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Fusion gene ID: 18347 |
FusionGeneSummary for KCP_CKLF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCP_CKLF | Fusion gene ID: 18347 | Hgene | Tgene | Gene symbol | KCP | CKLF | Gene ID | 375616 | 51192 |
| Gene name | kielin/chordin-like protein | chemokine like factor | |
| Synonyms | CRIM2|KCP1|NET67 | C32|CKLF1|CKLF2|CKLF3|CKLF4|HSPC224|UCK-1 | |
| Cytomap | 7q32.1 | 16q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kielin/chordin-like proteinCRIM-2KCP-1cysteine rich BMP regulator 2 (chordin-like)cysteine-rich BMP regulator 2cysteine-rich motor neuron 2 proteinkielinkielin/chordin-like protein 1 | chemokine-like factorchemokine-like factor 1chemokine-like factor 2chemokine-like factor 3chemokine-like factor 4transmembrane proteolipid | |
| Modification date | 20180408 | 20180523 | |
| UniProtAcc | Q9UBR5 | ||
| Ensembl transtripts involved in fusion gene | ENST00000476647, | ENST00000264001, ENST00000362093, ENST00000351137, ENST00000345436, ENST00000417030, ENST00000563092, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KCP [Title/Abstract] AND CKLF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CKLF | GO:0008283 | cell proliferation | 11415443 |
| Tgene | CKLF | GO:0030593 | neutrophil chemotaxis | 11415443 |
| Tgene | CKLF | GO:0032940 | secretion by cell | 11415443 |
| Tgene | CKLF | GO:0048246 | macrophage chemotaxis | 11415443 |
| Tgene | CKLF | GO:0048247 | lymphocyte chemotaxis | 11415443 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC068076 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000476647 | ENST00000264001 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| intron-intron | ENST00000476647 | ENST00000362093 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| intron-intron | ENST00000476647 | ENST00000351137 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| intron-intron | ENST00000476647 | ENST00000345436 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| intron-intron | ENST00000476647 | ENST00000417030 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
| intron-intron | ENST00000476647 | ENST00000563092 | KCP | chr7 | 128507727 | - | CKLF | chr16 | 66596067 | + |
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FusionProtFeatures for KCP_CKLF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCP | CKLF |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May play an important role in inflammation andregeneration of skeletal muscle. Partly inhibited by interleukin10. {ECO:0000269|PubMed:11415443}. Isoform 1: has chemotactic response in monocytes,neutrophils and lymphocytes (PubMed:11415443). Binds CCR4(PubMed:16137713). {ECO:0000269|PubMed:11415443,ECO:0000269|PubMed:16137713}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KCP_CKLF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KCP_CKLF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCP_CKLF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KCP_CKLF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CKLF | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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