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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1831

FusionGeneSummary for ANKRD28_EYS

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD28_EYS
Fusion gene ID: 1831
HgeneTgene
Gene symbol

ANKRD28

EYS

Gene ID

23243

346007

Gene nameankyrin repeat domain 28eyes shut homolog (Drosophila)
SynonymsPITK|PPP1R65C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
Cytomap

3p25.1

6q12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
Modification date2018051920180519
UniProtAcc

O15084

Q5T1H1

Ensembl transtripts involved in fusion geneENST00000383777, ENST00000399451, 
ENST00000497037, 
ENST00000503581, 
ENST00000370621, ENST00000370616, 
ENST00000393380, ENST00000342421, 
ENST00000370618, ENST00000486069, 
Fusion gene scores* DoF score11 X 10 X 10=110026 X 15 X 12=4680
# samples 1227
** MAII scorelog2(12/1100*10)=-3.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD28 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A06Q-01AANKRD28chr3

15855747

-EYSchr6

66205886

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000383777ENST00000503581ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000383777ENST00000370621ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000383777ENST00000370616ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000383777ENST00000393380ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000383777ENST00000342421ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000383777ENST00000370618ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000383777ENST00000486069ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000399451ENST00000503581ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000399451ENST00000370621ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000399451ENST00000370616ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000399451ENST00000393380ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000399451ENST00000342421ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000399451ENST00000370618ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000399451ENST00000486069ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000497037ENST00000503581ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000497037ENST00000370621ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000497037ENST00000370616ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000497037ENST00000393380ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000497037ENST00000342421ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-5UTRENST00000497037ENST00000370618ANKRD28chr3

15855747

-EYSchr6

66205886

-
intron-intronENST00000497037ENST00000486069ANKRD28chr3

15855747

-EYSchr6

66205886

-

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FusionProtFeatures for ANKRD28_EYS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD28

O15084

EYS

Q5T1H1

Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. Involved in the PP6-mediated dephosphorylation ofNFKBIE opposing its degradation in response to TNF-alpha.Selectively inhibits the phosphatase activity of PPP1C. TargetsPPP1C to modulate HNRPK phosphorylation.{ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD28_EYS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD28_EYS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD28TBK1, USP21, USP49, PLK1, PPP6C, SIRT7, AP2M1, BRCA1, ZNF512B, TGM2, CSNK2B, AGPAT2, FBXO6, USP10, ACACB, AKAP8L, ANKRD44, APC, ARHGEF2, CEP192, DNAJB1, EPS8, FAM175B, FAM193A, FBF1, HECTD1, CEP162, KRI1, MAGED1, MTMR3, NEK4, NFATC4, NOTCH2, PLEKHG1, PPP1R9A, PPP1R9B, PPP6R1, PPP6R2, PPP6R3, RAD21, RASSF8, RCN2, SDCCAG3, SEC16A, SHKBP1, SMC1A, SMC3, SNX18, TBKBP1, TRIM41, UBR5, MOB1A, MOB1B, CTTNBP2NL, FLNC, LEO1, HOXC4, NECAP2, SDCBP, FOXD4L6, DCLRE1C, PLK2, NTRK1, CEP128, CEP44, CNTRL, ODF2, RPGRIP1L, CEP19, LCA5, XRCC6, FOXK1, FOXK2, ZNRF2, ZNF574, TRMT2A, ZNF785, CIRH1A, CAMK4, CDKL1, MRPS7, DFNB31, TRIM25EYSEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD28_EYS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD28_EYS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEYSC1864446Retinitis Pigmentosa 252CTD_human;UNIPROT
TgeneEYSC0035334Retinitis Pigmentosa1CTD_human;ORPHANET