved|investigational|withdrawn
TgeneOPRD1P41143DB01183NaloxoneDelta-type opioid receptorsmall moleculeapproved|vet_approved
TgeneOPRD1P41143DB01221KetamineDelta-type opioid receptorsmall moleculeapproved|vet_approved

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RelatedDiseases for KDM4A_OPRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneOPRD1C0001973Alcoholic Intoxication, Chronic4PSYGENET
TgeneOPRD1C0236969Substance-Related Disorders2CTD_human
TgeneOPRD1C0600427Cocaine Dependence2PSYGENET
TgeneOPRD1C0014544Epilepsy1CTD_human
TgeneOPRD1C0020651Hypotension, Orthostatic1CTD_human
TgeneOPRD1C0033975Psychotic Disorders1PSYGENET
TgeneOPRD1C0038587Substance Withdrawal Syndrome1CTD_human
TgeneOPRD1C0349204Nonorganic psychosis1PSYGENET