![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 18328 |
FusionGeneSummary for KCNQ1_LSP1 |
![]() |
Fusion gene information | Fusion gene name: KCNQ1_LSP1 | Fusion gene ID: 18328 | Hgene | Tgene | Gene symbol | KCNQ1 | LSP1 | Gene ID | 3784 | 4046 |
Gene name | potassium voltage-gated channel subfamily Q member 1 | lymphocyte specific protein 1 | |
Synonyms | ATFB1|ATFB3|JLNS1|KCNA8|KCNA9|KVLQT1|Kv1.9|Kv7.1|LQT|LQT1|RWS|SQT2|WRS | WP34|pp52 | |
Cytomap | 11p15.5-p15.4 | 11p15.5 | |
Type of gene | protein-coding | protein-coding | |
Description | potassium voltage-gated channel subfamily KQT member 1IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1kidney and cardiac voltage dependend K+ channelpotassium channel, voltage gated KQT-like subfamily Q, member 1potassium voltag | lymphocyte-specific protein 147 kDa actin binding protein52 kDa phosphoproteinF-actin binding and cytoskeleton associated proteinleufactin (leukocyte F-actin binding protein)leukocyte-specific protein 1lymphocyte-specific antigen WP34 | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P51787 | P33241 | |
Ensembl transtripts involved in fusion gene | ENST00000155840, ENST00000335475, ENST00000526095, | ENST00000311604, ENST00000381775, ENST00000405957, ENST00000406638, ENST00000485341, ENST00000599825, | |
Fusion gene scores | * DoF score | 12 X 8 X 8=768 | 6 X 5 X 3=90 |
# samples | 12 | 6 | |
** MAII score | log2(12/768*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KCNQ1 [Title/Abstract] AND LSP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KCNQ1 | GO:0035690 | cellular response to drug | 9108097 |
Hgene | KCNQ1 | GO:0060306 | regulation of membrane repolarization | 11299204 |
Hgene | KCNQ1 | GO:0071320 | cellular response to cAMP | 11299204|16002409 |
Hgene | KCNQ1 | GO:0071435 | potassium ion export | 8900283|10400998 |
Hgene | KCNQ1 | GO:0071805 | potassium ion transmembrane transport | 9354802|11299204|16002409 |
Hgene | KCNQ1 | GO:0086011 | membrane repolarization during action potential | 8900283|11299204|19646991 |
Hgene | KCNQ1 | GO:0097623 | potassium ion export across plasma membrane | 17289006 |
Hgene | KCNQ1 | GO:1901381 | positive regulation of potassium ion transmembrane transport | 8900283 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-NF-A4WX-01A | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000155840 | ENST00000311604 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
In-frame | ENST00000155840 | ENST00000381775 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
5CDS-5UTR | ENST00000155840 | ENST00000405957 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
5CDS-5UTR | ENST00000155840 | ENST00000406638 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
5CDS-intron | ENST00000155840 | ENST00000485341 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
5CDS-intron | ENST00000155840 | ENST00000599825 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-3CDS | ENST00000335475 | ENST00000311604 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-3CDS | ENST00000335475 | ENST00000381775 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-5UTR | ENST00000335475 | ENST00000405957 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-5UTR | ENST00000335475 | ENST00000406638 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-intron | ENST00000335475 | ENST00000485341 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-intron | ENST00000335475 | ENST00000599825 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-3CDS | ENST00000526095 | ENST00000311604 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-3CDS | ENST00000526095 | ENST00000381775 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-5UTR | ENST00000526095 | ENST00000405957 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-5UTR | ENST00000526095 | ENST00000406638 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-intron | ENST00000526095 | ENST00000485341 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
intron-intron | ENST00000526095 | ENST00000599825 | KCNQ1 | chr11 | 2466714 | + | LSP1 | chr11 | 1901317 | + |
Top |
FusionProtFeatures for KCNQ1_LSP1 |
![]() |
Hgene | Tgene |
KCNQ1 | LSP1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 1_121 | 128 | 677 | Topological domain | Cytoplasmic |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 585_621 | 128 | 677 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 585_621 | -92 | 550 | Coiled coil | Ontology_term=ECO:0000269 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 300_320 | 128 | 677 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 300_320 | -92 | 550 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 312_317 | 128 | 677 | Motif | Selectivity filter |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 312_317 | -92 | 550 | Motif | Selectivity filter |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 589_620 | 128 | 677 | Region | C-terminal assembly domain |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 589_620 | -92 | 550 | Region | C-terminal assembly domain |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 143_147 | 128 | 677 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 169_196 | 128 | 677 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 218_225 | 128 | 677 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 249_261 | 128 | 677 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 283_299 | 128 | 677 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 321_327 | 128 | 677 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 349_676 | 128 | 677 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 143_147 | -92 | 550 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 169_196 | -92 | 550 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 1_121 | -92 | 550 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 218_225 | -92 | 550 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 249_261 | -92 | 550 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 283_299 | -92 | 550 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 321_327 | -92 | 550 | Topological domain | Extracellular |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 349_676 | -92 | 550 | Topological domain | Cytoplasmic |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 122_142 | 128 | 677 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 148_168 | 128 | 677 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 197_217 | 128 | 677 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 226_248 | 128 | 677 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 262_282 | 128 | 677 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 328_348 | 128 | 677 | Transmembrane | Helical%3B Name%3DSegment S6 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 122_142 | -92 | 550 | Transmembrane | Helical%3B Name%3DSegment S1 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 148_168 | -92 | 550 | Transmembrane | Helical%3B Name%3DSegment S2 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 197_217 | -92 | 550 | Transmembrane | Helical%3B Name%3DSegment S3 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 226_248 | -92 | 550 | Transmembrane | Helical%3B Voltage-sensor%3B Name%3DSegment S4 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 262_282 | -92 | 550 | Transmembrane | Helical%3B Name%3DSegment S5 |
Hgene | >KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 328_348 | -92 | 550 | Transmembrane | Helical%3B Name%3DSegment S6 |
Top |
FusionGeneSequence for KCNQ1_LSP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000311604_chr11_1901317_+_451aa MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPR VSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKP SEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAG AEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLAR QASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP >In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000381775_chr11_1901317_+_451aa MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPR VSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKP SEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAG AEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLAR QASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000311604_chr11_1901317_+_1353nt ATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGGCGGGGCAGCGCGGGCCTG GCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGCGCCCGGCGCCCCAGGT CCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCGGTGAGCCTAGACCCGCGC GTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGAGCGTCCCACCGGCTGG AAATGCTTCGTTTACCACTTCGCCGTGCCCACTGCTCAGTGGAGCGTGGAGGACGAGGAGGAGGCCGTCCACGAGCAATGCCAGCATGAG AGAGACAGGCAGCTTCAGGCCCAGGACGAGGAGGGAGGCGGCCATGTCCCCGAGCGGCCGAAGCAGGAGATGCTCCTCAGCCTGAAGCCC TCGGAGGCCCCTGAACTGGATGAGGACGAGGGCTTTGGCGACTGGTCCCAGAGGCCAGAGCAGCGGCAGCAGCACGAGGGGGCGCAGGGC GCCTTGGACAGCGGAGAGCCCCCCCAGTGCAGGAGTCCTGAGGGGGAGCAAGAGGACAGGCCCGGCCTGCATGCCTACGAAAAGGAGGAC AGTGATGAAGTCCACCTGGAGGAGTTGAGTCTGAGCAAGGAGGGGCCAGGCCCAGAGGACACTGTCCAGGACAACCTGGGGGCCGCAGGG GCTGAGGAGGAACAGGAGGAGCACCAGAAATGTCAGCAGCCCAGGACACCCAGCCCCTTGGTCTTGGAGGGGACCATCGAACAGAGCTCG CCTCCCCTGAGCCCTACCACCAAACTCATCGACAGGACCGAGTCCCTAAACCGCTCCATAGAGAAGAGTAACAGTGTGAAGAAATCCCAG CCAGACTTGCCCATCTCCAAGATTGATCAGTGGCTGGAACAATACACCCAGGCCATCGAGACCGCTGGCCGGACCCCCAAGCTAGCCCGC CAGGCCTCCATAGAGCTGCCCAGCATGGCTGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAGGCTCAGTCTGCGGCCAAG ACTCCGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAAGAAAAGCCTCTGGGAGCAGAAGGGAGGCTCCAAGACCTCATCAACAATT AAGAGCACCCCATCTGGGAAGAGGTATAAGTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTGGAAGGGGGCCCGGCTCCC >In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000381775_chr11_1901317_+_1353nt ATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGGCGGGGCAGCGCGGGCCTG GCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGCGCCCGGCGCCCCAGGT CCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCGGTGAGCCTAGACCCGCGC GTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGAGCGTCCCACCGGCTGG AAATGCTTCGTTTACCACTTCGCCGTGCCCACTGCTCAGTGGAGCGTGGAGGACGAGGAGGAGGCCGTCCACGAGCAATGCCAGCATGAG AGAGACAGGCAGCTTCAGGCCCAGGACGAGGAGGGAGGCGGCCATGTCCCCGAGCGGCCGAAGCAGGAGATGCTCCTCAGCCTGAAGCCC TCGGAGGCCCCTGAACTGGATGAGGACGAGGGCTTTGGCGACTGGTCCCAGAGGCCAGAGCAGCGGCAGCAGCACGAGGGGGCGCAGGGC GCCTTGGACAGCGGAGAGCCCCCCCAGTGCAGGAGTCCTGAGGGGGAGCAAGAGGACAGGCCCGGCCTGCATGCCTACGAAAAGGAGGAC AGTGATGAAGTCCACCTGGAGGAGTTGAGTCTGAGCAAGGAGGGGCCAGGCCCAGAGGACACTGTCCAGGACAACCTGGGGGCCGCAGGG GCTGAGGAGGAACAGGAGGAGCACCAGAAATGTCAGCAGCCCAGGACACCCAGCCCCTTGGTCTTGGAGGGGACCATCGAACAGAGCTCG CCTCCCCTGAGCCCTACCACCAAACTCATCGACAGGACCGAGTCCCTAAACCGCTCCATAGAGAAGAGTAACAGTGTGAAGAAATCCCAG CCAGACTTGCCCATCTCCAAGATTGATCAGTGGCTGGAACAATACACCCAGGCCATCGAGACCGCTGGCCGGACCCCCAAGCTAGCCCGC CAGGCCTCCATAGAGCTGCCCAGCATGGCTGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAGGCTCAGTCTGCGGCCAAG ACTCCGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAAGAAAAGCCTCTGGGAGCAGAAGGGAGGCTCCAAGACCTCATCAACAATT AAGAGCACCCCATCTGGGAAGAGGTATAAGTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTGGAAGGGGGCCCGGCTCCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000311604_chr11_1901317_+_1965nt GCGGCGGGGCTGGCAGCAGTGGCTGCCCGCACTGCGCCCGGGCGCTCGCCTTCGCTGCAGCTCCCGGTGCCGCCGCTCGGGCCGGCCCCC CGGCAGGCCCTCCTCGTTATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGG CGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATC GCGCCCGGCGCCCCAGGTCCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCG GTGAGCCTAGACCCGCGCGTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTC GAGCGTCCCACCGGCTGGAAATGCTTCGTTTACCACTTCGCCGTGCCCACTGCTCAGTGGAGCGTGGAGGACGAGGAGGAGGCCGTCCAC GAGCAATGCCAGCATGAGAGAGACAGGCAGCTTCAGGCCCAGGACGAGGAGGGAGGCGGCCATGTCCCCGAGCGGCCGAAGCAGGAGATG CTCCTCAGCCTGAAGCCCTCGGAGGCCCCTGAACTGGATGAGGACGAGGGCTTTGGCGACTGGTCCCAGAGGCCAGAGCAGCGGCAGCAG CACGAGGGGGCGCAGGGCGCCTTGGACAGCGGAGAGCCCCCCCAGTGCAGGAGTCCTGAGGGGGAGCAAGAGGACAGGCCCGGCCTGCAT GCCTACGAAAAGGAGGACAGTGATGAAGTCCACCTGGAGGAGTTGAGTCTGAGCAAGGAGGGGCCAGGCCCAGAGGACACTGTCCAGGAC AACCTGGGGGCCGCAGGGGCTGAGGAGGAACAGGAGGAGCACCAGAAATGTCAGCAGCCCAGGACACCCAGCCCCTTGGTCTTGGAGGGG ACCATCGAACAGAGCTCGCCTCCCCTGAGCCCTACCACCAAACTCATCGACAGGACCGAGTCCCTAAACCGCTCCATAGAGAAGAGTAAC AGTGTGAAGAAATCCCAGCCAGACTTGCCCATCTCCAAGATTGATCAGTGGCTGGAACAATACACCCAGGCCATCGAGACCGCTGGCCGG ACCCCCAAGCTAGCCCGCCAGGCCTCCATAGAGCTGCCCAGCATGGCTGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAG GCTCAGTCTGCGGCCAAGACTCCGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAAGAAAAGCCTCTGGGAGCAGAAGGGAGGCTCC AAGACCTCATCAACAATTAAGAGCACCCCATCTGGGAAGAGGTATAAGTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTG GAAGGGGGCCCGGCTCCCTAGGCGTCCCATCTCGCTTCCTGGGTCTGCAGGTCCAGCCGGCTGGCACCCTCCATGTACCCAGGGGAGATT CCAGCCAGACACCCGCCCCCCGGCCCTGGCTAAGAAGTTGCTTCCTGTTGCCAGCATGACCTACCCTCGCCTCTTTGATGCCATCCGCTG CCACCTCCTTTTGCTCCTGGACCCTTTAGCCTCTCTGCCCTTCCACTCTCTGACCACCGCCCCCGCCCTCCCCACCCAGCTCCGCTTCTT GTTACTTGGGGGAGGAAAGAAACTCCTGATCATTGGCCAAAGGGACTTACCCCTGGAGAGGCCAAGTGCCTTCTAGGAAGTTAGGAGGTT GAGGCACAGCCTGTGCAGAGAGGGTGGGTCACCCCCCCAGATCCAAGGAGAAACTGCAGGTCAAGGGCTGATAACGGCCATGCAGGATGC >In-frame_KCNQ1_ENST00000155840_chr11_2466714_+_LSP1_ENST00000381775_chr11_1901317_+_1965nt GCGGCGGGGCTGGCAGCAGTGGCTGCCCGCACTGCGCCCGGGCGCTCGCCTTCGCTGCAGCTCCCGGTGCCGCCGCTCGGGCCGGCCCCC CGGCAGGCCCTCCTCGTTATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTGCCAGGCGCCCGG CGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCCCTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATC GCGCCCGGCGCCCCAGGTCCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGCCCGCGGCCGCCG GTGAGCCTAGACCCGCGCGTCTCCATCTACAGCACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTC GAGCGTCCCACCGGCTGGAAATGCTTCGTTTACCACTTCGCCGTGCCCACTGCTCAGTGGAGCGTGGAGGACGAGGAGGAGGCCGTCCAC GAGCAATGCCAGCATGAGAGAGACAGGCAGCTTCAGGCCCAGGACGAGGAGGGAGGCGGCCATGTCCCCGAGCGGCCGAAGCAGGAGATG CTCCTCAGCCTGAAGCCCTCGGAGGCCCCTGAACTGGATGAGGACGAGGGCTTTGGCGACTGGTCCCAGAGGCCAGAGCAGCGGCAGCAG CACGAGGGGGCGCAGGGCGCCTTGGACAGCGGAGAGCCCCCCCAGTGCAGGAGTCCTGAGGGGGAGCAAGAGGACAGGCCCGGCCTGCAT GCCTACGAAAAGGAGGACAGTGATGAAGTCCACCTGGAGGAGTTGAGTCTGAGCAAGGAGGGGCCAGGCCCAGAGGACACTGTCCAGGAC AACCTGGGGGCCGCAGGGGCTGAGGAGGAACAGGAGGAGCACCAGAAATGTCAGCAGCCCAGGACACCCAGCCCCTTGGTCTTGGAGGGG ACCATCGAACAGAGCTCGCCTCCCCTGAGCCCTACCACCAAACTCATCGACAGGACCGAGTCCCTAAACCGCTCCATAGAGAAGAGTAAC AGTGTGAAGAAATCCCAGCCAGACTTGCCCATCTCCAAGATTGATCAGTGGCTGGAACAATACACCCAGGCCATCGAGACCGCTGGCCGG ACCCCCAAGCTAGCCCGCCAGGCCTCCATAGAGCTGCCCAGCATGGCTGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAG GCTCAGTCTGCGGCCAAGACTCCGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAAGAAAAGCCTCTGGGAGCAGAAGGGAGGCTCC AAGACCTCATCAACAATTAAGAGCACCCCATCTGGGAAGAGGTATAAGTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTG GAAGGGGGCCCGGCTCCCTAGGCGTCCCATCTCGCTTCCTGGGTCTGCAGGTCCAGCCGGCTGGCACCCTCCATGTACCCAGGGGAGATT CCAGCCAGACACCCGCCCCCCGGCCCTGGCTAAGAAGTTGCTTCCTGTTGCCAGCATGACCTACCCTCGCCTCTTTGATGCCATCCGCTG CCACCTCCTTTTGCTCCTGGACCCTTTAGCCTCTCTGCCCTTCCACTCTCTGACCACCGCCCCCGCCCTCCCCACCCAGCTCCGCTTCTT GTTACTTGGGGGAGGAAAGAAACTCCTGATCATTGGCCAAAGGGACTTACCCCTGGAGAGGCCAAGTGCCTTCTAGGAAGTTAGGAGGTT GAGGCACAGCCTGTGCAGAGAGGGTGGGTCACCCCCCCAGATCCAAGGAGAAACTGCAGGTCAAGGGCTGATAACGGCCATGCAGGATGC |
Top |
FusionGenePPI for KCNQ1_LSP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KCNQ1 | TRAF6, AKAP9, PRKAR2A, PPP1CA, PRKACA, KCNE1, KCNE2, KCNQ2, HSPA4, NEDD4, USP2, AP2M1, NEDD4L, ATP4A, EGFR, BACE1 | LSP1 | MAP2K1, ERC2, PRKCB, KSR1, FMNL1, BAG3, CD209, MAPKAPK2, GREB1, IL24, KLK6, LYPD3, SCGB2A2, SNAI1, THRSP, U2AF2, BTRC, SCIN, ZMYM6, GSN, FBXW11, TMOD2, CAPN2, ACTBL2, LIMA1, MYO1B, ACTB, PLEKHG3, TMOD1, MYO1D |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 588_616 | 128 | 677 | AKAP9 |
Hgene | KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 588_616 | -92 | 550 | AKAP9 |
Hgene | KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000155840 | + | 1 | 16 | 535_572 | 128 | 677 | KCNE1 C-terminus |
Hgene | KCNQ1 | chr11:2466714 | chr11:1901317 | ENST00000335475 | + | 1 | 16 | 535_572 | -92 | 550 | KCNE1 C-terminus |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KCNQ1_LSP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | KCNQ1 | P51787 | DB00808 | Indapamide | Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000305} | small molecule | approved |
Hgene | KCNQ1 | P51787 | DB11633 | Isavuconazole | Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000305} | small molecule | approved|investigational |
Hgene | KCNQ1 | P51787 | DB01244 | Bepridil | Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000305} | small molecule | approved|withdrawn |
Top |
RelatedDiseases for KCNQ1_LSP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KCNQ1 | C0035828 | Romano-Ward Syndrome | 36 | CTD_human;ORPHANET;UNIPROT |
Hgene | KCNQ1 | C0022387 | Jervell-Lange Nielsen Syndrome | 9 | CTD_human;ORPHANET;UNIPROT |
Hgene | KCNQ1 | C0023976 | Long QT Syndrome | 7 | CTD_human |
Hgene | KCNQ1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human |
Hgene | KCNQ1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | KCNQ1 | C0018781 | Noise-induced hearing loss | 1 | CTD_human |
Hgene | KCNQ1 | C0021841 | Intestinal Neoplasms | 1 | CTD_human |
Hgene | KCNQ1 | C1837014 | Atrial Fibrillation, Familial, 3 | 1 | CTD_human;UNIPROT |
Hgene | KCNQ1 | C1865019 | SHORT QT SYNDROME 2 (disorder) | 1 | CTD_human;UNIPROT |
Tgene | LSP1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | LSP1 | C0006663 | Calcinosis | 1 | CTD_human |
Tgene | LSP1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Tgene | LSP1 | C0018824 | Heart valve disease | 1 | CTD_human |