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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 183

FusionGeneSummary for ABCE1_DDX39B

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCE1_DDX39B
Fusion gene ID: 183
HgeneTgene
Gene symbol

ABCE1

DDX39B

Gene ID

6059

7919

Gene nameATP binding cassette subfamily E member 1DExD-box helicase 39B
SynonymsABC38|OABP|RLI|RLI1|RNASEL1|RNASELI|RNS4IBAT1|D6S81E|UAP56
Cytomap

4q31.21

6p21.33

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family E member 12'-5'-oligoadenylate-binding proteinATP-binding cassette, sub-family E (OABP), member 1RNase L inhibitor 1huHP68ribonuclease 4 inhibitorribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitorspliceosome RNA helicase DDX39B56 kDa U2AF65-associated proteinATP-dependent RNA helicase p47DEAD (Asp-Glu-Ala-Asp) box polypeptide 39BDEAD-box helicase 39BHLA-B-associated transcript 1 proteinnuclear RNA helicase (DEAD family)spliceosome RNA helic
Modification date2018052320180522
UniProtAcc

P61221

Q13838

Ensembl transtripts involved in fusion geneENST00000296577, ENST00000502803, 
ENST00000376177, ENST00000396172, 
ENST00000417556, ENST00000458640, 
ENST00000462421, ENST00000415382, 
ENST00000453105, ENST00000449074, 
ENST00000552820, ENST00000463430, 
ENST00000438578, ENST00000415689, 
ENST00000456476, ENST00000412106, 
ENST00000547039, ENST00000550435, 
ENST00000453488, ENST00000453138, 
ENST00000552288, ENST00000441425, 
ENST00000456666, ENST00000546633, 
ENST00000483957, ENST00000430703, 
ENST00000416863, ENST00000413678, 
ENST00000414440, ENST00000547489, 
ENST00000551031, ENST00000468089, 
ENST00000400293, ENST00000400296, 
ENST00000400295, ENST00000383508, 
ENST00000548340, ENST00000548331, 
ENST00000495391, ENST00000446341, 
ENST00000548614, ENST00000448296, 
ENST00000412330, ENST00000445218, 
ENST00000546637, ENST00000489325, 
ENST00000450987, ENST00000431360, 
ENST00000430784, ENST00000550217, 
ENST00000470514, ENST00000549374, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 1=16
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABCE1 [Title/Abstract] AND DDX39B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCE1

GO:0060702

negative regulation of endoribonuclease activity

7539425

TgeneDDX39B

GO:0000245

spliceosomal complex assembly

18593880

TgeneDDX39B

GO:0006406

mRNA export from nucleus

17190602

TgeneDDX39B

GO:0008380

RNA splicing

18593880

TgeneDDX39B

GO:0010501

RNA secondary structure unwinding

18593880

TgeneDDX39B

GO:0046784

viral mRNA export from host cell nucleus

18974867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AB062293ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000296577ENST00000376177ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000396172ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000417556ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000458640ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000462421ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000415382ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000453105ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000449074ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000552820ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000463430ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000438578ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000415689ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000456476ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000412106ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000547039ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000550435ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000453488ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000453138ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000552288ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000441425ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000456666ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000546633ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000483957ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000430703ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000416863ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000413678ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000414440ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000547489ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000551031ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000468089ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000400293ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000400296ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000400295ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000383508ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000548340ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000548331ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000495391ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000446341ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000548614ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000448296ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000412330ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000445218ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000546637ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000489325ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-3UTRENST00000296577ENST00000450987ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-3UTRENST00000296577ENST00000431360ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-3UTRENST00000296577ENST00000430784ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-3UTRENST00000296577ENST00000550217ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-5UTRENST00000296577ENST00000470514ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
3UTR-intronENST00000296577ENST00000549374ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000376177ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000396172ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000417556ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000458640ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000462421ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000415382ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000453105ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000449074ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000552820ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000463430ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000438578ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000415689ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000456476ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000412106ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000547039ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000550435ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000453488ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000453138ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000552288ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000441425ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000456666ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000546633ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000483957ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000430703ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000416863ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000413678ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000414440ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000547489ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000551031ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000468089ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000400293ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000400296ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000400295ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000383508ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000548340ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000548331ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000495391ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000446341ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000548614ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000448296ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000412330ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000445218ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000546637ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000489325ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-3UTRENST00000502803ENST00000450987ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-3UTRENST00000502803ENST00000431360ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-3UTRENST00000502803ENST00000430784ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-3UTRENST00000502803ENST00000550217ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-5UTRENST00000502803ENST00000470514ABCE1chr4

146049667

+DDX39Bchr6

2828923

-
intron-intronENST00000502803ENST00000549374ABCE1chr4

146049667

+DDX39Bchr6

2828923

-

Top

FusionProtFeatures for ABCE1_DDX39B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCE1

P61221

DDX39B

Q13838

Antagonizes the binding of 2-5A (5'-phosphorylated2',5'-linked oligoadenylates) by RNase L through directinteraction with RNase L and therefore inhibits itsendoribonuclease activity. May play a central role in theregulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as achaperone for post-translational events during HIV-1 capsidassembly. {ECO:0000269|PubMed:11585831,ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCE1_DDX39B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ABCE1_DDX39B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ABCE1_DDX39B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDDX39BQ13838DB02325Isopropyl AlcoholSpliceosome RNA helicase DDX39Bsmall moleculeapproved|investigational
TgeneDDX39BQ13838DB11638ArtenimolSpliceosome RNA helicase DDX39Bsmall moleculeapproved|investigational

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RelatedDiseases for ABCE1_DDX39B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCE1C0009404Colorectal Neoplasms1CTD_human