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Fusion gene ID: 1831 |
FusionGeneSummary for ANKRD28_EYS |
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Fusion gene information | Fusion gene name: ANKRD28_EYS | Fusion gene ID: 1831 | Hgene | Tgene | Gene symbol | ANKRD28 | EYS | Gene ID | 23243 | 346007 |
Gene name | ankyrin repeat domain 28 | eyes shut homolog (Drosophila) | |
Synonyms | PITK|PPP1R65 | C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1 | |
Cytomap | 3p25.1 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory | protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O15084 | Q5T1H1 | |
Ensembl transtripts involved in fusion gene | ENST00000383777, ENST00000399451, ENST00000497037, | ENST00000503581, ENST00000370621, ENST00000370616, ENST00000393380, ENST00000342421, ENST00000370618, ENST00000486069, | |
Fusion gene scores | * DoF score | 11 X 10 X 10=1100 | 26 X 15 X 12=4680 |
# samples | 12 | 27 | |
** MAII score | log2(12/1100*10)=-3.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ANKRD28 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A06Q-01A | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000383777 | ENST00000503581 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000383777 | ENST00000370621 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000383777 | ENST00000370616 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000383777 | ENST00000393380 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000383777 | ENST00000342421 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000383777 | ENST00000370618 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000383777 | ENST00000486069 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000399451 | ENST00000503581 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000399451 | ENST00000370621 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000399451 | ENST00000370616 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000399451 | ENST00000393380 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000399451 | ENST00000342421 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000399451 | ENST00000370618 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000399451 | ENST00000486069 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000497037 | ENST00000503581 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000497037 | ENST00000370621 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000497037 | ENST00000370616 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000497037 | ENST00000393380 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000497037 | ENST00000342421 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000497037 | ENST00000370618 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000497037 | ENST00000486069 | ANKRD28 | chr3 | 15855747 | - | EYS | chr6 | 66205886 | - |
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FusionProtFeatures for ANKRD28_EYS |
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Hgene | Tgene |
ANKRD28 | EYS |
Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. Involved in the PP6-mediated dephosphorylation ofNFKBIE opposing its degradation in response to TNF-alpha.Selectively inhibits the phosphatase activity of PPP1C. TargetsPPP1C to modulate HNRPK phosphorylation.{ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANKRD28_EYS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANKRD28_EYS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANKRD28 | TBK1, USP21, USP49, PLK1, PPP6C, SIRT7, AP2M1, BRCA1, ZNF512B, TGM2, CSNK2B, AGPAT2, FBXO6, USP10, ACACB, AKAP8L, ANKRD44, APC, ARHGEF2, CEP192, DNAJB1, EPS8, FAM175B, FAM193A, FBF1, HECTD1, CEP162, KRI1, MAGED1, MTMR3, NEK4, NFATC4, NOTCH2, PLEKHG1, PPP1R9A, PPP1R9B, PPP6R1, PPP6R2, PPP6R3, RAD21, RASSF8, RCN2, SDCCAG3, SEC16A, SHKBP1, SMC1A, SMC3, SNX18, TBKBP1, TRIM41, UBR5, MOB1A, MOB1B, CTTNBP2NL, FLNC, LEO1, HOXC4, NECAP2, SDCBP, FOXD4L6, DCLRE1C, PLK2, NTRK1, CEP128, CEP44, CNTRL, ODF2, RPGRIP1L, CEP19, LCA5, XRCC6, FOXK1, FOXK2, ZNRF2, ZNF574, TRMT2A, ZNF785, CIRH1A, CAMK4, CDKL1, MRPS7, DFNB31, TRIM25 | EYS | EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANKRD28_EYS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD28_EYS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EYS | C1864446 | Retinitis Pigmentosa 25 | 2 | CTD_human;UNIPROT |
Tgene | EYS | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;ORPHANET |