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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18268

FusionGeneSummary for KCNIP4_GSN

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNIP4_GSN
Fusion gene ID: 18268
HgeneTgene
Gene symbol

KCNIP4

GSN

Gene ID

80333

2934

Gene namepotassium voltage-gated channel interacting protein 4gelsolin
SynonymsCALP|KCHIP4ADF|AGEL
Cytomap

4p15.31-p15.2

9q33.2

Type of geneprotein-codingprotein-coding
DescriptionKv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like proteingelsolinactin-depolymerizing factorbrevin
Modification date2018052320180522
UniProtAcc

Q6PIL6

P06396

Ensembl transtripts involved in fusion geneENST00000382148, ENST00000447367, 
ENST00000382150, ENST00000382152, 
ENST00000509207, ENST00000382149, 
ENST00000359001, 		ENST00000373823, 
ENST00000373808, ENST00000436847, 
ENST00000449733, ENST00000412819, 
ENST00000394353, ENST00000341272, 
ENST00000545652, ENST00000373818, 
ENST00000485767, ENST00000373807, 
ENST00000373806, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 8 X 1=40
# samples 59
** MAII scorelog2(5/50*10)=0log2(9/40*10)=1.16992500144231
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCNIP4 [Title/Abstract] AND GSN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSN

GO:0030041

actin filament polymerization

3020431

TgeneGSN

GO:0051014

actin filament severing

3020431


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ477488KCNIP4chr4

21463066

+GSNchr9

124095120

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000382148ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382148ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000447367ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382150ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382152ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000509207ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000382149ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000373823KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000373808KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000436847KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000449733KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000412819KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000394353KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000341272KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000545652KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000373818KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000485767KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000373807KCNIP4chr4

21463066

+GSNchr9

124095120

-
intron-intronENST00000359001ENST00000373806KCNIP4chr4

21463066

+GSNchr9

124095120

-

Top

FusionProtFeatures for KCNIP4_GSN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNIP4

Q6PIL6

GSN

P06396


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for KCNIP4_GSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCNIP4_GSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KCNIP4_GSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSNP06396DB01593ZincGelsolinsmall moleculeapproved|investigational

Top

RelatedDiseases for KCNIP4_GSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGSNC0025500Mesothelioma1CTD_human
TgeneGSNC0029456Osteoporosis1CTD_human
TgeneGSNC0030524Paratuberculosis1CTD_human
TgeneGSNC0036341Schizophrenia1PSYGENET
TgeneGSNC0043094Weight Gain1CTD_human
TgeneGSNC0948089Acute Coronary Syndrome1CTD_human
TgeneGSNC1622345Meretoja syndrome1CTD_human;ORPHANET;UNIPROT
TgeneGSNC4277682Chemical and Drug Induced Liver Injury1CTD_human