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Fusion gene ID: 18320 |
FusionGeneSummary for KCNN3_YEATS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNN3_YEATS4 | Fusion gene ID: 18320 | Hgene | Tgene | Gene symbol | KCNN3 | YEATS4 | Gene ID | 3782 | 8089 |
| Gene name | potassium calcium-activated channel subfamily N member 3 | YEATS domain containing 4 | |
| Synonyms | KCa2.3|SK3|SKCA3|hSK3 | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | |
| Cytomap | 1q21.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UGI6 | O95619 | |
| Ensembl transtripts involved in fusion gene | ENST00000271915, ENST00000361147, ENST00000358505, ENST00000515643, | ENST00000247843, ENST00000548020, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 8 X 3 X 4=96 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCNN3 [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| Tgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A2QS-01A | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000271915 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000271915 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000361147 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000361147 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| Frame-shit | ENST00000358505 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| Frame-shit | ENST00000358505 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| intron-3CDS | ENST00000515643 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| intron-3CDS | ENST00000515643 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
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FusionProtFeatures for KCNN3_YEATS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNN3 | YEATS4 |
| Forms a voltage-independent potassium channel activatedby intracellular calcium. Activation is followed by membranehyperpolarization. Thought to regulate neuronal excitability bycontributing to the slow component of synapticafterhyperpolarization. The channel is blocked by apamin. | Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 30_99 | 217 | 419 | Compositional bias | Note=Gln-rich |
| Hgene | KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 42_64 | 217 | 419 | Compositional bias | Note=Pro-rich |
| Hgene | KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 30_99 | 225 | 427 | Compositional bias | Note=Gln-rich |
| Hgene | KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 42_64 | 225 | 427 | Compositional bias | Note=Pro-rich |
| Tgene | >YEATS4 | chr1:154705479 | chr12:69756568 | ENST00000247843 | + | 0 | 7 | 178_226 | 17 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >YEATS4 | chr1:154705479 | chr12:69756568 | ENST00000247843 | + | 0 | 7 | 22_126 | 17 | 228 | Domain | YEATS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 688_692 | 217 | 419 | Compositional bias | Note=Poly-Gln |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 732_735 | 217 | 419 | Compositional bias | Note=Poly-Ser |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 688_692 | 225 | 427 | Compositional bias | Note=Poly-Gln |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 732_735 | 225 | 427 | Compositional bias | Note=Poly-Ser |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 499_519 | 217 | 419 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 499_519 | 225 | 427 | Intramembrane | Pore-forming%3B Name%3DSegment H5 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 566_642 | 217 | 419 | Region | Calmodulin-binding |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 566_642 | 225 | 427 | Region | Calmodulin-binding |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 293_313 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 320_340 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 371_391 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 410_430 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 459_479 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000358505 | - | 4 | 8 | 528_548 | 217 | 419 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 293_313 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 320_340 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 371_391 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 410_430 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 459_479 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | >KCNN3 | chr1:154705479 | chr12:69756568 | ENST00000361147 | - | 4 | 8 | 528_548 | 225 | 427 | Transmembrane | Helical%3B Name%3DSegment S6 |
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FusionGeneSequence for KCNN3_YEATS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_741aa MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQ LQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKY SGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKL GHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTY ERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFV MKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVY GNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHL LKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRET >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_687aa MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQ LQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKY SGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKL GHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTY ERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFV MKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVY GNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETE >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_436aa MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAY VKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQ >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_382aa MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYH LLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_2223nt ATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTTGGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAG CAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCCAGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAG CCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAA CTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCCCACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTC CACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCACTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGC GGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCGGGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTAT AGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCGGAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTT TTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGAGGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACC CACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTG GGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATA GAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTT TTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTAC GAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTG GCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGA GTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTC ATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTC TGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTAT GGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTAC GGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAG GATATGTCAGCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAA ATTACTGAAACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTG CTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCA ACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTG AAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACT >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_2061nt ATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTTGGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAG CAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCCAGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAG CCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAA CTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCCCACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTC CACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCACTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGC GGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCGGGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTAT AGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCGGAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTT TTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGAGGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACC CACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTG GGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATA GAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTT TTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTAC GAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTG GCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGA GTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTC ATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTC TGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTAT GGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTAC GGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAG GTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAA ATGATATTTCAAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAA TTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTA >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_1308nt ATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATC GCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTAC ATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACA CCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCAC AGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATG ACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCAT GACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCC CACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGG TATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCAGCATAT GTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAAACAGGA TGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTGCTAAAGCTGTTTCAA TCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAA CAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAA TTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAA >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_1146nt ATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATC GCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTAC ATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACA CCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCAC AGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATG ACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCAT GACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCC CACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGG TATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCAT TTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGAC CCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAA GTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_3019nt TTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAGAGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCT CCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCATTCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAA GCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGGAGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGC TTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTT GGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCC AGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCA GCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCC CACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCA CTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCG GGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCG GAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGA GGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTT CCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGA CTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTT TTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTT CGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCAT CCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACAT CATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCG CAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGT GTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCT GGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCT CCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGG GCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCAGCATATGTGAAGAAAATCCAGTTTAAATTACATGA AAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAAACAGGATGGGGTGAATTCGAAATAATCATCAAAAT ATTTTTCATTGACCCTAATGAAAGACCTGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAA GACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAAC ATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTT TGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGA CCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTA CTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCA ATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAG TTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAAT TTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTG >In-frame_KCNN3_ENST00000271915_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_2692nt TTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAGAGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCT CCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCATTCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAA GCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGGAGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGC TTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTT GGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCC AGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCA GCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCC CACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCA CTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCG GGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCG GAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGA GGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTT CCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGA CTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTT TTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTT CGTGATCGACAATGGCGCGGATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCAT CCACCCCATTCCTGGCGAGTACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACAT CATCCTGTCTATCCCCATGTTCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCG CAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGT GTTCAGCATCTCTCTGTGGATCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCT GGGTGCCATGTGGCTCATCTCCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCT CCTCACTGGCATCATGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGG GCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCAGACACCAA TGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAATTATTGAC AACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGC TAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAG AAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTC ACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGA ATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATT >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000247843_chr12_69756568_+_1919nt CAGGAAAGTCAGCTTAAAGGACACTCCTTGCAGGGACTGAGCTGGCACCTACTCCTTAGAGCTTGCTGATACCAGGCCTGCCACGCGACA TCTGCAAGGACAGTTGTTTGGTGTTTTGCTTCAGGTTATAGATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCC TTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGG ATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGT ACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGT TCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACA AGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGA TCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCT CCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTG TTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAG TATATGTGAAACCATATAGAAATGAGGATATGTCAGCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAA GAGTTGTTACTAAACCTCCATATGAAATTACTGAAACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATG AAAGACCTGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGACAGTGGTTTCAGAGTTCT ATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACATTAGGAGCCTATAAGCATG AAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGAGATTGCAGAGCTTAAGG AGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCAAGCAAAAGACATATAAA CAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTGCAAATGCTGTGATGTTT CTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATCTTTAATGGAAAATATGT GTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTTTTAAAAATGTTTATTGT AGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTTGTACTTCTTTAGTGGCT AGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTGTATATGATGTGTCCAGTAAG >In-frame_KCNN3_ENST00000361147_chr1_154705479_-_YEATS4_ENST00000548020_chr12_69756568_+_1592nt CAGGAAAGTCAGCTTAAAGGACACTCCTTGCAGGGACTGAGCTGGCACCTACTCCTTAGAGCTTGCTGATACCAGGCCTGCCACGCGACA TCTGCAAGGACAGTTGTTTGGTGTTTTGCTTCAGGTTATAGATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCC TTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGCTCTTCGTGATCGACAATGGCGCGG ATGACTGGCGGATAGCCATGACCTACGAGCGCATCCTGTACATCAGCCTGGAGATGCTGGTGTGCGCCATCCACCCCATTCCTGGCGAGT ACAAGTTCTTCTGGACGGCACGCCTGGCCTTCTCCTACACACCCTCCCGGGCGGAGGCCGATGTGGACATCATCCTGTCTATCCCCATGT TCCTGCGCCTGTACCTGATCGCCCGAGTCATGCTGCTGCACAGCAAGCTCTTCACCGATGCCTCGTCCCGCAGCATCGGGGCCCTCAACA AGATCAACTTCAACACCCGCTTTGTCATGAAGACGCTCATGACCATCTGCCCTGGCACTGTGCTGCTCGTGTTCAGCATCTCTCTGTGGA TCATTGCTGCCTGGACCGTCCGTGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCATGTGGCTCATCT CCATCACATTCCTTTCCATTGGTTATGGGGACATGGTGCCCCACACATACTGTGGGAAAGGTGTCTGTCTCCTCACTGGCATCATGGGTG TTACTATCGTTAAACCAATAGTTTACGGTAATGTTGCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAG TATATGTGAAACCATATAGAAATGAGGTAACCCTGTATCATTTGCTAAAGCTGTTTCAATCAGACACCAATGCAATGCTGGGGAAAAAGA CAGTGGTTTCAGAGTTCTATGATGAAATGATATTTCAAGACCCAACAGCAATGATGCAACAATTATTGACAACATCTCGTCAGCTAACAT TAGGAGCCTATAAGCATGAAACAGAATTTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTG AGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACC AAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACT GCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAAT CTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTT |
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FusionGenePPI for KCNN3_YEATS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KCNN3 | CALM1, APP, CAV1, DNM2, RAB5A | YEATS4 | TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | YEATS4 | chr1:154705479 | chr12:69756568 | ENST00000247843 | + | 0 | 7 | 163_227 | 17 | 228 | MLLT10 |
| Tgene | YEATS4 | chr1:154705479 | chr12:69756568 | ENST00000247843 | + | 0 | 7 | 168_227 | 17 | 228 | TACC1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCNN3_YEATS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KCNN3 | Q9UGI6 | DB01110 | Miconazole | Small conductance calcium-activated potassium channel protein 3 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for KCNN3_YEATS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KCNN3 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | KCNN3 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | KCNN3 | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| Tgene | YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |
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