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Fusion gene ID: 183 |
FusionGeneSummary for ABCE1_DDX39B |
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Fusion gene information | Fusion gene name: ABCE1_DDX39B | Fusion gene ID: 183 | Hgene | Tgene | Gene symbol | ABCE1 | DDX39B | Gene ID | 6059 | 7919 |
Gene name | ATP binding cassette subfamily E member 1 | DExD-box helicase 39B | |
Synonyms | ABC38|OABP|RLI|RLI1|RNASEL1|RNASELI|RNS4I | BAT1|D6S81E|UAP56 | |
Cytomap | 4q31.21 | 6p21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-binding cassette sub-family E member 12'-5'-oligoadenylate-binding proteinATP-binding cassette, sub-family E (OABP), member 1RNase L inhibitor 1huHP68ribonuclease 4 inhibitorribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor | spliceosome RNA helicase DDX39B56 kDa U2AF65-associated proteinATP-dependent RNA helicase p47DEAD (Asp-Glu-Ala-Asp) box polypeptide 39BDEAD-box helicase 39BHLA-B-associated transcript 1 proteinnuclear RNA helicase (DEAD family)spliceosome RNA helic | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P61221 | Q13838 | |
Ensembl transtripts involved in fusion gene | ENST00000296577, ENST00000502803, | ENST00000376177, ENST00000396172, ENST00000417556, ENST00000458640, ENST00000462421, ENST00000415382, ENST00000453105, ENST00000449074, ENST00000552820, ENST00000463430, ENST00000438578, ENST00000415689, ENST00000456476, ENST00000412106, ENST00000547039, ENST00000550435, ENST00000453488, ENST00000453138, ENST00000552288, ENST00000441425, ENST00000456666, ENST00000546633, ENST00000483957, ENST00000430703, ENST00000416863, ENST00000413678, ENST00000414440, ENST00000547489, ENST00000551031, ENST00000468089, ENST00000400293, ENST00000400296, ENST00000400295, ENST00000383508, ENST00000548340, ENST00000548331, ENST00000495391, ENST00000446341, ENST00000548614, ENST00000448296, ENST00000412330, ENST00000445218, ENST00000546637, ENST00000489325, ENST00000450987, ENST00000431360, ENST00000430784, ENST00000550217, ENST00000470514, ENST00000549374, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 1=16 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ABCE1 [Title/Abstract] AND DDX39B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABCE1 | GO:0060702 | negative regulation of endoribonuclease activity | 7539425 |
Tgene | DDX39B | GO:0000245 | spliceosomal complex assembly | 18593880 |
Tgene | DDX39B | GO:0006406 | mRNA export from nucleus | 17190602 |
Tgene | DDX39B | GO:0008380 | RNA splicing | 18593880 |
Tgene | DDX39B | GO:0010501 | RNA secondary structure unwinding | 18593880 |
Tgene | DDX39B | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AB062293 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000296577 | ENST00000376177 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000396172 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000417556 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000458640 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000462421 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000415382 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000453105 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000449074 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000552820 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000463430 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000438578 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000415689 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000456476 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000412106 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000547039 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000550435 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000453488 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000453138 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000552288 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000441425 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000456666 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000546633 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000483957 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000430703 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000416863 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000413678 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000414440 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000547489 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000551031 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000468089 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000400293 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000400296 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000400295 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000383508 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000548340 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000548331 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000495391 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000446341 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000548614 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000448296 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000412330 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000445218 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000546637 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000489325 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-3UTR | ENST00000296577 | ENST00000450987 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-3UTR | ENST00000296577 | ENST00000431360 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-3UTR | ENST00000296577 | ENST00000430784 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-3UTR | ENST00000296577 | ENST00000550217 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-5UTR | ENST00000296577 | ENST00000470514 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
3UTR-intron | ENST00000296577 | ENST00000549374 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000376177 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000396172 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000417556 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000458640 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000462421 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000415382 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000453105 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000449074 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000552820 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000463430 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000438578 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000415689 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000456476 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000412106 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000547039 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000550435 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000453488 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000453138 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000552288 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000441425 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000456666 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000546633 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000483957 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000430703 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000416863 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000413678 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000414440 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000547489 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000551031 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000468089 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000400293 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000400296 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000400295 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000383508 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000548340 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000548331 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000495391 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000446341 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000548614 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000448296 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000412330 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000445218 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000546637 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000489325 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-3UTR | ENST00000502803 | ENST00000450987 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-3UTR | ENST00000502803 | ENST00000431360 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-3UTR | ENST00000502803 | ENST00000430784 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-3UTR | ENST00000502803 | ENST00000550217 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-5UTR | ENST00000502803 | ENST00000470514 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
intron-intron | ENST00000502803 | ENST00000549374 | ABCE1 | chr4 | 146049667 | + | DDX39B | chr6 | 2828923 | - |
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FusionProtFeatures for ABCE1_DDX39B |
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Hgene | Tgene |
ABCE1 | DDX39B |
Antagonizes the binding of 2-5A (5'-phosphorylated2',5'-linked oligoadenylates) by RNase L through directinteraction with RNase L and therefore inhibits itsendoribonuclease activity. May play a central role in theregulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as achaperone for post-translational events during HIV-1 capsidassembly. {ECO:0000269|PubMed:11585831,ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ABCE1_DDX39B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ABCE1_DDX39B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ABCE1_DDX39B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | DDX39B | Q13838 | DB02325 | Isopropyl Alcohol | Spliceosome RNA helicase DDX39B | small molecule | approved|investigational |
Tgene | DDX39B | Q13838 | DB11638 | Artenimol | Spliceosome RNA helicase DDX39B | small molecule | approved|investigational |
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RelatedDiseases for ABCE1_DDX39B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCE1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |