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Fusion gene ID: 18378 |
FusionGeneSummary for KCTD5_TSC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCTD5_TSC2 | Fusion gene ID: 18378 | Hgene | Tgene | Gene symbol | KCTD5 | TSC2 | Gene ID | 54442 | 7249 |
| Gene name | potassium channel tetramerization domain containing 5 | TSC complex subunit 2 | |
| Synonyms | - | LAM|PPP1R160|TSC4 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BTB/POZ domain-containing protein KCTD5potassium channel tetramerisation domain containing 5 | tuberinprotein phosphatase 1, regulatory subunit 160tuberous sclerosis 2 protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9NXV2 | P49815 | |
| Ensembl transtripts involved in fusion gene | ENST00000301738, ENST00000564195, ENST00000569689, | ENST00000219476, ENST00000382538, ENST00000401874, ENST00000353929, ENST00000439673, ENST00000350773, ENST00000568454, ENST00000568366, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 1=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: KCTD5 [Title/Abstract] AND TSC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5J1-01A | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301738 | ENST00000219476 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000382538 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000401874 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000353929 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000439673 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000350773 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| In-frame | ENST00000301738 | ENST00000568454 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| 5CDS-intron | ENST00000301738 | ENST00000568366 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000219476 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000382538 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000401874 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000353929 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000439673 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000350773 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000564195 | ENST00000568454 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-intron | ENST00000564195 | ENST00000568366 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000219476 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000382538 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000401874 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000353929 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000439673 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000350773 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-3CDS | ENST00000569689 | ENST00000568454 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
| intron-intron | ENST00000569689 | ENST00000568366 | KCTD5 | chr16 | 2747998 | + | TSC2 | chr16 | 2136194 | + |
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FusionProtFeatures for KCTD5_TSC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCTD5 | TSC2 |
| Its interaction with CUL3 suggests that it may act as asubstrate adapter in some E3 ligase complex. Does not affect thefunction of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 andKv3.4/KCNC4. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KCTD5 | chr16:2747998 | chr16:2136194 | ENST00000301738 | + | 3 | 6 | 44_146 | 151 | 235 | Domain | Note=BTB |
| Tgene | >TSC2 | chr16:2747998 | chr16:2136194 | ENST00000350773 | + | 34 | 41 | 1531_1758 | 1531 | 1785 | Domain | Rap-GAP |
| Tgene | >TSC2 | chr16:2747998 | chr16:2136194 | ENST00000353929 | + | 34 | 41 | 1531_1758 | 1511 | 1765 | Domain | Rap-GAP |
| Tgene | >TSC2 | chr16:2747998 | chr16:2136194 | ENST00000401874 | + | 33 | 40 | 1531_1758 | 1487 | 1741 | Domain | Rap-GAP |
| Tgene | >TSC2 | chr16:2747998 | chr16:2136194 | ENST00000439673 | + | 32 | 39 | 1531_1758 | 1451 | 1705 | Domain | Rap-GAP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TSC2 | chr16:2747998 | chr16:2136194 | ENST00000219476 | + | 35 | 42 | 1531_1758 | 1554 | 1808 | Domain | Rap-GAP |
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FusionGeneSequence for KCTD5_TSC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000219476_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000382538_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000401874_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000353929_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000439673_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000350773_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000568454_chr16_2136194_+_405aa MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000219476_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000382538_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000401874_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000353929_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000439673_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000350773_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000568454_chr16_2136194_+_1215nt ATGGCGGAGAATCACTGCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCT GGGCTCGGCGCCCTGGCCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAG ACCCTGTGCCGGGACCCGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTAT TTAATCGACAGAGACCCCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAA GGAGTGTTGGAGGAAGCAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCG CAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAG CTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGAC ATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAAC GACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTC ACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTG TCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACC GATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCC AGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000219476_chr16_2136194_+_1391nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000382538_chr16_2136194_+_1379nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000401874_chr16_2136194_+_1381nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000353929_chr16_2136194_+_1390nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000439673_chr16_2136194_+_1380nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000350773_chr16_2136194_+_1391nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA >In-frame_KCTD5_ENST00000301738_chr16_2747998_+_TSC2_ENST00000568454_chr16_2136194_+_1394nt ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA |
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FusionGenePPI for KCTD5_TSC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KCTD5 | TRIP6, CUL2, CUL3, KCTD5, GORASP2, GRK5, SMURF1, PAN2, NPM1, SOX2, EP300, NEK6, CD1A, PRKAB2, GIT2, NXF1, RAPGEF2, KCTD17, ARRDC1, CNRIP1, XPO1, POLK, GAN, ZNF711, MCM7, FAM193B, PDZK1, KCND2, PRDX2, SLC9A3R2, C21orf2, CYLD | TSC2 | YWHAQ, RHEB, RAP1A, RALA, YWHAZ, AKT1, CAV1, FOXO1, GSK3B, PAM, PRKAA1, PTK2, RAB5A, RPS6KA1, TSC1, CCND1, CCND2, CCND3, PLK1, MAPK1, UBE3A, AXIN1, FBXW5, TBC1D7, YWHAB, GRB2, TK1, PIN1, HERC1, CDKN1B, LNX1, NEK1, CALM1, C12orf5, ESR1, YWHAE, SMAD2, SMAD3, HECW2, CIAO1, MDFI, SPERT, SIRT1, DAPK1, RRAGA, RRAGB, RRAGC, RRAGD, SPINT2, PNKD, RP2, PRKCSH, ALDH3A2, NTRK1, POU5F1, COL20A1, CD79B, CD83, SIGLECL1, P4HA3, FAM221B, P4HA2, CBY1, RUVBL2, TSC2, YWHAG, WDR92 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCTD5_TSC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KCTD5_TSC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TSC2 | C1860707 | TUBEROUS SCLEROSIS 2 (disorder) | 13 | CTD_human;UNIPROT |
| Tgene | TSC2 | C0041341 | Tuberous Sclerosis | 4 | CTD_human;ORPHANET |
| Tgene | TSC2 | C0022665 | Kidney Neoplasm | 3 | CTD_human |
| Tgene | TSC2 | C0004352 | Autistic Disorder | 1 | CTD_human;HPO |
| Tgene | TSC2 | C0006111 | Brain Diseases | 1 | CTD_human |
| Tgene | TSC2 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | TSC2 | C0014544 | Epilepsy | 1 | CTD_human;HPO |
| Tgene | TSC2 | C0023267 | Fibroid Tumor | 1 | CTD_human |
| Tgene | TSC2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | TSC2 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Tgene | TSC2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | TSC2 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | TSC2 | C0036572 | Seizures | 1 | CTD_human;HPO |
| Tgene | TSC2 | C0037769 | West Syndrome | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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