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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18267

FusionGeneSummary for KCNIP4_GRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNIP4_GRK4
Fusion gene ID: 18267
HgeneTgene
Gene symbol

KCNIP4

GRK4

Gene ID

80333

2868

Gene namepotassium voltage-gated channel interacting protein 4G protein-coupled receptor kinase 4
SynonymsCALP|KCHIP4GPRK2L|GPRK4|GRK4a|IT11
Cytomap

4p15.31-p15.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionKv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like proteinG protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like
Modification date2018052320180519
UniProtAcc

Q6PIL6

P32298

Ensembl transtripts involved in fusion geneENST00000382148, ENST00000447367, 
ENST00000382150, ENST00000382152, 
ENST00000509207, ENST00000382149, 
ENST00000359001, 		ENST00000398051, 
ENST00000398052, ENST00000504933, 
ENST00000345167, ENST00000503518, 
ENST00000442472, ENST00000509545, 
Fusion gene scores* DoF score5 X 5 X 2=504 X 7 X 6=168
# samples 57
** MAII scorelog2(5/50*10)=0log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNIP4 [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRK4

GO:0031623

receptor internalization

20074556


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-4W-AA9S-01AKCNIP4chr4

21546013

-GRK4chr4

3005958

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382148ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382148ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382148ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382148ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382148ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382148ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382148ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000447367ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000447367ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000447367ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000447367ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000447367ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000447367ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000447367ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382150ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382150ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382150ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382150ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382150ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382150ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382150ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382152ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382152ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382152ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382152ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382152ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382152ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382152ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-3CDSENST00000509207ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-3CDSENST00000509207ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-3CDSENST00000509207ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-3CDSENST00000509207ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-intronENST00000509207ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-intronENST00000509207ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
5UTR-intronENST00000509207ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382149ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382149ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382149ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000382149ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382149ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382149ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000382149ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000359001ENST00000398051KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000359001ENST00000398052KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000359001ENST00000504933KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-3CDSENST00000359001ENST00000345167KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000359001ENST00000503518KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000359001ENST00000442472KCNIP4chr4

21546013

-GRK4chr4

3005958

+
intron-intronENST00000359001ENST00000509545KCNIP4chr4

21546013

-GRK4chr4

3005958

+

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FusionProtFeatures for KCNIP4_GRK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNIP4

Q6PIL6

GRK4

P32298


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KCNIP4_GRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KCNIP4_GRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KCNIP4KCNIP2, PSEN2, PSEN1, APP, KCNIP1, SCGB1D1, MTX1, LACRT, ZG16B, PRR4, HLA-DRA, KLK4, TFPI, ECE2GRK4CALM1, FSHR, IKBKG, NEDD4, HSP90AA1, ADRB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KCNIP4_GRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KCNIP4_GRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource