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Fusion gene ID: 18274 |
FusionGeneSummary for KCNJ15_ZFPM1 |
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Fusion gene information | Fusion gene name: KCNJ15_ZFPM1 | Fusion gene ID: 18274 | Hgene | Tgene | Gene symbol | KCNJ15 | ZFPM1 | Gene ID | 3772 | 161882 |
Gene name | potassium voltage-gated channel subfamily J member 15 | zinc finger protein, FOG family member 1 | |
Synonyms | IRKK|KIR1.3|KIR4.2 | FOG|FOG1|ZC2HC11A|ZNF408|ZNF89A | |
Cytomap | 21q22.13-q22.2 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-sensitive inward rectifier potassium channel 15inward rectifier K(+) channel Kir1.3inward rectifier K(+) channel Kir4.2inward rectifier K+ channel KIR4.2potassium channel, inwardly rectifying subfamily J member 15potassium inwardly-rectifying cha | zinc finger protein ZFPM1FOG-1friend of GATA 1friend of GATA protein 1zinc finger protein 89Azinc finger protein, multitype 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99712 | Q8IX07 | |
Ensembl transtripts involved in fusion gene | ENST00000328656, ENST00000398938, ENST00000398932, ENST00000398930, ENST00000398934, | ENST00000319555, ENST00000569086, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KCNJ15 [Title/Abstract] AND ZFPM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ZFPM1 | GO:0010724 | regulation of definitive erythrocyte differentiation | 15920471 |
Tgene | ZFPM1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 21646796 |
Tgene | ZFPM1 | GO:0045403 | negative regulation of interleukin-4 biosynthetic process | 21646796 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AJ311492 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000328656 | ENST00000319555 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000328656 | ENST00000569086 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398938 | ENST00000319555 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398938 | ENST00000569086 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398932 | ENST00000319555 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398932 | ENST00000569086 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398930 | ENST00000319555 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398930 | ENST00000569086 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398934 | ENST00000319555 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
intron-intron | ENST00000398934 | ENST00000569086 | KCNJ15 | chr21 | 39618910 | - | ZFPM1 | chr16 | 88587240 | - |
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FusionProtFeatures for KCNJ15_ZFPM1 |
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Hgene | Tgene |
KCNJ15 | ZFPM1 |
Inward rectifier potassium channels are characterized bya greater tendency to allow potassium to flow into the cell ratherthan out of it. Their voltage dependence is regulated by theconcentration of extracellular potassium; as external potassium israised, the voltage range of the channel opening shifts to morepositive voltages. The inward rectification is mainly due to theblockage of outward current by internal magnesium. | Transcription regulator that plays an essential role inerythroid and megakaryocytic cell differentiation. Essentialcofactor that acts via the formation of a heterodimer withtranscription factors of the GATA family GATA1, GATA2 and GATA3.Such heterodimer can both activate or repress transcriptionalactivity, depending on the cell and promoter context. Theheterodimer formed with GATA proteins is essential to activateexpression of genes such as NFE2, ITGA2B, alpha- and beta-globin,while it represses expression of KLF1. May be involved inregulation of some genes in gonads. May also be involved incardiac development, in a non-redundant way with ZFPM2/FOG2 (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KCNJ15_ZFPM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KCNJ15_ZFPM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCNJ15_ZFPM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KCNJ15_ZFPM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KCNJ15 | C3495559 | Juvenile arthritis | 1 | CTD_human |